As a common Tibetan medicine, Potentilla anserine L. is a kind of important Chinese materia medica, which is mainly distributed in Gansu, Qinghai and Tibet Provinces. As the active constituent from Potentilla anserine L., potentilla anserine polysaccharide has received initial research by researchers in abroad and at home. It is suggested that potentilla anserine polysaccharide exhibits various functions including antioxidation, anti-aging, immunoregulation, inhibiting bacteria and anti-diabetic. This article reviewed the research on extraction, purification and bioactivities of potentilla anserine polysaccharide, which is expected to provide ideas for the further study and research and development.

Objective To explore the effect of childhood trauma on escitalopram treatment of adult depression. Methods There were 68 adult patients with major depression disorder recruited. All patients were assessed with Childhood Trauma Questionnaire ( CTQ ) and given 8 weeks of standardized treatment with escitalopram. Beck Depression Inventory ( BDI) and HAMD-17 were assessed at the end of the 2nd,4th and 8th week respectively. The changes of BDI score and HAMD-17 score in patients with different CTQ fac-tors were observed. Results ( 1) The overall effect of intervention was 25. 0％ at the end of 4th week and 45. 6％ at the end of 8th week. The total effective rate was 94. 1％. At the end of 4th week,there was no sig-nificant difference in the clinical recovery rate between the positive group(19. 5％) and the negative group (33. 3％)(χ2=1. 66,P>0. 05). There was no significant difference in clinical recovery between the two groups at the end of 8th week(positive group :39. 0％,negative group :55. 6％,χ2=1. 79,P>0. 05). (2) The total score reduction rate of HAMD-17((46. 26±24. 79)％,(58. 39±23. 25)％) and BDI((51. 63± 16. 03)％,(66. 28±18. 05)％) at the end of 4th week and the total score reduction rate of BDI at the end of 8th week ((59. 13±15. 42)％,(68. 50±20. 91)％)in the positive group were lower than those in the nega-tive group (P<0. 05) . ( 3) Except for sexual abuse,there was a significant negative correlation between CTQ scores and the reduction rate of BDI scores at end of 4th and 8th week( r=-0. 46--0. 06,P<0. 05) . Conclu-sion Childhood trauma has adverse effects on the efficacy of escitalopram in the treatment of adult depres-sion.

Objective:To explore the effect of match between childhood stress and adulthood stress on mental health status.Methods:Adult healthy volunteers( n=239) and adult mental disorder patients were examined by questionnaires or telephone interviews.Childhood trauma questionnaire (CTQ) and lifetime stress event list were used for measure of CS and AS, DSM5-level-1-cross-cutting-symptom-measure (DSM5-L1CCSM) and self-rating depression scale (SDS) for mental health outcomes.Subjects were grouped according to positive (+ ) / negative (-) stress events into five groups: CS+ AS+ Matched ( n=108), CS+ AS+ mismatched( n=240), CS-AS+ ( n=100), CS+ AS-( n=79), and CS-AS-( n=99). The data of stress and mental health status were compared and analyzed among stress groups. Results:The distributions of positive stress events among 626 volunteers were 68.2% with CS+ , 71.6% with AS+ , 17.3% with C+ A+ M+ .There were differences among groups in all parameters (all P<0.05) except for gender.Age, years of education, CS and emotional abuse were influencing factors of onset of AS( P<0.01). MANCOVA analysis showed that factors about the interaction of AS and CS had attribution on DSM5-L1CCSM and SDS ( P<0.01). Conclusion:CS has a facilitatory effect on AS.The match of CS-AS is an important risk factor of adulthood mental health outcomes.Re-experiencing the same type of CS in adulthood would worsen adulthood mental health status.