Androgen treatment in boys with underdeveloped external genitalia requires close attention to avoid the side effects. The dose and duration of androgen have usually been decided according to the validation of the effects and the side effects. However, the dosage that showed the desirable effect or undesirable side effects already exceeded the optimal dosage. So the indicator to predict the effect of androgen is necessary for boys during androgen treatment. To evaluate serum 5alpha-androstane-3alpha, 17beta-diol glucuronide as this indicator we tried to obtain the correlation between the increase of penile length and serum 5alpha-androstane-3alpha, 17beta-diol-glucuronide and dihydro-testosterone during dihydrotestosterone treatment. While the mean serum level of 5alpha-androstane-3 alpha,17beta-diol glucuronide was higher than that of dihydrotestosterone in 17 patients without defects of androgen action,the opposite result was observed in 6 patients with defect of androgen action. The increase in penile length estimated by the calculation of the 8 weeks difference of deviation/normal S.D.significantly correlated with the serum 5alpha-androstane-3alpha, 17beta-diol glucuronide but not with serum DHT. Therefore the responsibility of the target cell to androgen seems to determine both the effect of androgen treatment and the serum level of 5alpha-androstane-3alpha, 17beta-diol glucuronide. In conclusion the serum 5alpha-androstane3alpha, 17beta-diol glucuronide could have a value as the indicator to predict the effect of androgen treatment in children with underdeveloped external genitalia.
Child* ; Dihydrotestosterone ; Genitalia ; Humans ; Male ; Penis

Based on the theory that benign prostatic hypertrophy may be induced by androgenic effect of testosterone derivatives, especially 5-alpha - dihydrotestosterone, on prostatic tissue, Chlormadinone acetate(CMA), potent oral synthetic antiandrogen was investigated in the treatment of benign prostatic hypertrophy. Twenty-two patients of prostatic hypertrophy were studied over six months period with a special reference to uroflowmetry and following results were obtained : 1) Chlormadinone acetate induced improvement of obstructive urinary symptoms in terms of uroflowmetric measurement. 2) It is very worthwhile to initiate medical treatment before undergoing any surgical intervention or when surgery is contraindicated.
Chlormadinone Acetate* ; Dihydrotestosterone ; Humans ; Prostatic Hyperplasia* ; Testosterone

A study of changes in testosterone(T) and dihydrotestosterone(DHT) serum concentration was undertaken in children from 6 months to 15 year old age to elucidate the differences in concentration of T and DHT in pediatric age. In addition, change in T: DHT ratio was studied in all children. In same age group there was large individual variation even though they were considered to be normal in T and DHT levels. The results were 1. The T concentration in blood did not increase until the age of l2 year old, but sharply increase(7-8 times) and sustained from the age of 12 year old. 2. DHT showed constant level until the age of 6 year old and somewhat increased level (1.5 times) from the 7 year old age until 11 year old age. So total serumT was considered to be increased a little and converted to DHT promptly from the age of 7. 3.Seeing the T : DHT ratio at the beginning of puberty, the conversion of T to DHTwas considered to be slow in activation time than the T production.
Adolescent ; Child ; Dihydrotestosterone* ; Humans ; Puberty ; Testosterone*

A study of changes in testosterone(T) and dihydrotestosterone(DHT) serum concentration was undertaken in children from 6 months to 15 year old age to elucidate the differences in concentration of T and DHT in pediatric age. In addition, change in T: DHT ratio was studied in all children. In same age group there was large individual variation even though they were considered to be normal in T and DHT levels. The results were 1. The T concentration in blood did not increase until the age of l2 year old, but sharply increase(7-8 times) and sustained from the age of 12 year old. 2. DHT showed constant level until the age of 6 year old and somewhat increased level (1.5 times) from the 7 year old age until 11 year old age. So total serumT was considered to be increased a little and converted to DHT promptly from the age of 7. 3.Seeing the T : DHT ratio at the beginning of puberty, the conversion of T to DHTwas considered to be slow in activation time than the T production.
Adolescent ; Child ; Dihydrotestosterone* ; Humans ; Puberty ; Testosterone*

Finasteride, an inhibitor of type II 5alpha-reductase, inhibits conversion of testosterone to dihydrotestosterone (DHT), resulting in a decrease in serum and scalp DHT levels which are believed to be pathogenic in androgenic alopecia. Oral finasteride has been shown to be effective in the treatment of hair loss in men, while its efficacy in women has remained controversial. Herein, we report 10 cases of female patterned hair loss in postmenopausal women treated with 1 mg/day of finasteride.
Alopecia ; Dihydrotestosterone ; Female* ; Finasteride* ; Hair* ; Humans ; Male ; Scalp ; Testosterone

The mechanism by which hypospadias is induced has not yet been clearly clarified. However insufficiency of the hypothalamo-pituitary-gonadal function has been suggested in the hypospadias while conflicting results have been demonstrated. Therefore, we assessed pituitary-gonadal function of hypospadias by measuring serum concentrations of testosterone, dihydrotestosterone and T:DHT ratio before and after HCG treatment. Pituitary LH and FSH responses to exogenous LHRH were also measured. The results were as follows ; 1. There were no significant differences in basal concentrations of serum testosterone and DHT between control and hypospadias. T:DHT ratio was not significantly different between two groups. 2. Concentrations of serum testosterone, DHT, LH and FSH were significantly elevated after HCG of LHRH administration except two patients with familial hypospadias. Also, T:DHT ratio showed normal level in hypospadias group after HCG stimulation. There results suggest that hypospadias may not be associated with abnormality in pituitary-gonadal function except familial hypospadias.
Dihydrotestosterone ; Female ; Gonadotropin-Releasing Hormone ; Gonads ; Humans ; Hypospadias* ; Male ; Testosterone

