1.The application advances of bisphosphonates in bone metastasis.
China Journal of Orthopaedics and Traumatology 2008;21(6):480-482
Bone metastases is a serious complication of patients with tumor. It is associated with substantial morbidity, including bone pain, pathological fracture,neurological deficit and (or) hypercalcemia. Thus, the management of bone metastasis is a clinically significant issue. Bisphosphonates have now become a part of standard therapy to treat and prevent skeletal-related events (SRE), it could inhibit osteoclast-mediated bone resorption and demonstrate antitumor activity in preclinical models. Bisphosphonates are the most effective agent for treating and (or) preventing complications of bone metastasis, reducing the incidence of skeletal-related events, and improving quality of life in patients with bone metastasis.
Apoptosis
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drug effects
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Bone Neoplasms
;
drug therapy
;
pathology
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secondary
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Diphosphonates
;
adverse effects
;
pharmacology
;
therapeutic use
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Humans
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Neoplasm Invasiveness
2.Spontaneous Acetabular Periprosthetic Fracture in a Patient Continuously Having Zoledronic Acid.
Saran TANTAVISUT ; Aree TANAVALEE ; Voranuch THANAKIT ; Srihatach NGARMUKOS ; Vajara WILAIRATANA ; Yongsak WANGROONGSUB
Clinics in Orthopedic Surgery 2014;6(3):358-360
Zoledronic acid has been used for prevention of osteolytic and osteoblastic bone metastasis. This case report illustrates an undesirable consequence from prolonged usage of zoledronic acid in bone metastasis prevention. Periprosthetic acetabular fracture in a patient treated with zoledronic acid for 7 years was reported. The clinical presentation, radiographic and pathological results were described. This is a rare complication after total hip arthroplasty which should not be ignored especially in patients who received long term bisphosphonate.
Acetabulum/*injuries/pathology/surgery
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Aged
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Arthroplasty, Replacement, Hip/*adverse effects
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Bone Density Conservation Agents/*adverse effects/pharmacology
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Bone Neoplasms/prevention & control/secondary
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Bone Remodeling/drug effects
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Breast Neoplasms/pathology
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Diphosphonates/*adverse effects/pharmacology
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Female
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Fractures, Spontaneous/chemically induced/etiology
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Hip Prosthesis
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Humans
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Imidazoles/*adverse effects/pharmacology
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Osteoarthritis, Hip/*surgery
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Periprosthetic Fractures/*chemically induced/etiology
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Prosthesis Failure
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Reoperation