Results of the biopsies from 55 diabetes patients with damage of capillary system on the skin were classified by Larsson’s scale. The state was mainly 2nd grade (41.8%), 1st grade and 3rd grade 29.1%. No case of 4th grade damage. The capillary damage was strictly assosciated to diabetes retinian capillary damage. The damage of skin capillary developed earlier considerably than that of the retine. The damage of capillary system on skin can be considered golden criterion for diagnosis of early damage of the capillary vessel in diabetes.
Skin ; Diabetes Mellitus ; Pathology

55 diabetes patients has negative urine protein 24 hours in 2 consecutive examinations. Among them, 22 had urine aminoalbumin  20 microgram/minute (MAU +), which account for 40%. Their 58.3% of patient had type 1 diabetes and 34.9% type 2. Damage of skin microvascular occurred early, it had a close relation with microalbumin secretory level in urine with r=0.55. Damage of microvascular had close relation with the duration of the disease and it is a most subjective standard for assessing the impairment of microvascularity in diabetic patients
Diabetes Mellitus ; Diseases ; Urinary Tract

A case of Nelson syndrome was presented. Male patient of 26 years old suffering from Cushing disease underwent an bilateral epinephrectomy, after that, Nelson syndrome developed and the patient was treated by Cobalt 60, the skin was discolored and head pain was relieved. Nelson syndrome is caused by total epinephrectomy E in Cushing disease’s patient, its clinical manifestation is typically a leader skin, head pain, high blood concentration of ACTH. The treatment of choice for this syndrome is an operation of pyfrophyse through sphenoidal bone or irradiation into hypophysal hole
Nelson Syndrome ; Cushing Syndrome ; Diseases

From the year 1989 to December 1994, 59 patients with Cushing syndrome (12 males, 47 females aged 15-46) were investigated. Clinical symptoms: central obesis, round face, weakness, high blood pressure, cracked skin, mental disorder, acnea, hirsulism. Laboratory examinations: high level of urine 17OHCS, cortisol secretion increasing in 8 and 20 o’clock and loss of secretion. Morphological examinations: X-ray radiography of hypophysal hole, ultrasound of surrenal gland, CT scan of hypophysal hole. Causes: 79.7% is Cushing disease, 11.8% adenoma od surrenal gland, 8.5% surrenal cancer
Cushing Syndrome ; diagnosis ; epidemiology