No abstract available.
Dinoprost* ; Female ; Pregnancy ; Pregnancy, Tubal*

No abstract available.
Dinoprost* ; Flurbiprofen* ; Gabexate* ; Prednisolone* ; Thromboxane B2*

No abstract available.
Dinoprost* ; Female ; Laparoscopes* ; Pregnancy ; Pregnancy, Tubal*

The transient acute severe hypertensions with arrhrthmia after intramrometrial injection of Img PGF2 alpha during cesarean section by means of spinal as well as general anestheaia are returned to normal limit of vital sings without special treatment. Ne specific complications were experienced following the episode until discharge.
Cesarean Section ; Dinoprost* ; Female ; Hypertension* ; Pregnancy

PURPOSE: The purpose of this study was to identify effects of Artemisia A. Smoke(Ssukjahun) on primary dysmenorrhea. METHOD: This study was a pretestposttest design with a nonequivalent control group. Data were collected from May 1, 2007 to May 27, 2008. A total of 40 women with dysmenorrhea participated in the study. Among them, 20 women were assigned to an experimental group and the other 20 to a control group. Artemisia A. Smoke(Ssukjahun) was provided daily for 4 days, starting 7 days prior to next expected menses in the experimental group. The instruments used in this study included MDQ (Moos' Menstrual Distress Questionnaire) by Kim (1995), Visual Analogue Scale by Keele (1948), and PGF2alpha by urine. RESULT: The results of this study are as follows; The experimental group was lower than the control group in the degree of menstrual distress (t=5.25, p=0.000), intensity of dysmenorrhea (t=7.71, p=0.000), and prostaglandin F2alpha levels (t=4.56, p=0.000). CONCLUSION: Artemisia A. Smoke (Ssukjahun) was proved as an effective nursing intervention to reduce dysmenorrhea in young women. Its convenience and accessibility may make it a useful intervention in nursing practice and education.
Artemisia ; Dinoprost ; Dysmenorrhea ; Female ; Humans ; Smoke

PURPOSE: To investigate the effect of latanoprost on the melanogenesis and endogenous PG release. METHODS: Primarily cultured uveal human melanocytes were exposed to 0.1 micrometer, 1 micrometer, and 10 micrometer of PhXA85 and also co-exposured with 1 micrometer of indomethacine or hydrocortisone, the melanin content of each melanocyte was measured with spectrophotometer after 1 week. RESULTS: After 1 week, the melanin content of each melanocyte was increased with 1 micrometer, 10 micrometer of PhXA85(p<0.05). After co-exposure with indomethacine or hydrocortisone, the amount of increased melanin content was less than that of PhXA85 alone and statistically significant with 10 micrometer of PhXA85(p<0.05). CONCLUSIONS: These results show that PhXA85 stimulates melanogenesis of cultured human uveal mela-nocytes and also suggests the possibility of exogenous PGF2 alpha-induced release of endogenous prostaglandin.
Dinoprost ; Humans* ; Hydrocortisone ; Indomethacin ; Melanins ; Melanocytes*

PURPOSE: Intracerebroventricular injection of prostaglandin(PG) in the central nervous system is accompanied by a decrease in convulsions, a modulation of recurrences of seizures. Therefore, we observed the change of prostaglandin F2alpha(PGF2alpha) according to temperatures in the first febrile convulsions, and the relationship between the recurrence of febrile convulsions. METHODS: 93 patients with febrile convulsions recurrence could be studied for 42 months. All CSF samples were analyzed. During febrile convulsions, no anticonvulsant was used. We analyzed the recurrences of febrile convulsion according to PGF2alpha levels. RESULTS: The levels of PGF2alpha during 3 months recurrence group were 194.9+/-89.7 pg/mL, those during 4-6 months were 224.0+/-104.4 pg/mL, those during 7-9 months were 101.9+/-46.0 pg/mL, those during 10-12 months were 195.7+/-77.5 pg/mL, those during 13-18 months were 182.4+/-91.1 pg/mL, those during 19-24 months were 359.8+/-284.1 pg/mL, those during 25-36 months were 215.5+/-14.8 pg/mL and those during 37-42 months were 191.5+/-5.0 pg/mL. CONCLUSION: Elevated concentrations of PGF2alpha in febrile convulsions were found and not related to the increasing rate of fever. In the recurrent groups of febrile convulsions, there was no relationship between PGF2alpha levels and recurrences time of febrile convulsions except 7-9 months recurrence group. Although the exact mechanism of recurrence of febrile convulsion is unclear, we think that more consistent study of this recurrence is important to clarify the role of prostaglandin in the first febrile convulsion and the relationship to recurrences of febrile convulsions.
Central Nervous System ; Dinoprost* ; Fever ; Humans ; Recurrence* ; Seizures ; Seizures, Febrile*

