1.Non-skeletal actions of vitamin D
Chinese Journal of Clinical Nutrition 2009;17(4):246-250
non-skeletal actions,including immunoregulation,anti-tumor effect,and protecting from central nervous system diseases and metabelie syndrome.
2.Effect of ultraviolet rays and mechanism of injury to eyes
Chinese Journal of Radiological Medicine and Protection 2016;36(2):149-153
With continued ozone deletion and increased ultraviolet application,ultraviolet (UV) induced eye injury receives more attention,especially for astronauts,residents on high elevation plateaus and other people exposed to intense beams of UV.Continuous exposure to UV can lead to damage of conjunctiva,cornea,crystalline lens and retina,which are correlated with conjunctivitis,keratitis,ocular tumor,climatic droplet keratopathy,and pterygium.This paper focuses on the effect of UV on eyes,with a systematic elaboration of UV-induced eye injury.
3.Efficacy and safety of dipeptide base peptidase 4 inhibitors combined with metformin combination therapy in type 2 diabetes
Ran DING ; Guocong DING ; Rihong CAI
Chinese Journal of Biochemical Pharmaceutics 2016;36(12):154-156,159
Objective To evaluate the clinical efficacy and safety of dipeptide base peptidase 4 ( DPP-4 ) inhibitors alone or combined with metformin in curing type 2 diabetes mellitus (T2DM).Methods 90 patients diagnosed with type 2 diabetes in Tangshan Fengrun District Hospital and Tangshan Checheng Hospital were selected and randomly divided into therapy group ( DPP4 inhibitor ) , control group ( metformin ) and combination therapy group with 30 cases in each group.And treatment for three months, the free blood glucose (FPG), 2-hour postprandial blood glucose (2hPG), glycated hemoglobin (HbA1c) levels and other indicators were compare before and after treatment, and the rates of hypoglycaemia and adverse events during treatment were monitored and counted.Results After 3 months of treatment, the free blood glucose, 2-hour postprandial blood glucose, LDL-C and HbA1c levels were significantly decreased, the difference was statistically significant (P<0.05) while the combination therapy group compared with the the therapy group and control group with better results.The incidence of side-effect in the combination therapy group is significantly lower than the therapy group and control group, the difference was statistically significant (P<0.05).It is no cases of hypoglycemia occurs in the combination therapy group, and had a smaller effect on BMI.Conclusion DPP-4 inhibitors combined with metformin in patients with type 2 diabetes has better efficacy and safety.
4.Effect of Parallel Scalp Acupuncture Therapy on Hemodynamic Function of Cerebral Circulation in Post-stroke Patients
Li LI ; Jianqiu GONG ; Guanghong DING ; Deheng CAI ; Yi CAI
Journal of Acupuncture and Tuina Science 2008;6(5):309-311
Objective: To evaluate the effect of parallel scalp acupuncture therapy on hemodynamic function of cerebral circulation in post-stroke patients. Methods: Twenty post-stroke patients were taken as our objects. The cerebral circulation indices before and after parallel acupuncture therapy, were detected with KF-3000 Brain Circulation Analyze, to compare the change of hemodynamics indexes before and after parallel scalp acupuncture. Results: After the therapy, minimum and mean blood velocity of carotid artery (Vmin and Vmean) increased significantly (P<0.001); peripheral resistance (Rc) decreased significantly (P<0.001). And the other indices had no significant differences. Conclusion: Parallel Scalp Acupuncture can improve the state of cerebrovascular autoregulation, raise the velocity of blood, decrease the peripheral resistance, and increase the steady energy, total energy and the ratio of kinetic energy to total energy, decrease the ratio of oscillatory kinetic energy to total kinetic energy.
6.Research advances in relationship between microelements and metabolic syndrome in children
Huiping DING ; Meiqin CAI ; Chunhua JIANG
Chinese Journal of Clinical Nutrition 2009;17(6):378-382
The prevalence of the metabolic syndrome (MS) in children has increased over the last decade.Research shows that the microelements including zinc,copper,iron,chromium,and selenium are relevant with the development of childhood MS.This article summarizes the recent advances in the relationship between microele-ments and MS.
7.Alteration of the plasma concentration of all-trans retinoic acid(ATRA) in type 1 diabetes mellitus
Li DING ; Dehong CAI ; Di WANG
Chinese Journal of Diabetes 2006;14(1):50-51
To study the abnormality of the plasma concentration of ATRA in T1DM patients.T1DM patients(n=26),T2DM patients(n=33) and healthy people(n=30) were enrolled.The plasma concentration of ATRA was determined by HPLC.Compared with T2DM patients and healthy people,the concentration of ATRA increased significantly in T1DM patients.
