Objective To investigate the value of detection of serum LDH,AST,CK and LDH and TNF-α of CSF in the acute phase of adult intracranial infection.Methods Seventy-seven patients with acute stage of intracranial infection in our hospital from January 2014 to December 2015 were selected as the observation group,and 60 patients with non-infectious nervous system diseases were selected as the control group.The levels of serum LDH,AST and CK,and LDH and TNF-α levels of CSF within 7 d after onset were compared between the two groups and the subgroup analysis was performed.Results The levels of serum LDH,AST and CK,and TNF-α and LDH of CSF in the infection group were significantly higher than those in the control group,the difference was statistically significant (P＜0.05);LDH level of CSF in the purulent meningitis and tuberculous meningitis groups was significantly higher than that in the viral encephalitis group (P＜0.05);the level of TNF-α of CSF in the purulent meningitis was significantly higher than that in the tuberculous meningitis and viral meningitis groups (P＜0.05).Conclsion Detecting serum LDH,AST and CK,and LDH and TNF-α levels of CSF is conducive to the auxiliary diagnosis of intracranial infection,meanwhile has a certain discriminating value for the causes of intracranial infection.

OBJECTIVE:To investigate the effects of mannitol combined with dexamethasone on related indexes of patients with infectious brain edema.METHODS:A total of 120 patients with infectious cerebral edema were divided into control group (60 cases) and observation group (60 cases) according to therapy plan.Control group was given Furosemide injection 20 mg+20％ Mannitol injection 1 g/(kg,time)+0.9％ Sodium chloride injection 10 mL intravenously,every 6 h,3 days later adjusting drug dose according to the disease condition of patients.Observation group was given Dexamethasone injection 10-20 mg+20％ Mannitol injection 1 g/(kg·time)+ 0.9％ Sodium chloride injection 10 mL intravenously,every 6 h,3 days later adjusting drug dose according to the disease condition of patients.A treatment course lasted for 7 d,and both groups were treated for 2 courses of treatment.The levels of NO,IL-1 and TNF-α,mortality and the occurrence of sequelae before and after treatment as well as the occurrence of ADR were observed in 2 groups.RESULTS:Before treatment,there was no statistical significance in the levels of NO,IL-1 or TNF-α between 2 groups (P＞0.05).After treatment,the levels of NO,IL-1 and TNF-α in 2 groups were significantly lower than before treatment,and the observation group was significantly lower than the control group,with statistical significance (P＜0.05).The incidence of mortality,sequelae and ADR in observation group were significantly lower than control group,with statistical significance (P＜0.05).CONCLUSIONS:Mannitol combined with dexamethasone can reduce inflammatory factor level,the incidence of sequelae and mortality,without increasing the incidence of ADR.