1.Effect of ultraviolet rays and mechanism of injury to eyes
Chinese Journal of Radiological Medicine and Protection 2016;36(2):149-153
With continued ozone deletion and increased ultraviolet application,ultraviolet (UV) induced eye injury receives more attention,especially for astronauts,residents on high elevation plateaus and other people exposed to intense beams of UV.Continuous exposure to UV can lead to damage of conjunctiva,cornea,crystalline lens and retina,which are correlated with conjunctivitis,keratitis,ocular tumor,climatic droplet keratopathy,and pterygium.This paper focuses on the effect of UV on eyes,with a systematic elaboration of UV-induced eye injury.
2.Non-skeletal actions of vitamin D
Chinese Journal of Clinical Nutrition 2009;17(4):246-250
non-skeletal actions,including immunoregulation,anti-tumor effect,and protecting from central nervous system diseases and metabelie syndrome.
3.Efficacy and safety of dipeptide base peptidase 4 inhibitors combined with metformin combination therapy in type 2 diabetes
Ran DING ; Guocong DING ; Rihong CAI
Chinese Journal of Biochemical Pharmaceutics 2016;36(12):154-156,159
Objective To evaluate the clinical efficacy and safety of dipeptide base peptidase 4 ( DPP-4 ) inhibitors alone or combined with metformin in curing type 2 diabetes mellitus (T2DM).Methods 90 patients diagnosed with type 2 diabetes in Tangshan Fengrun District Hospital and Tangshan Checheng Hospital were selected and randomly divided into therapy group ( DPP4 inhibitor ) , control group ( metformin ) and combination therapy group with 30 cases in each group.And treatment for three months, the free blood glucose (FPG), 2-hour postprandial blood glucose (2hPG), glycated hemoglobin (HbA1c) levels and other indicators were compare before and after treatment, and the rates of hypoglycaemia and adverse events during treatment were monitored and counted.Results After 3 months of treatment, the free blood glucose, 2-hour postprandial blood glucose, LDL-C and HbA1c levels were significantly decreased, the difference was statistically significant (P<0.05) while the combination therapy group compared with the the therapy group and control group with better results.The incidence of side-effect in the combination therapy group is significantly lower than the therapy group and control group, the difference was statistically significant (P<0.05).It is no cases of hypoglycemia occurs in the combination therapy group, and had a smaller effect on BMI.Conclusion DPP-4 inhibitors combined with metformin in patients with type 2 diabetes has better efficacy and safety.
4.Effect of Parallel Scalp Acupuncture Therapy on Hemodynamic Function of Cerebral Circulation in Post-stroke Patients
Li LI ; Jianqiu GONG ; Guanghong DING ; Deheng CAI ; Yi CAI
Journal of Acupuncture and Tuina Science 2008;6(5):309-311
Objective: To evaluate the effect of parallel scalp acupuncture therapy on hemodynamic function of cerebral circulation in post-stroke patients. Methods: Twenty post-stroke patients were taken as our objects. The cerebral circulation indices before and after parallel acupuncture therapy, were detected with KF-3000 Brain Circulation Analyze, to compare the change of hemodynamics indexes before and after parallel scalp acupuncture. Results: After the therapy, minimum and mean blood velocity of carotid artery (Vmin and Vmean) increased significantly (P<0.001); peripheral resistance (Rc) decreased significantly (P<0.001). And the other indices had no significant differences. Conclusion: Parallel Scalp Acupuncture can improve the state of cerebrovascular autoregulation, raise the velocity of blood, decrease the peripheral resistance, and increase the steady energy, total energy and the ratio of kinetic energy to total energy, decrease the ratio of oscillatory kinetic energy to total kinetic energy.
5.Effect of K_(La)?on Ginseng (Panax ginseng) Cell Culture
Jiayi DING ; Jun CAI ; Chongde ZHAO
Chinese Traditional and Herbal Drugs 1994;0(01):-
Cell culture of Ginseng (Panax ginseng ) was conducted under different K_(La)?,with other conditions kept coustant. Results showed that the best range of K_(La)? for Gingseng cell cultu re was 18~27h-1.
6.Determination of Icariin in Chuanlong Guci Pian by HPLC
Yongzhi DING ; Xiaofeng LI ; Junan CAI
Chinese Journal of Information on Traditional Chinese Medicine 2006;0(03):-
Objective To establish the method for detemining the content of Icariin in Chuanlong Guci Pian by HPLC. Methods Diamonsil ODS1 C18 Column was used with acetonitrile-water (27∶73) as the mobile phase, detection wavelength as 270 nm, and flow rate was 1.0 mL/min. Results The calibration curve was linear at the range of 0.125~1.00 ?g for Icariin and linear equation was Y=81 601X+10 356, r 2=0.999 7. The average recovery was 99.12% and RSD was 0.65% (n=6). Conclusion This method was simple, accurate and proper, and the reduplication of the result was good, which provides scientific quantitative analysis of Icariin in Chuanlong Guci Pian.
