No abstract available.
Dinoprost* ; Female ; Pregnancy ; Pregnancy, Tubal*

No abstract available.
Dinoprost* ; Flurbiprofen* ; Gabexate* ; Prednisolone* ; Thromboxane B2*

PURPOSE: To investigate the effect of latanoprost on the melanogenesis and endogenous PG release. METHODS: Primarily cultured uveal human melanocytes were exposed to 0.1 micrometer, 1 micrometer, and 10 micrometer of PhXA85 and also co-exposured with 1 micrometer of indomethacine or hydrocortisone, the melanin content of each melanocyte was measured with spectrophotometer after 1 week. RESULTS: After 1 week, the melanin content of each melanocyte was increased with 1 micrometer, 10 micrometer of PhXA85(p<0.05). After co-exposure with indomethacine or hydrocortisone, the amount of increased melanin content was less than that of PhXA85 alone and statistically significant with 10 micrometer of PhXA85(p<0.05). CONCLUSIONS: These results show that PhXA85 stimulates melanogenesis of cultured human uveal mela-nocytes and also suggests the possibility of exogenous PGF2 alpha-induced release of endogenous prostaglandin.
Dinoprost ; Humans* ; Hydrocortisone ; Indomethacin ; Melanins ; Melanocytes*

PURPOSE: The purpose of this study was to identify effects of Artemisia A. Smoke(Ssukjahun) on primary dysmenorrhea. METHOD: This study was a pretestposttest design with a nonequivalent control group. Data were collected from May 1, 2007 to May 27, 2008. A total of 40 women with dysmenorrhea participated in the study. Among them, 20 women were assigned to an experimental group and the other 20 to a control group. Artemisia A. Smoke(Ssukjahun) was provided daily for 4 days, starting 7 days prior to next expected menses in the experimental group. The instruments used in this study included MDQ (Moos' Menstrual Distress Questionnaire) by Kim (1995), Visual Analogue Scale by Keele (1948), and PGF2alpha by urine. RESULT: The results of this study are as follows; The experimental group was lower than the control group in the degree of menstrual distress (t=5.25, p=0.000), intensity of dysmenorrhea (t=7.71, p=0.000), and prostaglandin F2alpha levels (t=4.56, p=0.000). CONCLUSION: Artemisia A. Smoke (Ssukjahun) was proved as an effective nursing intervention to reduce dysmenorrhea in young women. Its convenience and accessibility may make it a useful intervention in nursing practice and education.
Artemisia ; Dinoprost ; Dysmenorrhea ; Female ; Humans ; Smoke

The transient acute severe hypertensions with arrhrthmia after intramrometrial injection of Img PGF2 alpha during cesarean section by means of spinal as well as general anestheaia are returned to normal limit of vital sings without special treatment. Ne specific complications were experienced following the episode until discharge.
Cesarean Section ; Dinoprost* ; Female ; Hypertension* ; Pregnancy

No abstract available.
Dinoprost* ; Female ; Laparoscopes* ; Pregnancy ; Pregnancy, Tubal*

PURPOSE: Intracerebroventricular injection of prostaglandin(PG) in the central nervous system is accompanied by a decrease in convulsions, a modulation of recurrences of seizures. Therefore, we observed the change of prostaglandin F2alpha(PGF2alpha) according to temperatures in the first febrile convulsions, and the relationship between the recurrence of febrile convulsions. METHODS: 93 patients with febrile convulsions recurrence could be studied for 42 months. All CSF samples were analyzed. During febrile convulsions, no anticonvulsant was used. We analyzed the recurrences of febrile convulsion according to PGF2alpha levels. RESULTS: The levels of PGF2alpha during 3 months recurrence group were 194.9+/-89.7 pg/mL, those during 4-6 months were 224.0+/-104.4 pg/mL, those during 7-9 months were 101.9+/-46.0 pg/mL, those during 10-12 months were 195.7+/-77.5 pg/mL, those during 13-18 months were 182.4+/-91.1 pg/mL, those during 19-24 months were 359.8+/-284.1 pg/mL, those during 25-36 months were 215.5+/-14.8 pg/mL and those during 37-42 months were 191.5+/-5.0 pg/mL. CONCLUSION: Elevated concentrations of PGF2alpha in febrile convulsions were found and not related to the increasing rate of fever. In the recurrent groups of febrile convulsions, there was no relationship between PGF2alpha levels and recurrences time of febrile convulsions except 7-9 months recurrence group. Although the exact mechanism of recurrence of febrile convulsion is unclear, we think that more consistent study of this recurrence is important to clarify the role of prostaglandin in the first febrile convulsion and the relationship to recurrences of febrile convulsions.
Central Nervous System ; Dinoprost* ; Fever ; Humans ; Recurrence* ; Seizures ; Seizures, Febrile*

OBJECTIVETo observe the clinical curative effect of primary dysmenorrhea and the content of prostaglandin F2alpha (PGF2alpha) in peripheral blood of menstrual periods treated with eye acupuncture therapy.