OBJECTIVE: The aim was to evaluate whether the differences of PG concentration in follicular and peritoneal fluid during preovulatory phase exist between the women with and without endometriosis. MATERIAL AND METHODS: Twenty-three patients with endometriosis, 8 were stage I-II and 15 were stage III-IV, and another 23 patients without endometriosis were undergone laparotomy during late follicular phase. Peritoneal fluid from 46 patients and follicular fluid from 42 patients were obtained, and these samples were analyzed double times for PGF2alpha, PGE2 and estradiol. RESULTS: The mean level of PGF2alphain the peritoneal fluid was significantly higher in the group with endometriosis than in the control(P=0.0293), especially more significant in stage I-II endometriosis. Although there was no significant difference of PGF2alphaconcentration in the follicular fluid between the groups, the stage III-IV endometriosis group showed slightly higher PGF2alphalevel than both the stage I-II group and the control(P=0.0604). And also, there was significant positive correlation with the level of PGF2alphaand estradiol in the follicular fluid only in the endometriosis group(r=0.4988, P=0.0154), not in the control. However, there was no difference in the level of PGE2 and estradiol in the peritoneal or follicular fluid between the groups. CONCLUSION: Some alterations of PGF2alphalevel exist in the women with endometriosis. These are significantly higher PGF2alphalevel in peritoneal fluid with mild endometriosis and slightly higher PGF2alphalevels in follicular fluid with extensive endometriosis during preovulatory phase, which suggest that PGF2alphamay play some roles in subfertility associated with endometriosis.
Ascitic Fluid* ; Dinoprost* ; Dinoprostone ; Endometriosis* ; Estradiol ; Female ; Follicular Fluid ; Follicular Phase* ; Humans ; Infertility ; Laparotomy

PURPOSE: To investigate whether prostaglandin F2alpha (PGF2alpha) affects on the production of nitric oxide (NO) in cultured ciliary muscle (CM) cells. METHODS: Following primary culture of CM cells from porcine eyes, the cells were exposed to PGF2alpha (PhXA85, latanoprost free acid) with and without pretreatments of NO synthase inhibitor (L-NAME, N omega- Nitro-L-arginine methyl ester) and cyclooxygenase inhibitors (indomethacin and dexamethasone) for 3 days. The cellular survivals were also evaluated in serum-deprived and hypoxic conditions induced by sodium cyanide. The cellular survival and nitrite production were assessed by MTT and Griess assay, respectively. RESULTS: PGF2alpha enhanced the production of NO significantly in cultured CM cells in a dose-dependent manner, while various inhibitors abolished this effect. PGF2alpha was not cytoprotective in serum-deprived and hypoxic conditions. CONCLUSIONS: The current results suggest that PGF2alpha potentiates NO production but is not cytoprotective in CM cells. This PGF2alpha-induced NO production in CM cells may be involved in the regulation of uveoscleral outflow.
Cyclooxygenase Inhibitors ; Dinoprost* ; Muscle Cells* ; Nitric Oxide Synthase ; Nitric Oxide* ; Sodium Cyanide

This study was performed to investigate the stimulating effect on oocyte maturation and cumulus cell expansion in TC199 media by human cord serum (HCS) supplementation. Immature mouse oocyte cumulus complexes (OCCs) were cultured in TC199 media supplemented with bovine serum albumin (BSA), HCS and human chorionic gonadotropin (hCG) instead of luteinizing hormone (LH) respectively, and the expression of cumulus expansion and oocyte maturation were observed. After 4hr and 24hr culture with or without OCCs, media containing 0.4% BSA, 10% HCS and 10 lU hCG respectively were collected and analyzed for changing concentrations of estradiol (E2), progesterone(P4), testosterone(T), and PGF2. There were no elevation of E2, T, and PGF2 by OCCs culture, but minute elevation of P4 level by 24hr OCCs culture in hCG supplementation (p=0.048). The stimulating pattern of cumulus expansion of OCCs by HCS and hCG supplementation was similar to our previously report using Ham's F-10 media, however oocyte maturation rates after 24hr OCCs culture in all media were increased by 20~30% compared to Ham's F-10 media. These results suggest that LH in HCS induce cumulus expansion probably by P4 secretion of OCCs, and TC199 is efficient media for immature mouse oocyte maturation.
Animals ; Chorionic Gonadotropin ; Cumulus Cells* ; Dinoprost ; Estradiol ; Humans* ; Luteinizing Hormone ; Mice ; Oocytes* ; Serum Albumin, Bovine