PURPOSE: recent studies have reported that the expression of Drg-1 is up-regulated by androgen. It has been suggested that Drg-1 gene be used as a molecular marker for prostate cancer therapies like PSA. To de termine the role of Drg-1 gene as a molecular marker during intermittent androgen deprivation(IAD) therapy, we investigated the expression of Drg-1 and compared it with PSA expression in human prostate cancer cell lines treated with dihydrotestosterone (DHT) continuously or intermittently. MATERIALS AND METHODS: Two prostate cancer cells having different status of androgen receptor [LNCaP (androgen dependent) and PC-3 (androgen independent)] were used in this study. To know the change in PSA and Drg-1 expression after DHT treatment the cells were cultured in steroid-free RPMI media for 24 hours. 10(-7) and 10(-8)M of DHT and 10(-7)M bicalutimide was added into the cells and then cultured for 72 hours. And we established in vitro IAD model using LNCaP cells. Northern analyses were performed to determine the expression level of both PSA and Drg-1genes. Also, western analyses were performed to determine the protein level of proliferating cellular nuclear antigen and androgen receptor. RESULTS: Transcripts of Drg-1 were detected in both LNCaP and PC-3 cells but PSA was not expressed in PC-3 cells. The expression of Drg-1gene in LNCaP cells was up-regulated by 10(-8)M of DHT like PSA gene and down-regulated by 10(-7)M bicalutamide. In the treatment of intermittent androgen deprivation, the expression pattern of Drg-1was similar to that of PSA. However, up-regulation of PSA was detected earlier than of Drg-1. CONCLUSIONS: Based on observation, Drg-1 was up-regulated by androgen and down-regulated by anti-androgen. This suggests that Drg-1gene is useful for determining the androgen independency of prostate cancer during IAD.
Cell Line ; Dihydrotestosterone ; Humans ; Prostate* ; Prostatic Neoplasms* ; Receptors, Androgen ; Up-Regulation

PURPOSE: The authors intended to analyze the operative results of mild to moderate hallux valgus treated with distal chevron metatarsal osteotomy. MATERIALS AND METHODS: Twenty six feet of twenty three patients were followed for more than 1 year after the distal chevron metatarsal osteotomy. Biplanar osteotomy with wedge resection was done when the distal metatarsal articular angle (DMAA) was increased. The mean age was 39 years, and the mean follow up period was 27 months. Clinically preoperative and postoperative AOFAS hallux MP-IP scale and satisfaction after the surgery were analyzed. Radiologically hallux valgus angle, the 1st intermetatarsal angle, DMAA and sesamoid position before and after the operation were analyzed. RESULTS: Distal chevron osteotomy was done in 15 cases and biplanar osteotomy was done in 11 cases. Clinically AOFAS scale was increased from 65.3 points preoperatively to 92.2 points postoperatively. Two patients were not satisfied with the results. Radiologically hallux valgus angle was decreased from 21.9degrees preoperatively to 8.5degrees postoperatively. The first intermetatarsal angle was decreased from 11.8degrees preoperatively to 6.7degrees postoperatively. DMAA was decreased from 11.8degrees preoperatively to 5.5degrees postoperatively. There was one case of minor wound infection. CONCLUSION: Distal chevron metatarsal osteotomy appears to be safe and satisfactory procedure for mild to moderate hallux valgus.
Azasteroids ; Dihydrotestosterone ; Follow-Up Studies ; Foot ; Hallux ; Hallux Valgus ; Humans ; Metatarsal Bones ; Osteotomy

Dual inhibition of both 5AR1 and 5AR2 by dutasteride provides greater and more consistent inhibition of the conversion of testosterone to dihydrotestosterone (DHT) than selective inhibition of 5AR2 alone. Beyond the benefit of symptomatic improvement in lower urinary tract symptoms/benign prostatic hyperplasia by dutasteride, recently, several pioneering studies have shown cancer-protective roles of dutasteride in localized prostate cancer. This can be summarized into two categories: management of biochemical recurrence after radical therapy and management of active surveillance of low-risk prostate cancer. This review concerns the rationale and superiority of dutasteride as a cancer-protective agent in localized prostate cancer and its possible mechanisms, reinforced by two recent randomized controlled trials, the Avodart after radical therapy for prostate cancer study ("ARTS") and reduction by dutasteride of clinical progression events in expectant management ("REDEEM") studies.
Dihydrotestosterone ; Prostate* ; Prostatic Hyperplasia ; Prostatic Neoplasms* ; Recurrence ; Testosterone ; Urinary Tract ; Dutasteride

We evaluated 15 children with hypospadias or micropenis for the presence of 5 a-reductase deficiency. Serum testosterone and dihydrotestosterone(DHT) concentrations were measured before and 3 days after HCG stimulation. Also, testosterone : dihydrotestosterone (T:DHT) conversion ratios were calculated in each children in order to determine the activity of 5 a-reductase. DHT was abnormally low in 14 children, and T:DHT conversion ratios were abnormal in 12 children in basal state. But T:DHT conversion ratios were abnormal in 2 children after HCG stimulation. In children, 5 a-reductase deficiency can not be diagnosed low serum DHT or abnormal T:DHT conversion ratio, but diagnosed abnormally high T:DHT conversion ratio after HCG stimulation.
Child* ; Cholestenone 5 alpha-Reductase* ; Dihydrotestosterone ; Female ; Humans ; Hypospadias ; Male ; Testosterone