Synthetic process fluoroalkylether from artemisinine carried out with 2 TF-DHA and DHA derivatives by etherification reaction with fluoroalkylalcohol in appropriate solvent and catalysis. In research process, author found a catalysis for synthetic reaction of 2 non-flo ethyls of DHA that is sulfuric acid. This catalysis is popular and inexpensive, can replace expensive catalysis in previous experimentations
analogs & derivatives ; pharmacy ; chemistry ; Artemisinins

Beta-Artemether (12beta-O-menthyldihyroartemisinin), a potent antimalarial drug has been synthetised from dihydroartemisinin using nonpolar waterimmiscible solvents and boron trifluorid etherate as a catalyst. Using this methods we always obtain a mixture of beta and alpha artemether with the ratio from 3/1 to 4/1 and the yield of beta-artemether is about 60%. Using polar waterimmiscible solvents in place of nonpolar waterimmiscible solvents in the synthesis can improve the ratio of beta/alpha artemether to 20/1 and the yield of beta-artemether increase to about 70% beta-artemether.
Artemether ; Pharmaceutical Preparations ; therapeutics ; malaria

Artesunate has been produced and used in Vietnam since 1993, but up to 1998, we only produced and used artesunate for tabletting. Since 1998 a research program of injectable artesunate was launched by Ministry of Health. We have succeeded in the production of artesunate powder for injection in two steps: -Producing high quality artesunate powder for injection from the high quality artesunate.
Artesunate ; Pharmaceutical Preparations