After more than a hundred years of development,hepatic surgery has gradually developed from a traditional rough model to a precise model in the 21st century.The era of precision liver surgery,and even precision medicine has come.Under the guidance of precise concept,the therapeutic effect of all liver diseases,especially liver malignant tumors,has been significantly improved,and the quality of life of patients has been significantly improved.Precise hepatectomy,precise radiofrequency ablation and precise transcatheter arterial chemoembolization are the three magic weapons of precise treatment in liver surgery.The precise concept will be the future development direction of medicine.This article reviews the research progress of precise treatment in liver surgery in order to further promote the concept of precise treatment in liver surgery.