8.The effect of the recombinant plasmid pcDNA3.1/C-sis on FHF of rats
Pengcheng CAI ; Wenfeng YUAN ; Hao DING
Chongqing Medicine 2017;46(19):2604-2607,2611
Objective To explore the effect of the recombinant plasmid pcDNA3.1/C-sis on fulminant hepatic failure (FHF) in rats.Methods 48 h after recombinant plasmid pcDNA3.1/C-sis being imported into rat liver by using the method of fluid mechanics,FHF in rats was induced by endotoxin (LPS)+D-galactosamine (D-GaIN).With fluorescence quantitative PCR and Western blotting,C-sis expression was tested.The apoptosis of rat liver was detected by using HE staining and measuring Caspase-3 activity.The expression changes of Bcl-2 and Bax were examined through using Western blotting.The mortality rate of rats was calculated during 24 h observation period.Resnlts Compared with the normal control group and FHF+ empty plasmid group,C-sis mRNA and protein expression levels were increased significantly in the FHF+C-sis plasmid group,there were statistically significant differences (P<0.01).Compared with the normal control group,the apoptotic hepatocytes were increased in the FHF + Ringer's solution injection group and FHF+ empty plasmid group;compared with FHF+ empty plasmid group,the apoptotic hepatocytes in the FHF+C-sis plasmid group were decreased.Compared with the normal control group,Caspase-3 expression level was increased in the FHF+ Ringer's solution injection group (P<0.01);compared with the FHF+ empty plasmid group,Caspase-3 expression level in the FHF+C-sis plasmid group was decreased (P<0.05).Compared with the normal control group,Bcl-2 expression level was decreased significantly (P<0.01),and Bax expression level was increased significantly (P<0.01) in the FHF+Ringer's solution injection group;compared with the FHF+ empty plasmid group,the Bcl-2 expression level was increased (P<0.05),and Bax expression was decreased (P<0.05)in the FHF+C-sis plasmid group.During the 24 h observation period,all rats in the normal control group were alive;the mortality rates of the FHF+ Ringer's solution injection group and FHF+ empty plasmid group were 70.0% and 80.0% respectively,while that of the FHF+C-sis plasmid group was only 20.0%.Conclusion C-sis gene could inhibit FHF in rats induced by LPS+D-GalN.
9.Clinical Study on the Treatment of Adriamycin-induced Cardiotoxicity with the Method of Nourishing Yin
International Journal of Traditional Chinese Medicine 2009;31(5):401-403
Objective To investigate the preventive effect of treating cardiotoxicity induced by adriamycin (ADM) with the method of nourishing yin. Methods 90 cancer patients underwent adriamycin therapy were randomly recruited intoa treatment group (45 cases) and a control group (45 cases). The treatment group was treated with Wushen decoction, while the control group was treated with antioxidant drugs. The changes of ECG, blood SOD, GSH-Px, MDA content etc were observed after one course of four weeks' treatment. Results The incidence of cardiactoxicity was 15.56% in the treatment group and 40.00% in the control group, showing significant difference ( U=2.02, P<0.05 ) ; the incidence of ECG abnormalities was 13.33% in the treatment group and 37.78%, in the control group, showing significant difference (U= 2.18, P< 0.05 ) : the effective rate was 82.22% in the treatment group and 62.22% in the control group, showing significant difference ( U=2.18, P <0.05) ; and SOD, GSH-Px, MDA content at the 1, 7, 14, and 28days between the two groups also demonstrated significant differences (P<0.05) . Conclusion The method of nourishing yin has excellent attenuation to adriamycin-induced cardiotoxicity, besides it enhances therapeutic effects of chemotherapy.
10.The study of the induction of thymocytes apoptotisis by superantigen SEB in vitro
Li DING ; Dehong CAI ; Dingwen JIANG
Chinese Journal of Immunology 1985;0(02):-
Objective:To investigate whether superantigen SEB,with the assistance of APCs,could induce apoptosis of thymocytes in vitro,and to study the mechanism involved.Methods:SEB was given to thymocytes which were cultured together with APCs.Apoptosis was detected by DNA electrophoresis and DNA fragmentation assay.Expressions of Fas and FasL were detected by flow cytometry.Results:The thymocytes treated with SEB had the characters of apoptosis,and the apoptotic rate and expressions of Fas and FasL was significantly increased compared with control.Conclusion:SEB,together with APCs,can induce apoptosis of thymocytes in vitro,high expressions of Fas and FasL on thymocyte may participate in the mediation of apoptosis.This may provide a method to study the negative selection of thymocytes.