No abstract available.
Dinoprost* ; Female ; Pregnancy ; Pregnancy, Tubal*

PURPOSE: To investigate the effect of latanoprost on the melanogenesis and endogenous PG release. METHODS: Primarily cultured uveal human melanocytes were exposed to 0.1 micrometer, 1 micrometer, and 10 micrometer of PhXA85 and also co-exposured with 1 micrometer of indomethacine or hydrocortisone, the melanin content of each melanocyte was measured with spectrophotometer after 1 week. RESULTS: After 1 week, the melanin content of each melanocyte was increased with 1 micrometer, 10 micrometer of PhXA85(p<0.05). After co-exposure with indomethacine or hydrocortisone, the amount of increased melanin content was less than that of PhXA85 alone and statistically significant with 10 micrometer of PhXA85(p<0.05). CONCLUSIONS: These results show that PhXA85 stimulates melanogenesis of cultured human uveal mela-nocytes and also suggests the possibility of exogenous PGF2 alpha-induced release of endogenous prostaglandin.
Dinoprost ; Humans* ; Hydrocortisone ; Indomethacin ; Melanins ; Melanocytes*

No abstract available.
Dinoprost* ; Flurbiprofen* ; Gabexate* ; Prednisolone* ; Thromboxane B2*

PURPOSE: The purpose of this study was to identify effects of Artemisia A. Smoke(Ssukjahun) on primary dysmenorrhea. METHOD: This study was a pretestposttest design with a nonequivalent control group. Data were collected from May 1, 2007 to May 27, 2008. A total of 40 women with dysmenorrhea participated in the study. Among them, 20 women were assigned to an experimental group and the other 20 to a control group. Artemisia A. Smoke(Ssukjahun) was provided daily for 4 days, starting 7 days prior to next expected menses in the experimental group. The instruments used in this study included MDQ (Moos' Menstrual Distress Questionnaire) by Kim (1995), Visual Analogue Scale by Keele (1948), and PGF2alpha by urine. RESULT: The results of this study are as follows; The experimental group was lower than the control group in the degree of menstrual distress (t=5.25, p=0.000), intensity of dysmenorrhea (t=7.71, p=0.000), and prostaglandin F2alpha levels (t=4.56, p=0.000). CONCLUSION: Artemisia A. Smoke (Ssukjahun) was proved as an effective nursing intervention to reduce dysmenorrhea in young women. Its convenience and accessibility may make it a useful intervention in nursing practice and education.
Artemisia ; Dinoprost ; Dysmenorrhea ; Female ; Humans ; Smoke

The transient acute severe hypertensions with arrhrthmia after intramrometrial injection of Img PGF2 alpha during cesarean section by means of spinal as well as general anestheaia are returned to normal limit of vital sings without special treatment. Ne specific complications were experienced following the episode until discharge.
Cesarean Section ; Dinoprost* ; Female ; Hypertension* ; Pregnancy

No abstract available.
Dinoprost* ; Female ; Laparoscopes* ; Pregnancy ; Pregnancy, Tubal*

PURPOSE: Intracerebroventricular injection of prostaglandin(PG) in the central nervous system is accompanied by a decrease in convulsions, a modulation of recurrences of seizures. Therefore, we observed the change of prostaglandin F2alpha(PGF2alpha) according to temperatures in the first febrile convulsions, and the relationship between the recurrence of febrile convulsions. METHODS: 93 patients with febrile convulsions recurrence could be studied for 42 months. All CSF samples were analyzed. During febrile convulsions, no anticonvulsant was used. We analyzed the recurrences of febrile convulsion according to PGF2alpha levels. RESULTS: The levels of PGF2alpha during 3 months recurrence group were 194.9+/-89.7 pg/mL, those during 4-6 months were 224.0+/-104.4 pg/mL, those during 7-9 months were 101.9+/-46.0 pg/mL, those during 10-12 months were 195.7+/-77.5 pg/mL, those during 13-18 months were 182.4+/-91.1 pg/mL, those during 19-24 months were 359.8+/-284.1 pg/mL, those during 25-36 months were 215.5+/-14.8 pg/mL and those during 37-42 months were 191.5+/-5.0 pg/mL. CONCLUSION: Elevated concentrations of PGF2alpha in febrile convulsions were found and not related to the increasing rate of fever. In the recurrent groups of febrile convulsions, there was no relationship between PGF2alpha levels and recurrences time of febrile convulsions except 7-9 months recurrence group. Although the exact mechanism of recurrence of febrile convulsion is unclear, we think that more consistent study of this recurrence is important to clarify the role of prostaglandin in the first febrile convulsion and the relationship to recurrences of febrile convulsions.
Central Nervous System ; Dinoprost* ; Fever ; Humans ; Recurrence* ; Seizures ; Seizures, Febrile*

