1.Retroperitoneal Teratoma: A Report of A Case.
Korean Journal of Urology 1962;3(1):77-80
A case of retroperitoneal teratoma, found in a ten month old female infant was reported. Twenty four hours after the direct retroperitoneal air insufflation, a retrograde pyelography was performed using B.B. 16F. cytoscope. These two studies were essential to make preoperative diagnosis. Review of retroperitoneal tumor was also added.
Diagnosis
;
Female
;
Humans
;
Infant
;
Insufflation
;
Teratoma*
;
Urography
2.Open Reduction and Internal Fixation of the Displaced Fractures of the Acetabulum.
Do Hyun MOON ; Beom Koo LEE ; Jin Hong KO ; Hyoung Ill KIM
The Journal of the Korean Orthopaedic Association 1998;33(4):974-982
Authors reviewed 28 cases of displaced acetabular fracture treated operatively from Februay 1991 to January 1996 and followed up more than 1 year. The clinical results were retrospectively analyzed with consideration of surgical problems and complications. The results were as follows; 1. According to Letournels classification, we had 16 elementary fractures(57%) and 12 associated fractures(43%). 2. Kocher-Langenbeck approach in 16 cases, ilioinguinal in 9 cases, extended iliofemoral 2 cases and combined approach in 1 case were used. 3. The devices for internal fixation were as follows: screw only in 12 cases(elementary fracture 9cases, associated fracture 3 cases), plate and screw in 16 cases(elementary fracture 7 cases, as-sociated fracture 9 cases). 4. There were complications such as 3 degenerative arthritis, 2 superficial wound infection, 1 iatrog-enic sciatic nerve palsy and 1 avascular necrosis of femoral head and no postoperative heterotro-phic ossification. 5. Satisfactory reduction by radiologic criteria was gained in 23 cases(82%). Satisfactory results by clinical criteria(by dAubigne & Postels) was gained in 21 cases(75%). Only 2 patient with a satisfactory radiologic reduction was clinically unsatisfactory. It seems that the satisfactory operative reduction of the fracture is the factor that correlates best with a satisfact-ory clinical result.
Acetabulum*
;
Classification
;
Head
;
Humans
;
Necrosis
;
Osteoarthritis
;
Retrospective Studies
;
Sciatic Neuropathy
;
Wound Infection
3.Effect of ketanserin and positive end expiratory pressure ventilation on hemodynamics and gas exchange in experimental acute pulmonary embolism.
Sang Do LEE ; Young Hyun LEE ; Sung Koo HAN ; Young Soo SHIM ; Keun Youl KIM ; Yong Chol HAN
Tuberculosis and Respiratory Diseases 1993;40(2):135-146
No abstract available.
Hemodynamics*
;
Ketanserin*
;
Positive-Pressure Respiration*
;
Pulmonary Embolism*
;
Ventilation*
4.A Case of Eosinophilia Associated Massive Deep Vein Thrombosis Treated with Local Urokinase Infusion.
In Hyun JUNG ; Donghoon CHOI ; Hye Jin KIM ; Hee Doo KYUNG ; Bon Kwon KOO ; Seung Yun CHO ; Do Yun LEE
Korean Circulation Journal 2001;31(2):256-261
Venous thrombosis is uncommon in young individuals. Hypereosinophilia is a rare cause of thrombosis that usually involves the heart and small vessels like retinal vessels. We report a case of massive deep vein thrombosis that developed in a young patient with hypereosinophilia who was successfully treated with continuous local infusion of urokinase.
Eosinophilia*
;
Heart
;
Humans
;
Retinal Vessels
;
Thrombosis
;
Urokinase-Type Plasminogen Activator*
;
Venous Thrombosis*
5.Microsurgical Anatomy in Transoral Odontoidectomy.
Kwan PARK ; Sang Koo LEE ; Tae Goo CHO ; Jung Il LEE ; Do Hyun NAM ; Jong Soo KIM ; Seung Chyul HONG ; Hyung Jin SHIN ; Whan EOH ; Jong Hyun KIM
Journal of Korean Neurosurgical Society 2000;29(3):309-316
No abstract available.
