Periodontal ligament may have independent response to orthodontic stimulation and thus initiate alveolar bone osteogenesis and osteoclasts. Orthodontic-induced alveolar bone remodeling has no bone loss,while inflammation can lead to alveolar bone loss,suggesting that force signal and inflammatory factors may induce the differentiation of undifferentiated cells in the periodontal ligament via different pathways. The strength of the force and the nature of the force (basal tension and fluid shear force) may affect the differentiation of periodontal ligament cells,and may produce antagonistic or synergistic effect with the inflammatory factors through complex autocrine and paracrine regulation,resulting in local bone reconstruction,which is manifested as bone deposition and bone absorption. Studies have shown that Wnt signaling is an important regulatory pathway for osteoblast differentiation. Inflammatory factors can block the differentiation of stem cells into osteoblasts. The Wnt pathway is closely related to the effects of force and inflammatory factors on the differentiation of periodontal ligament cells.

Adenine ; analogs & derivatives ; therapeutic use ; Animals ; Antiviral Agents ; therapeutic use ; Combined Modality Therapy ; Genetic Therapy ; Hepatitis B Antigens ; immunology ; Hepatitis B Vaccines ; therapeutic use ; Hepatitis B, Chronic ; therapy ; Humans ; Interferon-alpha ; administration & dosage ; Lamivudine ; therapeutic use ; Organophosphonates ; therapeutic use ; Recombinant Proteins

Humans ; Liver Failure

Hepatolenticular Degeneration ; Humans ; Nervous System Diseases

Antiviral Agents ; therapeutic use ; Hepatitis B ; drug therapy ; Hepatitis C ; drug therapy ; Humans ; Interferons ; therapeutic use

Objective To observe the effect of Shenmai injection on congestive heart failure(CHF) and the effect on thyroid hormone as well as medicine security. Methods 52 patieits with CHF were enrolled,Shenmai injection was used with regular western medicine in the treatment. And observed its effect and test serum thyroid hormone: TSH,T3 ,T4 ,rT3. Another 50 CHF patients were enrolled as a control. Results The results of observation were that 25 cases were very effective,23 were effective,4 had no effect and the total effective rate was 92%. The results of control group were that 21 were very effective, 16 were effective, 13 had no effect and the total effective rate was 74%. The differences between the two groups were significant (P > 0.05). By comparing two thyroid hormone T3, T4, rT3, the observation T3 and T4 was obviously higher than the control. rT3 was lower than the control. Conclusion Shenmai injection could efficiently improve the heart function of CHF,cure arrhythmin and correct the illness caused by thyroid hormone.

Aim: To study the hydrofluoroalkane-driven(HFA-134a) salbutamol sulfate (SS) MDI formulation compositions and the respiratory tract absorption in rats. Methods: Solubility determination and orthogonal design were used to aid the screening of non-CFC SS MDI formulations. Rats were exposed to SS MDI via intubation inhalation. Fluorescent HPLC detection was developed to determine plasma SS concentration in rats given the selected SS MDI formulations. Analysis of the plasma drug level-time profiles was performed by the statistical moment approach. Results: Stable and homogeneous non-CFC SS MDI formulations were obtained. The developed HPLC method was validated and used to assay SS levels in the rats after inhalation of the MDI. AUC ratios of the SS/HFA-134a-driven MDI formulation to the reference SS MDI and CFC SS MDI formulation were 109. 86% and 135. 54%, respectively. Conclusion: It is proven that the absorption of the HFA-134a SS MDI formulation in rats is equivalent to the simulant formulation commercially available oversea and better than CFC formulation.

Objective:To observe the effectiveness and security of piperacillin sodium/sulbactam sodium in the treatment of bacte-rial infections and perform the pharmacoeconomics evaluation. Methods: Totally 126 patients with hand trauma bacterial infections were divided into the control group and the treatment group. The control group was given piperacillin sodium/tazobactam sodium 2. 5g, ivd, bid, while the treatment group was treated with piperacillin sodium/sulbactam sodium 1. 25g, ivd, bid. After 14-day treatment, the clinical therapeutic effect and adverse reactions of the two groups were observed, and the cost-minimization analysis was carried out. Results:The effective rate of the treatment group was 93. 65%while that of the control group was 92. 06%(P>0. 05). The bac-terial clearance rate of the treatment group was 96. 83%while that of the control group was 95. 24% (P>0. 05). The incidence of ad-verse reactions of the treatment group was 4. 76% (3/63) while that of the control group was 9. 52%(P>0. 05). The cost-effective-ness of piperacillin/sulbactam was significantly lower than that of the control group (P<0. 05). Conclusion: The effectiveness and safety of the two groups show no obvious differences in the treatment of hand trauma bacterial infections, and both have good antibacte-rial effect with low incidence of adverse reactions. For the better economic benefits, piperacillin /sulbactam is worthy of promoted ap-plication.

Objective To understand true feelings of patients with malignant tumor after implementing the protective medical treatment.In order to provide more humanized service for clinical nursing and to improve the job satisfaction of nurses.Methods The phenomenological methods of qualitative research was applied to carry out interviews with 12 patients to collected data.Then the data were analyzed.Results After reading,analysis,reflection,classification and refining the theme,we drew the following themes:(1)Before knowing diagnosis:half-believe and anxiety.(2) At the time of knowing diagnosis:luck,avoidance,acceptance and facing; (3) After knowing diagnosis:thirsting for information,low self-worth,improving self motivation.Conclusions We should not insist on hiding malignant tumor patients.Individualized and targeted measures should be taken to make patients cope with diagnosis better and improve the quality of their life.

Particulate matter is one of the important factors that have adverse effects on human health. It is generally known that the fine particles are more toxic than coarse ones, but some researchers have different opinion. Based on the analysis of the opinions, the factors that may influence the adverse effects of particulate matter on human health, including surface characteristics and adsorbed components, were discussed in the present paper. This paper will be helpful for the assessment of the toxicity of particulate matter.