This study was performed to investigate the stimulating effect on oocyte maturation and cumulus cell expansion in TC199 media by human cord serum (HCS) supplementation. Immature mouse oocyte cumulus complexes (OCCs) were cultured in TC199 media supplemented with bovine serum albumin (BSA), HCS and human chorionic gonadotropin (hCG) instead of luteinizing hormone (LH) respectively, and the expression of cumulus expansion and oocyte maturation were observed. After 4hr and 24hr culture with or without OCCs, media containing 0.4% BSA, 10% HCS and 10 lU hCG respectively were collected and analyzed for changing concentrations of estradiol (E2), progesterone(P4), testosterone(T), and PGF2. There were no elevation of E2, T, and PGF2 by OCCs culture, but minute elevation of P4 level by 24hr OCCs culture in hCG supplementation (p=0.048). The stimulating pattern of cumulus expansion of OCCs by HCS and hCG supplementation was similar to our previously report using Ham's F-10 media, however oocyte maturation rates after 24hr OCCs culture in all media were increased by 20~30% compared to Ham's F-10 media. These results suggest that LH in HCS induce cumulus expansion probably by P4 secretion of OCCs, and TC199 is efficient media for immature mouse oocyte maturation.
Animals ; Chorionic Gonadotropin ; Cumulus Cells* ; Dinoprost ; Estradiol ; Humans* ; Luteinizing Hormone ; Mice ; Oocytes* ; Serum Albumin, Bovine

OBJECTIVE: Postpartum hemorrhage is most common cause of maternal mortality. Active management of third stage of labor minimizes the risk of postpartum hemorrhage. To compare the effect of methylergonovine and 15-methyl prostaglandin F2alpha (15-methyl PGF2alpha) in active management of third stage of labor. METHODS: A randomized open labelled parallel study with 50 women in normal labor, 25 in each group were included. The drugs methylergonovine (0.2 mg) intravenous and 15-methyl PGF2alpha (250 microg) intramuscular were administered at the time of delivery of anterior shoulder. Main outcomes measured were amount of blood loss during the first four hours of delivery and objective measurement of hemoglobin and hematocrit levels before delivery and third day postpartum. RESULTS: There was no statistically significant difference in the blood loss between the two groups at delivery (P = 0.130), at 1 hour of delivery (P = 0.453). The blood loss with 15-methyl PGF2alpha was significantly less as compared to that of blood loss with methylergonovine at four hours of delivery (P = 0.014) and the total, i.e., during first four hours, amount of blood loss was significantly less with 15-methyl PGF2alpha (P = 0.026). There was no statistically significant difference in the hemoglobin and hematocrit levels measured predelivery and postpartum third day between both the drugs. CONCLUSION: Both the drugs were effective in controlling the amount of blood loss during the third stage of labor, 15-methyl PGF2alpha being more efficacious.
Dinoprost ; Female ; Hematocrit ; Hemoglobins ; Humans ; Maternal Mortality ; Methylergonovine ; Postpartum Hemorrhage ; Postpartum Period ; Shoulder

Preliminary in vitro experiments were performed to define the contraction effects of the serotonin and prostaglandin F2 alpha in cat's internal carotid artery. Subsquently 12 cats were used to study changes in contractility resulting from pretreatment with reserpine. The arteries, which were exposed to serotonin and prostaglandin F2 alpha contracted significantly just after exposure time. And by addition of higher concentrated serotonin and prostaglandin F2 alpha more contractions were noted. Arteries isolated from reserpine-pretreated cats responded to the serotonin and prostaglandin F2 alpha with similar pattern to those seen in control groups, but the contractility showed some what more decreased slope compared to those with high concentration of serotonin only. These results suggested that reserpine might have yet unknown effects which were different from known mechnism of serotonin to cerebral arteries.
Animals ; Arteries ; Carotid Artery, Internal ; Cats ; Cerebral Arteries ; Dinoprost ; Reserpine* ; Serotonin