7.Optimization of the Processing Technology for Fructus Corni by Orthogonal Test
Zongliang YU ; Baochang CAI ; Xia DING
Traditional Chinese Drug Research & Clinical Pharmacology 1993;0(02):-
Objective To optimize the technology for processing Fructus Corni steamed with alcohol. Methods With the yield of polysaccharide from Fructus Cornias as the indicators,three factors(of wine volume,moistening time, steaming time)were optimized by orthogonal test . Results The optimal processing technology for processing Fructus Corni is as follows: the wine volume for 25 %,moistening for 2 h, steaming for 4 h. Conclusion The optimal processing technology for processing Fructus Corni is reasonable.
8.The effect of comprehensive intervention on the quality of life of esophageal cancer patients treated with radiotherapy
Jieyun DING ; Xiaojuan CAI ; Mei CHEN
Chinese Journal of Clinical Nutrition 2016;24(4):230-235
Objective To discuss the effect of comprehensive intervention on the quality of life of esophageal cancer patients receiving radiotherapy.Methods 100 patients with esophageal carcinoma treated with radiotherapy for the first timewere selected between October 2012 and December 2014 in Nantong Tumor Hospital in Jiangsu Province and randomly divided into control group and observation group (n =50 in each group) with a random number table.In the control group,routine dietary instruction,fluid infusion support and symptomatic intervention were used;comprehensive intervention was added in the observation group.Scores of core quality of life questionnaire (QLQ-C30) and nutritional indexesbefore and after radiotherapy in the two groups were compared.Results There were no statistically significant differences in QLQ-C30 scores and nutritional indexes between the two groups before radiotherapy (all P>0.05).After radiotherapy,the physical [(75.6 ±13.1) vs.(63.8 ± 12.4)] and emotional function [(61.9 ± 14.3) vs.(52.5 ± 13.7)],fatigue [(36.6 ± 13.2) vs.(45.8±15.0)],pain [(34.8±16.1) vs.(44.3±17.0)],insomnia [(49.2±15.7) vs.(57.2±14.3)],loss of appetite [(50.2 ± 16.2) vs.(59.0 ± 15.8)],nausea and vomiting [(21.5 ± 10.3) vs.(29.9 ±11.3)],general health status [(68.8 ± 13.4) vs.(58.2 ± 12.8)] inthe observation group were significantly better than in the control group (all P <0.05).Innutritional status,body weight [(59.3 ± 8.5) kg vs.(54.4 ± 7.3) kg],body mass index [(21.9 ±2.1) kg/m2 vs.(18.4 ±2.8) kg/m2],hemoglobin [(125.9 ± 8.9) g/Lvs.(107.3±9.5) g/L],albumin [(35.1±6.9) g/Lvs.(29.0±5.3) g/L],and prealbumin [(213.54 ±37.47) mg/L vs.(174.56 ±36.26) mg/L] in the observation group were all higher than thosein the control group after radiotherapy (all P < 0.01).Conclusion Comprehensive intervention for esophageal cancer patients receiving radiotherapymay improve nutritional status,reduce esophagitis,thirsty,fatigue,loss of appetite and other symptoms,improve the quality of life,ensure the completion of radiotherapy.
9.The association of platelet-derived endothelial cell growth factor with bladder transitional cell carcinoma
Yichun ZHENG ; Wei DING ; Songliang CAI
Chinese Journal of Urology 2001;0(11):-
Objective To investigate the correlation of clinical and pathological characteristics of bladder transitional cell carcinoma(BTCC) with platelet-derived endothelial cell growth factor (PD-ECGF). Methods Expression of PD-ECGF,VEGF and MVD were examined in the specimens of 52 cases of BTCC by Envision immunohistochemical staining.All the 52 cases were followed up via interview for a period of 5 years. Results Of the 52 cases 50 provided complete relevant data.The 5-year postoperative tumor-free survival rate was 42.9%(21/49) and overall survival rate was 78.0%(39/50).The positive expression rate of PD-ECGF in G 1 tumors was 17.6%(3/17);in G 2,59.3%(16/27) and in G 3,87.5%(7/8)(P
10.The study of the induction of thymocytes apoptotisis by superantigen SEB in vitro
Li DING ; Dehong CAI ; Dingwen JIANG
Chinese Journal of Immunology 1985;0(02):-
Objective:To investigate whether superantigen SEB,with the assistance of APCs,could induce apoptosis of thymocytes in vitro,and to study the mechanism involved.Methods:SEB was given to thymocytes which were cultured together with APCs.Apoptosis was detected by DNA electrophoresis and DNA fragmentation assay.Expressions of Fas and FasL were detected by flow cytometry.Results:The thymocytes treated with SEB had the characters of apoptosis,and the apoptotic rate and expressions of Fas and FasL was significantly increased compared with control.Conclusion:SEB,together with APCs,can induce apoptosis of thymocytes in vitro,high expressions of Fas and FasL on thymocyte may participate in the mediation of apoptosis.This may provide a method to study the negative selection of thymocytes.