Objective　To investigate the effect of Salvianolic acid on the expression of glial fibrillary acidic protein (GFAP),protein gene product (PGP9.5),IL-5,IL-6,IL-8,IL-10 and prognosis in patients with acute ischemic stroke.Methods　84 patients with acute ischemic stroke were divided into salvia miltiorrhiza group (n=42) and control group (n=42).Barthel index and NIHSS score were performed on the day of admission and 14 days.The post-infarction volume was calculated and compared after head MRI.The expression levels of serum GFAP,PGP9.5,IL-5,IL-6,IL-8 and IL-10 were detected and compared by magnetic particle chemiluminescence method.The prognosis was determined by modified Rankin score (mRS) 90 days after infarction.Results　After treatment,NIHSS score,Barthel index and infarct volume in salvia miltiorrhiza group were significantly decreased (P<0.05),significantly increased (P<0.05) and significantly decreased (P<0.05).GFAP,IL-6 and IL-8 decreased significantly in salvia miltiorrhiza group after treatment compared with the control group (all P<0.05).After treatment,IL-10 expression level in salvia miltiorrhiza group increased more significantly than that in control group (P<0.05).The prognosis of Salvia miltiorrhiza group was better than that of control group (P<0.05).Conclusion　Salvianolic acid in the treatment of acute ischemic stroke can effectively inhibit inflammatory reaction,reduce brain injury,improve neurological impairment,improve daily behavior and improve prognosis.