1.Clinical Investigation on Shu Xin Yi Mai Capsule for Prevention of Restrenosis after Coronary Intervention Treatment in 22 Cases
Journal of Traditional Chinese Medicine 1993;0(05):-
Shu Xin Yi Mai Capsule combined with Western medical routine treatment was used for 22 successful cases of coronary intervention treatment ( Chinese - Western Medicine group) and 28 cases routinely treated with simple Western medicine were used as control (Western medicine group). Recurrence rales of angina pectoris before and after treatment were observed. Results indicated that the recurrence rate in the Chinese -Western medicine group was significantly lower than that in the Western medicine group GP
2.Effects of IGF-1 and oxLDL on expression of phosphatase PHLPP1 in vascular smooth muscular cells
Xingli WU ; Dingyou YANG ; Zhongsu YANG ; Deyin LI ; Huibin XU ; Shiwen WANG
Journal of Geriatric Cardiology 2009;6(4):237-240
Objective To investigate the effects of insulin-like growth factor-1 (IGF-1) and oxidized low density lipoprotein (oxLDL) on expression of phosphatase PHLPP1 in vascular smooth muscle cells (VSMCs).Methods Rabbit aortic VSMCs were cultured.VSMCs proliferation ability was determined by measuring cell number and mitochondrial dehydrogenase (MD) activity with MTT assay.Western blot was used to detect the protein expression of phosphatase PHLPP 1.Results IGF-1 (100μg/L) increased cell number and MD activity to 3.02 and 3.59 times of that in control group.oxLDL(50μg/ ml) elevated the above two parameters to 2.03 and 2.91 times respectively.Western blot showed that IGF-1 and oxLDL inhibited the expression of PHLPP 1 to 39.27% and 40.26% of the control group (P<0.01).Conclusion IGF-1 and oxLDL may enhance the proliferation of VSMCs by decreasing the expression of phosphatase PHLPP1 .