1.Diagnosis of Overt Disseminated Intravascular Coagulation: A Comparative Study Using Criteria from the International Society Versus the Korean Society on Thrombosis and Hemostasis.
Jong Hwa LEE ; Jae Woo SONG ; Kyung Soon SONG
Yonsei Medical Journal 2007;48(4):595-600
PURPOSE: Since 1993, Koreans have used diagnostic criteria set by the Korean Society on Thrombosis and Hemostasis (KSTH) in the diagnosis of overt disseminated intravascular coagulation (DIC). In 2001, the Scientific and Standardization Committee (SCC) of the International Society on Thrombosis and Hemostasis (ISTH) proposed new diagnostic criteria for the diagnosis of overt DIC. We wanted to compare the use of the ISTH versus KSTH criteria in the diagnosis of overt DIC. MATERIALS AND METHODS: We enrolled 131 patients over the age of 15 years, who had been admitted and diagnosed as having DIC from May 2000 to April 2005 at the Youngdong Severance Hospital, Seoul, Korea. Of the 131 patients, there were 71 males and 60 females, with a median age of 61 years. Hemostatic tests, including platelet counts, PT, aPTT, fibrinogen level and D-dimer, were evaluated based on the respective scoring systems. To assess the concordance between the two diagnostic systems, we used the Student's t-test and the K-coefficient. RESULTS: There were 79 patients compatible with the ISTH criteria and 63 patients with the KSTH criteria. Sixty-one patients were compatible with both diagnostic systems. The grade of agreement, or concordance rate, was 84.7% and the K-coefficient, or interrater reliability, was as low as 0.6 without significance. However, if we scored 1 point for a fibrinogen level of 100-150mg/dL, and 2 points for a level below 100mg/dL, for the ISTH criteria, then 63 patients were compatible with both diagnostic systems, and the concordance rate increased to 85.5% and the K-coefficient to 0.71 with significance. CONCLUSION: To achieve good agreement between the ISTH and KSTH diagnostic systems for overt DIC, we highly recommend changing the plasma fibrinogen cut-off value in the ISTH criteria from 100mg/dL to 150mg/dL and scoring up to 2 points for a level below 100 mg/dL.
Adolescent
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Adult
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Aged
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Aged, 80 and over
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Disseminated Intravascular Coagulation/*diagnosis/etiology/mortality
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Female
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*Hematology
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Humans
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Korea
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Male
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Middle Aged
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Retrospective Studies
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*Societies, Medical
2.Analysis of factors affecting hemorrhagic diathesis and overall survival in patients with acute promyelocytic leukemia.
Ho Jin LEE ; Dong Hyun KIM ; Seul LEE ; Myeong Seok KOH ; So Yeon KIM ; Ji Hyun LEE ; Suee LEE ; Sung Yong OH ; Jin Yeong HAN ; Hyo Jin KIM ; Sung Hyun KIM
The Korean Journal of Internal Medicine 2015;30(6):884-890
BACKGROUND/AIMS: This study investigated whether patients with acute promyelocytic leukemia (APL) truly fulfill the diagnostic criteria of overt disseminated intravascular coagulation (DIC), as proposed by the International Society on Thrombosis and Haemostasis (ISTH) and the Korean Society on Thrombosis and Hemostasis (KSTH), and analyzed which component of the criteria most contributes to bleeding diathesis. METHODS: A single-center retrospective analysis was conducted on newly diagnosed APL patients between January 1995 and May 2012. RESULTS: A total of 46 newly diagnosed APL patients were analyzed. Of these, 27 patients (58.7%) showed initial bleeding. The median number of points per patient fulfilling the diagnostic criteria of overt DIC by the ISTH and the KSTH was 5 (range, 1 to 7) and 3 (range, 1 to 4), respectively. At diagnosis of APL, 22 patients (47.8%) fulfilled the overt DIC diagnostic criteria by either the ISTH or KSTH. In multivariate analysis of the ISTH or KSTH diagnostic criteria for overt DIC, the initial fibrinogen level was the only statistically significant factor associated with initial bleeding (p = 0.035), but it was not associated with overall survival (OS). CONCLUSIONS: Initial fibrinogen level is associated with initial presentation of bleeding of APL patients, but does not affect OS.
Adult
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Aged
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Biomarkers/blood
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Chi-Square Distribution
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Disseminated Intravascular Coagulation/blood/diagnosis/*etiology/mortality
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Female
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Fibrinogen/analysis
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Hemorrhagic Disorders/blood/diagnosis/*etiology/mortality
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Humans
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Kaplan-Meier Estimate
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Leukemia, Promyelocytic, Acute/blood/*complications/diagnosis/mortality
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Logistic Models
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Male
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Middle Aged
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Multivariate Analysis
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Proportional Hazards Models
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Republic of Korea
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Retrospective Studies
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Risk Factors
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Young Adult