It has got good effects that aqueous extracts of Sorbus tianschonica Rupr (AQ-ESTR) used for the treatment of chronic bronchitis, Pulmonary tuberculosis and edema etc in folk medicine. The pharmacological experiment showed that AQESTR had antibechic effect on mice induced by ammonia water, expectorant effect and antiasthmic effect on guinea pig induced by mixture of Ach-histamine. Cardiac Pharmacological experiment also showed AQESTR Produced significant bridycardia in mice. At the dose of 25mg/kg, AQESTR decreascd the heart rate and Prolonged the P-r interval of ECG in vivo, AQESTR decreased the contractive force of isolated atrial muscles rabbits in dose-dependent manner.

Objective To investigate the relationship between the efficacy of autologous cultured melanocyte transplantation and serum levels of interleukin-17 (IL-17) and FoxP3 in patients with vitiligo.Methods Forty patients with stable vitiligo vulgaris were included in this study,and received autologous cultured melanocyte transplantation.Six months after the transplantation,treatment efficacy was evaluated,and patients were classified into the successfully treated group (n =25) and unsuccessfully treated group (n =15).Peripheral blood was collected from all the patients before the transplantation,and enzyme-linked immunosorbent assay (ELISA) was performed to measure the serum levels of IL-17 and FoxP3.Statistical analysis was done using two independent samples t-test with the SPSS software (version 17.0).Results The successfully treated patients showed lower serum levels of IL-17 ((15.29 ± 7.86) vs.(43.88 ± 13.02) ng/L,P ＜ 0.05),but higher serum levels of FoxP3 ((6.08 ± 2.03) vs.(3.37 ± 1.81) ng/L,P ＜ 0.05) than the unsuccessfully treated patients.Conclusion The increased serum IL-17 and decreased serum FoxP3 may contribute to the failure of autologous cultured melanocyte transplantation in patients with vitiligo.

Objective To study the effects of tyrosol and oleanolic acid, two monomers of Fructus Ligustri Lucidi on the proliferation, tyrosinase activity and melanogenesis of cultured human melanocytes. Methods The cell proliferation was detected by MTT assay, the tyrosinase activity by dopa oxidase assay, the melanin content by NaOH - assay, and the mRNA level of tyrosinase ( TYR ) and tyrosinase related protein-1 (TRP-1) by RT-PCR. Results Incubation of tyrosol with cultured human melanocytes for 72 hours resulted in a significant stimulation of the tyrosinase activity and melanogenesis in a dose dependent manner. Compared with those in the cells without any treatment, the TYR and TRP-1 mRNA levels in the tyrosol -treated cells increased by 39.10% and 99.26%, respectively. Oleanolic acid also increased tyrosinase activity ( P

OBJECTIVE: To explore the impact of pre-pregnancy body mass index on baby's physical growth and nutritional status. METHODS: A total of 491 pairs of mother-infant were divided into 3 groups according to mother's pre-pregnancy body mass index (BMI): a pre-pregnancy low BMI group (BMI<18.5 kg/m², n=93), a pre-pregnancy normal BMI group (18.5 kg/m² ≤ BMI<24.0 kg/m², n=326), and a pre-pregnancy high BMI group (BMI ≥ 24.0 kg/m², n=72). Analysis of variance of repeated measurement data and the median percentage methods were used to compare the physical growth and nutritional status of babies in different groups. RESULTS: Baby's weight in the high BMI group were higher than that in the normal BMI and the low BMI group (F=3.958, P=0.020). The incidence of malnutrition in the low BMI group showed a tendency to decline along with the months (χ²=5.611, P=0.018), the incidence of overweight and obesity in the high and the normal BMI groups displayed a tendency to decline along with the months (χ²=18.773, 53.248, all P<0.001). Baby in the low BMI group had higher incidence of malnutrition while baby in the high BMI group had higher incidence of overweight and obesity. CONCLUSION Pregnancy BMI was correlated with the growth of baby. Too high or too low prepregnancy BMI exerts harmful effect on baby's weight and nutritional status. Medical workers should strengthen the education on women's pre-pregnancy to remind them keeping BMI at normal level.
Birth Weight ; Body Mass Index ; Female ; Humans ; Infant ; Infant Nutritional Physiological Phenomena ; Nutritional Status ; Obesity ; Overweight ; Pregnancy ; Weight Gain