1.Study on the effects of naturenz towards antioxidative enzymes in the AO/dioxin exposed patients
Pharmaceutical Journal 2005;0(11):24-26
The study was performed on 26 AO/dioxin exposed patients in the war. Product Naturenz was used to prevent and reduce the damage of polluted substances, and to increase detoxifying process, antioxidant, improve health. Results: Antioxidant enzymes were improved after patients used naturenz with the dose of 2g/day in 2 months (GPX enzyme activity improvement accounted for 57.7%, SOD enzyme activity tented to increase to normal value which accounted for 38.5%, peroxidase activity improvement accounted for 61,8%). Especially, in total antioxidant activity, Hemoglobin content and SH-group content improved significantly (increase by 76.9%). Therefore, naturenz have antioxidant effect and improve health for the patients
Enzymes
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Antioxidants
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Dioxins
2.The effect of Morinda citrifolia fruit extracts of Viet Nam on rat hepatic enzyme metabolism
Journal of Medicinal Materials - Hanoi 2005;10(4):128-132
Study on the effects of Morinda citrifolia fruit extracts of Viet Nam on hepatic antioxidant enzymes and P450 enzyme of rat. Results: Morinda citrifolia fruit extracts of Viet Nam had effective antioxidant activities. In CCl4 treated rats received this extract, MDA’s level decreased 10%, SOD activity increased 31% compared with control poisoned rats. Besides, P450 activity os CCl4 treated rats increased by 49.5% when treated by Morinda citrifolia fruit extracts compared with CCl4 treated rats didn’t received extracts, but also decreased by 30.3% compared with control rats. In rats received Morinda citrifolia fruit extracts, P450 activity increased 24.8%
Morinda
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Animal Experimentation
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Metabolism
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Enzymes
3.Investigation of clinical and renal pathological features of acute renal failure in primary nephrotic syndrome
Tuyen Gia Do ; Dung Thi Kim Dinh
Journal of Medical Research 2007;53(5):7-12
Background: Acute renal failure (ARF) is an uncommon but alarming complication of idiopathic nephrotic syndrome. The renal failure could be secondary to causes evident from the history and evaluation, such as severe intravascular volume depletion, acute tubular necrosis but there is no report on this population in Vietnamese adult patients. Objective: To investigate on acute renal failure complicating of nephrotic syndrome. Subjects and method: Patients with idiopathic nephrotic syndrome who were admitted with acute renal failure have been enrolled to investigate the clinical findings, laboratory check up and histology examination. Results:We present 33 patients with idiopathic nephrotic syndrome who were admitted with acute renal failure between June 1997 and June 1998. We describe the clinical and renal pathology features of these patients in whom reversible idiopathic acute renal failure developed during the course of primary nephrotic syndrome (PNS). Improvement in renal function occurred in 80% of patients over a variable period of 10 days to 14 days. The histology findings are interstitial edema, tubular obstruction. Conclusions: Acute renal failure complicating of nephritic syndrome is reversible, the exact pathophysiology of ARF is not understood. Possible causes include edema, tubular obstruction, altered glomerular permeability, and unrecognized hypovolemia.
Acute Kidney Injury/ pathology Nephrotic Syndrome
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Adult
4.Identification of Phenolic Compounds from Vietnamese Artichoke (Cynara scolymus L.) Leaf and Their Antioxidant Activities
Anh Nguyet Thi NGUYEN ; Thanh Tuyen Thi VU ; Hong Tuoi Thi DO ; Thien Hai NGUYEN ; Huan Van LE ; Hong Khuyen Thi PHAM ; Phu Chi Hieu TRUONG ; Dong Phuong PHAM ; Manh Hung TRAN
Natural Product Sciences 2024;30(1):39-51
Artichoke (Cynara scolymus L.) is a perennial plant belonging to the Asteraceae family originating from the Mediterranean region. In Vietnam, there are some varieties of artichoke which are extensively cultivated and propagated in highland areas, however, there have been limited detailed scientific publications on the chemical composition and biological activity of artichoke grown in Vietnam. Therefore, this study provides a detailed description of the extraction, isolation, and structural determination of 20 natural secondary metabolites present in harvested artichoke. The antioxidant activity of the extract and the 9 isolated compounds are tested in 1,1-diphenyl-2-picrylhydrazyl radical scavenging and ex vivo malondialdehyde model. Among the selected compounds, 1-caffeoylquinic acid, 3-caffeoylquinic acid, chlorogenic acid, 4-caffeoylquinic acid, cynarin, 1,5-dicaffeoylquinic acid, 4,5-di-caffeoylquinic acid, cynaroside, and scolymoside exhibited strong radical scavenging activity with IC50 values ranging from 5.7 to 61.6 µM. In the malondialdehyde assay, 1,3-dicaffeoylquinic acid (or cynarin) showed the strongest activity with an IC50 value of 24.7 µM, followed by 1,5-di-caffeoylquinic acid (66.8 µM), and 4,5-di-caffeoylquinic acid (127.3 µM). This outcome contributes to establishing a database on the phytochemical and antioxidant activity of the Vietnamese artichoke.
5.Impact of long COVID-19 on posttraumatic stress disorderas modified by health literacy: an observational study inVietnam
Han Thi VO ; Tien Duc DAO ; Tuyen Van DUONG ; Tan Thanh NGUYEN ; Binh Nhu DO ; Tinh Xuan DO ; Khue Minh PHAM ; Vinh Hai VU ; Linh Van PHAM ; Lien Thi Hong NGUYEN ; Lan Thi Huong LE ; Hoang Cong NGUYEN ; Nga Hoang DANG ; Trung Huu NGUYEN ; Anh The NGUYEN ; Hoan Van NGUYEN ; Phuoc Ba NGUYEN ; Hoai Thi Thanh NGUYEN ; Thu Thi Minh PHAM ; Thuy Thi LE ; Thao Thi Phuong NGUYEN ; Cuong Quoc TRAN ; Kien Trung NGUYEN
Osong Public Health and Research Perspectives 2024;15(1):33-44
Objectives:
The prevalence of posttraumatic stress disorder (PTSD) has increased, particularly among individuals who have recovered from coronavirus disease 2019 (COVID-19) infection. Health literacy is considered a “social vaccine” that helps people respond effectively to the pandemic. We aimed to investigate the association between long COVID-19 and PTSD, and to examine the modifying role of health literacy in this association.
Methods:
A cross-sectional study was conducted at 18 hospitals and health centers in Vietnamfrom December 2021 to October 2022. We recruited 4,463 individuals who had recovered from COVID-19 infection for at least 4 weeks. Participants provided information about their sociodemographics, clinical parameters, health-related behaviors, health literacy (usingthe 12-item short-form health literacy scale), long COVID-19 symptoms and PTSD (Impact Event Scale-Revised score of 33 or higher). Logistic regression models were used to examine associations and interactions.
Results:
Out of the study sample, 55.9% had long COVID-19 symptoms, and 49.6% had PTSD.Individuals with long COVID-19 symptoms had a higher likelihood of PTSD (odds ratio [OR], 1.86; 95% confidence interval [CI], 1.63–2.12; p < 0.001). Higher health literacy was associated with a lower likelihood of PTSD (OR, 0.98; 95% CI, 0.97–0.99; p = 0.001). Compared to those without long COVID-19 symptoms and the lowest health literacy score, those with long COVID-19 symptoms and a 1-point health literacy increment had a 3% lower likelihood of PTSD (OR, 0.97; 95% CI, 0.96–0.99; p = 0.001).
Conclusion
Health literacy was found to be a protective factor against PTSD and modified the negative impact of long COVID-19 symptoms on PTSD.