Objective To analyze the vaccination status of National Immunization Program Vaccines (NIPV) and the occurrence of febrile seizures in children with febrile seizures (FS), and to provide a basis for improving the NIPV vaccination rate and preventing vaccine related disease outbreaks in these children. Methods A total of 416 cases of febrile seizure children who were admitted to the pediatric intensive care unit (PICU) of Guangxi Maternity and Child Health Hospital from January 2021 to January 2023 were selected as the case group. According to 1:1 matching，416 healthy children were randomly selected from the National Immunization Program Information System as the control group. The National Immunization Program Information System was used to inquire about the NIPV vaccination status of the two groups of study subjects. The children in the two groups were asked by phone whether they had febrile seizures after NIPV inoculation. Results The vaccination rates of NIPV (including basic and enhanced NIPV) were lower in the case group than those in the control group, and the differences were statistically significant (all P<0.05). Except for the boosted polio vaccine (PV) and adsorbed diphtheria (DT) vaccine case groups, the overdue vaccination rates were lower than those in the control group, and the overdue vaccination rates in all vaccine case groups were higher than those in the control group (all P<0.05). Conclusion There is no statistically significant difference in adverse reactions between children with a history of febrile seizures and healthy children after NIPV inoculation. The vaccination rate of children with a history of febrile seizures is generally low. All NIPV vaccination rates in children with febrile seizures are lower than those in healthy children, and the vaccines are not vaccinated on time.