6.Neuroprotective effect of erythropoietin on anesthesia-induced neurotoxicity through the modulation of autophagy in Caenorhabditis elegans
Bon-Wook KOO ; Hyun-Jung SHIN ; Sooyoung JEON ; Jung Hyun BANG ; Sang-Hwan DO ; Hyo-Seok NA
Korean Journal of Anesthesiology 2024;77(3):384-391
Background:
The anti-oxidative, anti-inflammatory, and anti-apoptotic effects of erythropoietin may provide neuroprotective effects. Erythropoietin also modulates autophagy signaling that may play a role in anesthesia-induced neurotoxicity (AIN). Herein, we investigated whether AIN can be attenuated by the neuroprotective effect of erythropoietin in the Caenorhabditis elegans (C. elegans).
Methods:
Synchronized worms were divided into the control, Iso, EPO, and EPO-Iso groups. The chemotaxis index (CI) was evaluated when they reached the young adult stage. The lgg-1::GFP-positive puncta per seam cell were used to determine the autophagic events. The erythropoietin-mediated pathway of autophagy was determined by measuring the genetic expression level of let-363, bec-1, atg-7, atg-5, and lgg-3.
Results:
Increased lgg-1::GFP puncta were observed in the Iso, EPO, and EPO-Iso groups. In the Iso group, only the let-363 level decreased significantly as compared to that in the control group (P = 0.009). bec-1 (P < 0.001), atg-5 (P = 0.012), and lgg-3 (P < 0.001) were expressed significantly more in the EPO-Iso group than in the Iso groups. Repeated isoflurane exposure during development decreased the CI. Erythropoietin could restore the decreased CI by isoflurane significantly in the EPO-Iso group.
Conclusions
Erythropoietin showed neuroprotective effects against AIN and modulated the autophagic pathway in C. elegans. This experimental evidence of erythropoietin-related neuroprotection against AIN may be correlated with the induced autophagic degradation process that was sufficient for handling enhanced autophagy induction in erythropoietin-treated worms.
7.A Case of Normal Delivery of a Fetus with Prenatally Diagnosed 47,XYY,inv(9)(p11;q13).
Jeong Seo KOO ; Hyun Chul JOO ; Do Keun LEE ; Ji Hye JEON ; Jae Min LEE
Korean Journal of Perinatology 2002;13(2):185-189
A 35-year-old multigravida woman received triple marker screening tests in 16weeks 2days of gestation. MSAFP and MShCG values were increased, whereas MSuE3 value was decreased. So we performed amniocentesis for karyotyping and confirmed male fetus with 47,XYY,inv(9)(p11:q13). A neonatal survey showed the incidence of XYY male to be approximately 1:1000, the majority of cases are phenotypically normal. XYY males are taller than normal and show delayed mental development. A pericenteric inversion of chromosome 9 that extends from p11 to q13 is considered a normal chromosome variant, but the carrier is at high risk to produce abnormal offspring. As she did not want to terminate her pregnancy, she delivered vaginally in 39weeks 6days of gestation. As a result of physical examination, the neonate showed a normal phenotype. We report it with brief review.
Adult
;
Amniocentesis
;
Chromosomes, Human, Pair 9
;
Female
;
Fetus*
;
Humans
;
Incidence
;
Infant, Newborn
;
Karyotyping
;
Male
;
Mass Screening
;
Phenotype
;
Physical Examination
;
Pregnancy
8.Study on Numbers of Cervical Cytology before Diagnosis of Cervical Cancer and Cervical Intraepithelial Neoplasia.
