Safety literatures on Rhizoma Dioscoreae bulbiferae and oral preparation have been reviewed and analyzed systematically, including textual research for origin and varieties, ancient and modern toxic record and toxic empirical study. Characteristics of clinical manifestations, risk factors and latest findings related to Rhizoma Dioscoreae bulbiferae have been concluded initially. The following measures may be effective for risk control and improving efficacy of Rhizoma Dioscoreae bulbiferae: to develope post-marketed evaluation actively; to regulate clinical medication; to strengthen safety-related basic study including the basis of toxic substances, toxic mechanism, efficacy enhancing and toxicity reducing etc.
Dioscorea ; chemistry ; Drug Therapy ; Drug-Related Side Effects and Adverse Reactions ; Drugs, Chinese Herbal ; administration & dosage ; adverse effects ; analysis ; Female ; Humans ; Middle Aged ; Rhizome ; chemistry

Some herbal medications induce acute kidney injury. The acute kidney injuries caused by herbal medications are mild and commonly treated by palliative care. A 51-years-old man who drank the juice squeezed from the raw tubers of Dioscorea quinqueloba (D. quinqueloba) was admitted with nausea, vomiting and chilling. He developed a seizure with decreased level of consciousness. He was diagnosed with acute kidney injury, which was cured by continuous venovenous hemodialfiltration. Non-detoxified D. quinqueloba can cause severe acute kidney injury with toxic encephalopathy. It is critical to inform possible adverse effects of the medicinal herbs and to implement more strict regulation of these products.
Acute Kidney Injury/*chemically induced/*complications ; Dioscorea/*adverse effects ; Disease Progression ; Electroencephalography ; Humans ; Length of Stay ; Male ; Middle Aged ; Neurotoxicity Syndromes/*complications