METHODSOne hundred and ten cases of primary dysmenorrhea were randomly divided into an eye acupuncture group (60 cases) and a medication group (50 cases). In eye acupuncture group, low energizer area, liver area, kidney area, heart area and spleen area etc. were selected according to the differentiation, and the eye acupuncture therapy was applied. In medication group, Ibuprofen Sustained Release Capsules was taken with oral administration for 300 mg 1-2 days before menses coming or when the symptoms appeared, once every 12 hours, for 3-5 days totally. Three menstrual periods made one session. The content of PGF2alpha in peripheral blood, and the curative effects and recurrence 3 and 6 months after treatment were observed.

RESULTSAfter 3 months treatment, compared with the curative effects between both groups, the cured rate was 55.0% (33/60) and the total effective rate was 95.0% (57/60) in eye acupuncture group, which were superior to those of 34.0% (17/50) and 82.0% (41/50) in medication group (both P < 0.05). According to the following-up after 6 menstrual periods, the recurrence rate was 9.1% (3/33), inferior to that of 35.3% (6/11) in medication group. The contents of PGF2alpha in peripheral blood of menstrual periods were all reduced after treatment in two groups (both P < 0.01).

CONCLUSIONThe curative effect of primary dysmenorrhea treated with eye acupuncture is favorable, and the lever of PGF2alpha in peripheral blood of menstrual periods is reduced.

Acupuncture Therapy ; Adolescent ; Adult ; Dinoprost ; blood ; Dysmenorrhea ; blood ; therapy ; Eye ; anatomy & histology ; Female ; Humans ; Young Adult

PURPOSE: To investigate whether prostaglandin F2alpha (PGF2alpha) affects on the production of nitric oxide (NO) in cultured ciliary muscle (CM) cells. METHODS: Following primary culture of CM cells from porcine eyes, the cells were exposed to PGF2alpha (PhXA85, latanoprost free acid) with and without pretreatments of NO synthase inhibitor (L-NAME, N omega- Nitro-L-arginine methyl ester) and cyclooxygenase inhibitors (indomethacin and dexamethasone) for 3 days. The cellular survivals were also evaluated in serum-deprived and hypoxic conditions induced by sodium cyanide. The cellular survival and nitrite production were assessed by MTT and Griess assay, respectively. RESULTS: PGF2alpha enhanced the production of NO significantly in cultured CM cells in a dose-dependent manner, while various inhibitors abolished this effect. PGF2alpha was not cytoprotective in serum-deprived and hypoxic conditions. CONCLUSIONS: The current results suggest that PGF2alpha potentiates NO production but is not cytoprotective in CM cells. This PGF2alpha-induced NO production in CM cells may be involved in the regulation of uveoscleral outflow.
Cyclooxygenase Inhibitors ; Dinoprost* ; Muscle Cells* ; Nitric Oxide Synthase ; Nitric Oxide* ; Sodium Cyanide

OBJECTIVE: Postpartum hemorrhage is most common cause of maternal mortality. Active management of third stage of labor minimizes the risk of postpartum hemorrhage. To compare the effect of methylergonovine and 15-methyl prostaglandin F2alpha (15-methyl PGF2alpha) in active management of third stage of labor. METHODS: A randomized open labelled parallel study with 50 women in normal labor, 25 in each group were included. The drugs methylergonovine (0.2 mg) intravenous and 15-methyl PGF2alpha (250 microg) intramuscular were administered at the time of delivery of anterior shoulder. Main outcomes measured were amount of blood loss during the first four hours of delivery and objective measurement of hemoglobin and hematocrit levels before delivery and third day postpartum. RESULTS: There was no statistically significant difference in the blood loss between the two groups at delivery (P = 0.130), at 1 hour of delivery (P = 0.453). The blood loss with 15-methyl PGF2alpha was significantly less as compared to that of blood loss with methylergonovine at four hours of delivery (P = 0.014) and the total, i.e., during first four hours, amount of blood loss was significantly less with 15-methyl PGF2alpha (P = 0.026). There was no statistically significant difference in the hemoglobin and hematocrit levels measured predelivery and postpartum third day between both the drugs. CONCLUSION: Both the drugs were effective in controlling the amount of blood loss during the third stage of labor, 15-methyl PGF2alpha being more efficacious.
Dinoprost ; Female ; Hematocrit ; Hemoglobins ; Humans ; Maternal Mortality ; Methylergonovine ; Postpartum Hemorrhage ; Postpartum Period ; Shoulder