Objective To analyze the relative factors of bone marrow suppression after chemotherapy with different-dose carboplatin and paclitaxel (TC) on the patients with ovarian cancer.Methods Sixty-two patients with ovarian cancer admitted in Beijing Obstetrics and Gynecology Hospital from January 2002 to December 2007, using TC regimen ,a total of 196 cycles of chemotherapy ,were divided into two groups by the doses of carboplatin [area under concentration-time curve(AUC) 4 -6 for low-dose,AUC >6 -7 for hight-dose, the carboplatin dose calculated with AUC] or by the doses of paclitaxel (135 -< 150 mg/m2 low-dose,150 - 175 mg/m2 hight-dose). After each TC cycle, the routine blood was test to determine the graduation of the marrow suppression, and then the correlation factors were analyzed with logistic regression. Results (1) The occurrence rate of bone marrow suppression:there were 159 cycles (81.1%) grade 0 - Ⅱ bone marrow suppression, while 37 cycles (18.9%) of grade Ⅲ - Ⅳ. (2) Factors related to bone marrow suppression:the results shown that there were not related to bone marrow suppression,which incluced cellular differentiation, tumor type, height, weight and paclitaxel dose(P>0.05). While,the different cycle, age, the later stages of tumor, serum creatinine concentration, endogenous creatinine clearance rate, AUC values were the relative factors of bone marrow suppression(P =0.000,0.000,0.018,0.033,0.001,0.000). Seven variables were conducted into the logistic regression and the results shown that the different cycles, the age, AUC grades were independent risk factors (P = 0.030,0.043,0.009).(3) When low-dose of paclitaxel was given, the occurrence of bone marrow suppression was related to the carboplatin dose AUC. The higher AUC values for carbopaltin were chosen, the higher of severe bone marrow suppression would happen. (4/14 vs 0,P=0.015). When the dose of high grade of paclitaxel was given, the occurrence of bone marrow suppression in cases with hight-dose carboplatin was statistically significant than that in cases treated with low-dose carboplatin [45.7%(16/35) vs 13.7% (17/124), P=0.000]. Conclusions The independent risk factors of myelosuppression after chemotherapy with TC regime on the patients with ovarian cancer including the cycles, age and AUC values. The carboplatin dose calculating with AUC is related to the occurrence of bone marrow suppression, the higher AUC values for carbopaltin would chosen,the higher of severe bone marrow suppression would be happen.

ObjectiveTo explore the ability of inhibition resistibility of multiple displacement amplification (MDA)in samples with inhibitors. To explain the application and value of MDA in forensic medicine by comparing with using magnetic beads methods(MBM)to purify sample.MethodsDifferent concentra-tions of hemoglobin and humid acid(HA)mixed with DNA samples and then divided the samples into MDA group, MBM group and control group.D3S1358locus was amplified and detected by polyacry-lamide gel electrophoresis detection system and AmpF?STR? IdentifilerTM Plus Kit-capillary electrophore-sis detection system.ResultsWhen hemoglobin concentrations exceed 1 ng/μL or HA concentrations ex-ceed 0.1 ng/μL, amplification products could not be obtained by single-locus system in control group. When hemoglobin concentration exceeds 100 ng/μL or HA concentrations exceed 1 ng/μL, the samples could not be amplified by MBM. Inhibitors in different concentrations were amplified successfully in MDA group without any influence from inhibitors.ConclusionMDA has the capability to remove the inhibi-tion of hemoglobin and HA, which is better than MBM and has a certain value in forensic practices.

Objective To observe the efficacy and side effect of olanzapine combined with tropisetron, dexamethasone for the pre-vention of highly emetogenic chemotherapy-induced nausea and vomiting ( CINV) . Methods A total of 78 patients with highly emetogen-ic single day chemotherapy were randomly divided into two groups:trial group ( olanzapine combined with tropisetron, dexamethasone n=40) and control group (Tropisetron Combined with Dexamethasone n=38). The control of acute CINV, delayed CINV and adverse reac-tions were observed. Results The control rates of acute vomiting in trial group and control group were 87. 5% vs 81. 6%, 65. 0% vs 57. 9% in acute nausea, 75. 0% vs 52. 6% in delayed vomiting, 32. 5% vs 13. 2% in delayed nausea. The trial group was better than the control group in delayed vomiting and delayed nausea which there was difference between them (P < 0. 05). There was no statistical differ-ence between the two groups in the incidence of adverse reactions (P>0. 05). Conclusion Olanzapine combined with tropisetron, dexa-methasone for the prevention was significantly better than tropisetron combined with dexamethasone in the control of delayed CINV in pa-tients received highly emetogenic chemotherapy.

Child ; Evidence-Based Medicine ; Glomerulonephritis, IGA ; diagnosis ; therapy ; Guidelines as Topic ; Humans

Female ; Humans ; Melanosis ; Middle Aged ; Occupational Diseases

Child ; China ; Humans ; Pediatrics ; Periodicals as Topic ; standards ; statistics & numerical data ; Publishing ; standards ; statistics & numerical data ; Quality Control

Child ; Child, Preschool ; China ; epidemiology ; Evidence-Based Medicine ; Humans ; Kidney Diseases ; diagnosis ; epidemiology ; therapy ; Practice Guidelines as Topic

Bartter Syndrome ; complications ; Diarrhea ; etiology ; Female ; Humans ; Infant ; Male ; Syndrome

Objective To investigcte the effects of elderly pregnancy complicated by hypeaensive disorder on the pregnant outcome.Methods The analysis on the ultimate outcomes of pregnancy with HDCP and their neo nates is conducted.among which 51 cases with the pregnancy at the age of 35 or above were chosen as the observation group,while 143 cases whose ages are below 35 were chosen as the control group and their 217 neonates.The process of two groups of pregnancy complications:The rate of heart failure,abnormal liver function,kidney damage,HELLP syndrome,premature,placenta abruption,severe preeclampsia and eclampsia.The rate of fetal distress,neonatal as phyxia,perinatal mortality rate,FGR were observed.Results The rate of kidney damage,abnormal liver function, HELLP syndrome or premature in the observation group is remarkably higher than that in the contrl group(P＜ 0.05).There is no significant difference between the two groups on the rate of severe preeclampsia and eclampsia, heart failure,placenta abruption(P＞0.05).The rate of FGR,fetal distress,neonatal asphyxia,perinatal mortality rate is signicartly higher in the observation group than that in the control group(P＜0.05).Conclusion Elderly pregnancy complicated by HDCP is harmful for pregnant women and neonatal.It is necessary to reinforce the prevention measures and clinical treatment.

Objective To explore the clinical value of the cervical loop electrosurgical excision procedure (LEEP) for cervical CIN M. Methods The pelvic examination in the liquid-based cytology(TCT) ,human papilloma virus(HPV) ,colposcopy and cervical biopsies initially diagnosed as more patients with CIN IE LEEP surgery,removal of diseased tissue sent pathology, operation time, operative blood loss and surgical effect were observed. Results LEEP surgical treatment of cervical CIN Ⅲ was an effective method,by LEEP surgical pathology specimens of the second to prevent over-treatment,for some with conservation of the uterus and fertility function for possible,and the right to avoid the misdiagnosis of cervical cancer has important significance. Conclusion Cytology-colposcopy-LEEP surgery treatment was effective to block the emergence of the incidence of cervical cancer.