Colorectal stem cells have many bio-markers, including Lgr5 which expression is associated with THE stage of disease , also regulating the cell cycle , anothers is +4 stem cell , which is associated with tumor heteroge-neity, also expressed Bmi1, arresting cell cycle.Besides there is Msi1.Many studies show that those markers are highly expressed in colorectal cancer , which activate Notch and Wnt signaling pathway , and can promote the pro-gress of tumor .

Antiviral Agents ; therapeutic use ; Female ; Hepatitis B, Chronic ; drug therapy ; Humans ; Pregnancy ; Pregnancy Complications, Infectious ; drug therapy ; virology

Objective To investigate the mid-term efficacy of retrievable stent filter placement for the treatment of Budd-Chiari syndrome (BCS) complicated with inferior vena cava (IVC) thrombosis. Methods Eight patients of BCS complicated with IVC thrombosis were enrolled in this study. IVC thrombosis included segmental occlusion (n = 2) and membranous occlusion (n = 6). In all patients, the IVC was re-canalized by using blunt wire after anticoagulation and thrombolytic therapy, then, the re-canalized site was expanded with small balloon, which was followed by the placement of retrievable stent filter, and, finally, IVC size was dilated with larger balloon. Anticoagulation and thrombolytic therapy was given after the procedure. And all the retrievable stent filters were withdrawn from the IVC through internal jugular vein when the thrombus in IVC was dissolved. In patients with segmental occlusion of IVC, in addition to the placement of retrievable stent filter a "Z" type vessel stent was also placed during the same interventional session. Follow-up examination with color Doppler sonography was conducted in all patients. Results Technical success was achieved in all 8 patients without pulmonary infarction or other complications both during and after the operation. Immediately after the thrombus completely disappeared, the retrievable stent filter was successfully taken out in all patients. During a following-up period of 3-12 months, color Doppler sonographs showed that the IVC remained patent in 6 patients and had a recurrence of stenosis in 2 patients. Conclusion Placement of retrievable stent filter is a safe and effective treatment for BCS complicated with IVC thrombosis.

Objective:To investigate the influence of auxiliary application of Xuesaitong injection on blood coagulation indices and thromboembolic complications in the patients after finger replantation. Methods:Totally 64 patients with finger replantation were cho-sen from March 2012 to March 2014 in our hospital and randomly divided into the control group (32 patients) treated with low molecu-lar weight heparin and Xuesaitong group (32 patients) treated with Xuesaitong injection additionally. The clinical curative effect, sur-vival time of finger replantation, the levels of blood coagulation indices before and after the operation and the incidence of thrombotic complications in both groups were compared. Results: The clinical curative effect of the control group and Xuesaitong group was 68. 75% and 93. 75, respectively, and that of Xuesaitong group was significantly better than that of the control group (P<0. 05). The survival time of finger replantation of the control group and Xuesaitong group was (9. 44 ± 1. 56)d and (6. 72 ± 2. 28)d, respectively, and that of Xuesaitong group was significantly better than that of the control group (P<0. 05). The levels of blood coagulation indices on 1d, 4d and 7d after the operation in Xuesaitong group was significantly better than those in the control group and those before the treatment(P<0. 05). After the treatment, gastrointestinal hormone levels in Xuesaitong group was significantly better than those in the control group(P<0. 05). The incidence of thrombotic complications in the Xuesaitong group was significantly better than that of the control group(P<0. 05). There was no significant difference in the adverse effects between the two groups (P>0. 05). Conclusion:Auxiliary application of Xuesaitong injection in the patients after finger replantation can efficiently speed up the replantation survival process and improve blood coagulation indices after the operation, which is helpful to reducing the risk of thrombotic complications.

This article summarizes 32 cases of the SCI patients suffered from bladder stones.Respects relating to causes,characteristic,diagnosis,treatment and prevention of bladder stones after SCI are discussed in the article.In order to decrease or avoid complication of indwelling urethral catheter,the patients with neuropathic bladder dysfunction are treated by intermittent catheterization.If it is necessary for SCI patients to indwell urethral catheter,we must strengthen management of the catheter and renew a catheter in time(once a week).

Accidents, Occupational ; prevention & control ; statistics & numerical data ; Adult ; China ; epidemiology ; Female ; Humans ; Male ; Middle Aged ; Poisoning ; epidemiology ; prevention & control

Anatomical hepatic segmentectomy is the treatment of choice for hepatolithiasis. However, in consideration of the volume of residual liver and the liver function, anatomical polysegmentectomy of the bilateral lobes for hepatolithiasis is restricted. Protection of the portal pedicles to the segments preserved and avoidance of ischemia/reperfusion injury to the residual liver parenchyma are critical steps during the operation.A female patient with hepatolithiasis and had a surgical history of choledocholithiasis removal and T-tube drainage received ana tomic polysegmentectomy with segments Ⅰ and Ⅳ preservation at the General Hospital of Kunming Medical College. During the operation, Portal pedicles to the segments Ⅰ , Ⅱ, right lobe,and segments Ⅱ and Ⅲ were isolated prior to liver parenchyma transection. Portal pedicles to segments Ⅰ and Ⅳ were protected under direct visualization. Hepatoduodenal ligament occlusion was not applied during liver parenchyma transaction. Segments Ⅱ- Ⅲ and Ⅴ-Ⅷ were anatomically resected, and segments Ⅰ ,Ⅳ were preserved with satisfactory vascularization. The patient recovered uneventfully and was discharged 14 days after the operation.

Seven compounds were isolated from the alcohol extract of leaves of Ipomoea batafas Lam,by column chromatography on silica gel. They were identified by physical and chemical methods as quercetin-3-glucoside (Ⅰ), kaempferol-4＇, 7-dimethyl ether(Ⅱ), ombuin (Ⅲ),quercetin (Ⅳ), quercetin-3＇, 4＇, 7-trimethyl ether(Ⅴ), ?-sitosterol (Ⅵ) and sucrose (Ⅶ).All of them were isolated from this plant for the first time.

Musashi1 (Msi1) is an evolutionary conservative RNA-binding protein (RBP),and it is a stem marker in a variety of organizations,including intestinal,neural system.Msi1 maintains the balance between self-renewal and differentiation.Recently,many researchers report that Msi1 is overexpressed in many types of tumors,especially in colorectal neoplasms,participating in the regulation of cell cycle,proliferation,apoptosis and so on.Msi1 becomes a key regulator of many cancers,which is expected to turn into a new target for cancer therapy.

Objective To investigate the value of CT signs in combination with clinical materials of papillary thyroid carcinoma (PTC) to predict the central lymph node metastasis (CLNM).Methods This article reviewed the CT signs and clinical materials of 366 patients with surgically and pathologically verified PTC.The single factor and multi-factor logistic regression analyses were performed on the relation of tumor position,thyroid marginal contact,calcification,plain scan border,border after enhancement,diameter,age and sex with CLNM.Results Among the 366 patients with PTC,the number of patients with positive CLNM and negative CLNM was 155 and 211 respectively.The single factor and multi-factor logistic regression analysis indicated that the thyroid marginal contact,diameter,age and sex were related with CLNM,and the more common patients diagnosed with CLNM had the following features:thyroid marginal contact,a diameter ＞1.0 cm,age ＜45 years and males (P＜ 0.05).Among the single risk factors,the tumor position,calcification,plain scan border and border after enhancement were unrelated with CLNM (P＞0.05).Conclusion The thyroid margin contact,diameter＞l.0 cm,age＜45 years and males are independent risk factors in diagnosis of positive CLNM.