Of all fusion techniques in the lumbar spines, posterior lumbar interbody fusion(PLIF) has the best theoretical opportunity to achieve fusion by way of compression loading of the bone graft between the well vascularized vertebral bodies. Even though the rationale for the PLIF is quite reasonable, it has been a very technically demanding procedure and frequent problems have been reported which include protrusion of bone grafts, settling of the interspace and pseudoarthrosis. A new deice, Threaded Fusion Cage(TFC) seems to be an ideal solution for the various technical problems which hindered greater success of PLIF in the past. Maintenance of stability and absence of loss of disc height are assured due to the threaded metal tube concept. We have operated PLIF with TFC in 60 patients since last December. The preoperative diagnoses were 27 degenerative disc diseases, 25 degenerative spondylolisthesis, 7 spondyloysis & listhesis and 1 FBSS. Our initial experience with the clinical results show that the most of the patient have marked improvement of low back pain and reduction is possible in almost cases of the spondylolisthesis. Long term follow up is needed as to the future of the threaded cage, but it would appear that once they have been in a stable position and fusion with the patients' own bone has occurred. In our opinion, the use of TFC in the future will be widely spread and represents an ideal method for the treatment of chronic low back pain and spinal instability.
Diagnosis ; Follow-Up Studies ; Humans ; Low Back Pain ; Pseudarthrosis ; Spine ; Spondylolisthesis ; Transplants

Of all fusion techniques in the lumbar spines, posterior lumbar interbody fusion(PLIF) has the best theoretical opportunity to achieve fusion by way of compression loading of the bone graft between the well vascularized vertebral bodies. Even though the rationale for the PLIF is quite reasonable, it has been a very technically demanding procedure and frequent problems have been reported which include protrusion of bone grafts, settling of the interspace and pseudoarthrosis. A new deice, Threaded Fusion Cage(TFC) seems to be an ideal solution for the various technical problems which hindered greater success of PLIF in the past. Maintenance of stability and absence of loss of disc height are assured due to the threaded metal tube concept. We have operated PLIF with TFC in 60 patients since last December. The preoperative diagnoses were 27 degenerative disc diseases, 25 degenerative spondylolisthesis, 7 spondyloysis & listhesis and 1 FBSS. Our initial experience with the clinical results show that the most of the patient have marked improvement of low back pain and reduction is possible in almost cases of the spondylolisthesis. Long term follow up is needed as to the future of the threaded cage, but it would appear that once they have been in a stable position and fusion with the patients' own bone has occurred. In our opinion, the use of TFC in the future will be widely spread and represents an ideal method for the treatment of chronic low back pain and spinal instability.
Diagnosis ; Follow-Up Studies ; Humans ; Low Back Pain ; Pseudarthrosis ; Spine ; Spondylolisthesis ; Transplants

BACKGROUND/AIMS: Although the viral load is correlated with HBcAg, liver injury was not correlated to viral load in HBeAg positive patient. We aimed to study the inter-relationship of clinical parameters such as the level of HBV-DNA, the level of aminotransferase, intrahepatic expression of HBcAg and severity of histological liver damage in the young male chronic HBV carriers according to HBeAg status. METHODS: The study group included 85 young male patients (mean age: 19.8) with biopsy-proven chronic hepatitis B (HBeAg-positive group: n=60, HBeAg-negative group: n=25). RESUTLS: Serum levels of HBV-DNA and the expression of intrahepatic HBcAg in the HBeAg-positive group were significantly higher than in the HBeAg-negative (p<0.001), but fibrosis score was lower (p<0.01). Serum levels of HBV-DNA positively correlated with lobular activity, portal/periportal activity, biochemical activities in the HBeAg-negative group but negatively correlated in the HBeAg-positive group. There were no significant differences in histological activity according to the pattern of expression of intrahepatic HBcAg in both groups. The lobular activity correlated positively with biochemical activity in both groups, and portal/periportal activity correlated with biochemical activity only in the HBeAg-positive group. CONCLUSIONS: There are close correlations among liver injury, intrahepatic expression of HBcAg, and detectable HBV-DNA in the young male chronic HBV carriers with HBeAg-negativity, but in the HBeAg-positive group, the correlations are diversified.
Adolescent ; Adult ; DNA, Viral/*analysis ; English Abstract ; Hepatitis B Core Antigens/*analysis ; Hepatitis B virus/genetics/*isolation & purification ; Hepatitis B, Chronic/pathology/*virology ; Humans ; Liver/*pathology/virology ; Male ; Viral Load