OBJECTIVETo study the chemical constituents of the whole plant of Rhododendron concinnum.

METHODThe compounds were isolated and purified by chromatography on silica gel and polyamide. Their structures were identified on the basis of spectroscopic data (MS,1H-NMR and 13C-NMR) and chemical evidence.

RESULTFive dihydroflavones were isolated and identified as (2R)-farrerol-7-O-glucopyranoside (1), (2R,3R)-(-)-dihydroquercetin-3-O-beta-D-xylopyranoside(2), (2S,3S)-(-)-dihydroquercetin-3-O-beta-D-glucopyranoside(3), eriodictyol-7-O-beta-D-glucopyranoside (4) , (2R, 3R)-(+)-dihydroquercetin (5).

CONCLUSIONExcept compound 5, others were firstly isolated from the genus Rhododendron.

Antineoplastic Agents, Phytogenic ; pharmacology ; Cell Line, Tumor ; Cell Survival ; drug effects ; Chromatography, High Pressure Liquid ; methods ; Chromones ; chemistry ; Humans ; Inhibitory Concentration 50 ; Magnetic Resonance Spectroscopy ; Quercetin ; analogs & derivatives ; analysis ; pharmacology ; Rhododendron ; chemistry ; Silica Gel ; Silicon Dioxide ; analysis ; pharmacology

Objective This study aims to address the demand for high-quality medical talent cultivation in the new era.It focuses on the low integration of ideological and political education(IPE)with professional education,fragmented and insuffi-cient implementation of curriculum-based IPE,the failure to form a community for IPE,and the inadequacy of the IPE evaluation and supervision system.The goal is to construct an IPE system suitable for medical professionals.Methods Using literature re-search and empirical analysis,this study closely aligns with the actual construction of the IPE system for clinical medicine pro-grams at our institution.Under the competency model framework and guided by the Outcome-Based Education(OBE)philoso-phy,we adopt a student-centered approach.We explore the construction of the IPE system from six key aspects:theoretical rein-forcement,curriculum teaching,daily education,management and service,team building,and evaluation and supervision.Results This study successfully constructs a comprehensive IPE system that integrates ideological and political education,pro-fessional education,and vocational spirit education,addressing the content,process,subjects,and environment involved in pro-fessional talent cultivation.The system achieves a three-in-one integration of online and offline,in-class and extracurricular,and school and hospital settings,providing reform proposals and construction ideas for IPE in medical programs.Conclusion In the context of the new era,guided by the competency model framework and the OBE philosophy,comprehensive measures across six aspects can effectively build and improve the comprehensive IPE system for medical professionals.This is of significant impor-tance for cultivating high-quality medical talent.

AIM: To explore the effect of hydrogen sulfide on the senescence of human umbilical vein endothe -lial cells (HUVECs) induced by high glucose.METHODS: Senescence model was established by treating HUVECs with33 mmol/L glucose for 48 h.The parameters were detected to demonstrate the effect of hydrogen sulfide on senescence andthe mechanism involved was also investigated .RESULTS: In the cells treated with high glucose, the proliferation was attenuatedwith a higher number of senescence -associated β-galactosidase (SA-β-Gal) positive cells, and plasminogen activatorinhibitor 1 (PAI-1) protein expression, malondialdehyde (MDA) production and NF-κB p65 activity were increasedsignificantly, but the expression of superoxide dismutase 1 (SOD1) was decreased.However, the cell number and SOD1expression were increased, and the number of SA-β-Gal positive cells, PAI-1 protein expression, MDA production and theactivity of NF-κB p65 were decreased after sodium hydrosulfide (100 and 200 μmol/L) treatment.CONCLUSION: Exogenoushydrogen sulfide prevents HUVECs against high glucose -induced senescence by suppressing oxidative stress and NF -κB p65 activity.

A motion unit for sucking robot with a stable motion, convenient operation and process simulation is introduced. The key parameters and process data of the sucking operation were obtained from the clinical work, which provided the basis for the design of the sucking robot motion unit. According to the points of sucking action, robotic thumb, forefinger and metacarpophalangeal joints were used to grip the suction tube, and the servo and arm structure were used to simulate the motion of the wrist and elbow to complete the rotation and push of the sputum suction tube. The feasibility is verified through the advanced sputum suction training model. The movement unit is stable in movement, and can smoothly complete the clamping, feeding, back off protection and rotating tube removal of the sputum suction tube, so as to achieve effective sputum suction.
Catheterization ; Intubation, Intratracheal ; Robotics ; Suction

A biliary contrast agents pushing device, including a syringe pushing system and a remote controller is introduced. The syringe pushing system comprises an injector card slot, a support platform and an injection bolus fader. A 20 mL syringe can be fitted on the syringe pushing system and kept with the ground about 30 degree. This system can perform air bubble pumping back and contrast agents bolus injection as well as speed adjustment. Remote controller is an infrared remote control which can start and stop the syringe pushing system. With this device, the remote controlled cholangiography technology can be achieved, which can not only protect doctors from X-ray radiation but also improve the traditional T-tube cholangiography and the contrast effect, reduce postoperative complications in patients as well. The application of this device will improve the current diagnosis and treatment system, the device will benefit the majority of doctors and patients.
Contrast Media ; administration & dosage ; Humans ; Injections ; Postoperative Complications ; Syringes

Magnetic anchoring technology provides a new development opportunity for current minimally invasive surgery. The magnetic anchoring abdominal video system based on this technology can effectively improve the operability and minimally invasiveness of single-port laparoscopic surgery. The development history of magnetically anchored abdominal video system was reviewed, and the design features and deficiencies of various types of magnetically anchored video devices were compared and analyzed. The evolution characteristics of the magnetic anchored video system are explained from minimally invasive and intelligent perspectives, and the challenges and opportunities of magnetic anchored video system are summarized and prospected.
Abdomen ; Laparoscopy ; Magnetics ; Minimally Invasive Surgical Procedures