Kae Hyun NAM ; Hae Hyeog LEE ; Kwon Dae KIM ; Jin Woo LEE ; Do Hyeong KOO
Korean Journal of Gynecologic Oncology and Colposcopy 2001;12(2):128-136
OBJECTIVE: Although a great deal of knowledge accumulated with regard to the causes and epidemiologic features of cervical cancer, primary prevention has not been particularly effective to date. Most efforts with regards of control of cervical cancer have been directed toward secondary prevention with cytologic smears in a screening program. The purpose of this study was to know the cervical smear histories in the women with neoplasia of uterine cervix at present. MATERIALS AND METHOD: Between June, 1993 and October, 1996, seventy women with invasive cervical carcinoma and eighty-seven women with cervical intraepithelial neoplasia(CIN) were interviewed about cervical smear histories to assess the frequencies of past smear at the Soonchunhyang University Hospital. RESULTS: The results were follows: 1. The mean age of the women with invasive cervical cancer and CIN were 55+/-9 and 42+/-11, respectively. 2. Of the 70 cases of cervical cancer, 61%(43/70) has not been screened, compared with 43%(37/87) in cases of CIN. 3. The mean ages at first smear in the cases of previous smear were 42+/-6 of 27 cancers, 37+/-7 of 50 CINs. The gap between the age at the first smear and the age at diagnosis were about 6 years in cases of cervical cancers, about 5 years in cases of CIN. 4. The most common symptom in cervical cancers was vaginal bleeding or postcoital bleeding(57%). Although 13%(9/70) were discovered during screening without symptom in the women with cervical cancers, 58%(52/87) were diagnosed incidently during screening in CIN. 5. Pap smear numbers before diagnosis were strongly associated with age and stage. Among women diagnosed with invasive cancer under the age of 49, 75% had at least one cervical smear. But, all women with cervical cancer over age of 65 have not been screened. Unscreened rates of stage I, II, III, and IV were 34%, 78%, 85% and 83% respectively. 6. Among 38 cases who had undergone radiation therapy, 82%(31/38) had not been screen in contrast to 38%(12/32) in the women who had undergone radical surgery. 7. Among women with previous smears in the cervical cancer, 20%(14/70) have been screened within 1year. CONCLUSION: It is likely to diagnosis cervical cancer who had normal papanicolau smear in recent. So papanicolau smear is examined carefully and other adjunctive test is help to diagnosis cervical cancer exactly, for example cervicography, HPV testing.
Cervical Intraepithelial Neoplasia*
;
Cervix Uteri
;
Diagnosis*
;
Female
;
Humans
;
Mass Screening
;
Primary Prevention
;
Secondary Prevention
;
Uterine Cervical Neoplasms*
;
Uterine Hemorrhage
;
Vaginal Smears
9.Endoscopic Ultrasonography-Guided Ethanol Injection for a Pancreatic Neuroendocrine Tumor with Multiple Endocrine Neoplasia Type 1.
Sujong AN ; Jae Yong LEE ; Sung Ha HWANG ; Do Hyun PARK ; Sung Koo LEE
Korean Journal of Pancreas and Biliary Tract 2016;21(4):202-208
Multiple endocrine neoplasia type 1 (MEN1) is a rare inherited disorder caused by mutations in the MEN1 gene on chromosome 1. Clinical diagnostic criteria for MEN1 include the presence of two or more endocrine tumors such as pituitary, parathyroid, and pancreatic islet tumors. Treatment is needed for tumors accompanied by symptoms or having malignant potential. Malignant neuroendocrine tumors (NETs) are the major cause of MEN1-related death, and pancreatic NETs account for 30-80% of MEN1 cases. Surgery is the mainstay curative treatment, and endoscopic intervention is a treatment option when patients are poor candidates for surgery. A 33-year old female patient with MEN1 was treated via endoscopic ultrasonography-guided ethanol injection for a pancreatic NET.
Chromosomes, Human, Pair 1
;
Endosonography
;
Ethanol*
;
Female
;
Humans
;
Islets of Langerhans
;
Multiple Endocrine Neoplasia Type 1*
;
Multiple Endocrine Neoplasia*
;
Neuroendocrine Tumors*
;
Pancreas
10.Endoscopic Ultrasonography-Guided Ethanol Injection for a Pancreatic Neuroendocrine Tumor with Multiple Endocrine Neoplasia Type 1.
Sujong AN ; Jae Yong LEE ; Sung Ha HWANG ; Do Hyun PARK ; Sung Koo LEE
Korean Journal of Pancreas and Biliary Tract 2016;21(4):202-208
Multiple endocrine neoplasia type 1 (MEN1) is a rare inherited disorder caused by mutations in the MEN1 gene on chromosome 1. Clinical diagnostic criteria for MEN1 include the presence of two or more endocrine tumors such as pituitary, parathyroid, and pancreatic islet tumors. Treatment is needed for tumors accompanied by symptoms or having malignant potential. Malignant neuroendocrine tumors (NETs) are the major cause of MEN1-related death, and pancreatic NETs account for 30-80% of MEN1 cases. Surgery is the mainstay curative treatment, and endoscopic intervention is a treatment option when patients are poor candidates for surgery. A 33-year old female patient with MEN1 was treated via endoscopic ultrasonography-guided ethanol injection for a pancreatic NET.
Chromosomes, Human, Pair 1
;
Endosonography
;
Ethanol*
;
Female
;
Humans
;
Islets of Langerhans
;
Multiple Endocrine Neoplasia Type 1*
;
Multiple Endocrine Neoplasia*
;
Neuroendocrine Tumors*
;
Pancreas