Saffron and its active ingredients were found effective in the management of pain due to neurological and inflammatory causes. Therefore, this study was conducted to evaluate the effect of saffron on anxiety, fatigue and pain during labor progress. In this review study, articles in Persian and English language indexed in reputable databases, including Irandoc, Iranmedx, SID, Google scholar, Magiran, Scopus, web of science and PubMed were searched Articles that met the inclusion criteria were analyzed qualitatively. Out of 34040 studies, 6 articles were included. The mean score of anxiety and fatigue, active phase length score of the first and second stages of delivery were lower in the saffron consumer group compared to pharmacotherapy group. Saffron can increase cervical ripening in term pregnancies. Saffron had abortive effects. Saffron can be used as a facilitator of labour and a natural analgesic for labor pains.