OBJECTIVE: To explore the technique that distinguish pseudo-anacousia. METHODS: 60 cases were divided into three groups (normal group, deafness sensorineura group and pretending hearing loss group). They all had been tested by distortion products otoacoustic emissions technique. RESULTS: (1) The DPOAE incidence of normal group is 94.00%. the DPOAE incidence of deafness sensorineura group is 22.00%. There were significant differences at statistics in DPOAE incidence (P < 0.01). those proved that patients (deafness sensorineura group) were in hearing problem. (2) The DPOAE incidence of pretending hearing loss group is 93.00%, there were no significant differences at statistics in DPOAE incidence between normal group and pretending hearing loss group (P > 0.01), furthermore when behavior threshold is over 50 dBHL, DPOAE incidence is no score. CONCLUSION This study shows the technique can distinguish pretending hearing loss. The application of DPOAE can be used as a new tool in cases assessment of clinic forensic medicine.
Audiometry, Pure-Tone ; Auditory Threshold ; Deafness/physiopathology* ; Diagnosis, Differential ; Evoked Potentials, Auditory, Brain Stem ; Forensic Medicine ; Hearing Loss, Sensorineural/physiopathology* ; Humans ; Otoacoustic Emissions, Spontaneous

OBJECTIVETo observe the effect of Changji' an (CJA) oral liquid on the activated signal alterative intensity (ASAI) in intracranial algesthesia domain in patients with diarrhea type irritable bowel syndrome (IBS) due to Gan-Pi disharmony.

METHODSTwenty-four patients were randomly divided into 2 groups, 14 in the treated group and 10 in the control group, they were administrated with CJA and placebo respectively. The sensory threshold and score in the two groups recorded by rectal inflation test were compared and analyzed. The change of ASAI in intracranial algesthesia domain was analyzed by functional magnetic resonance imagine (fM-RI) during rectum being inflated with 30 ml, 60 ml, 90 ml and 120 ml of gas respectively.

RESULTSThe initial sensory thresholds in the two groups were insignificantly different, but significant difference did show between the two groups in urgent defecation threshold and pain threshold after treatment (P < 0.05). Comparison in visual simulative scores between the two groups after treatment at rectal inflated for 30 ml showed no significant difference, but it showed significant difference when the inflation was over 30 ml (P < 0.05). In the treated group, the ASAI in insula cortex when rectal inflation being 90 ml or 120 ml and that in thalamus when rectal inflation being 120 ml were significantly decreased (P < 0.05). But in the control group, it changed insignificantly after treatment.

CONCLUSIONThe treatment of CJA on Gan-Pi disharmony caused diarrhea type IBS might be effected by regulating the ASAI in intracranial insula cortex and thalamus.

Adult ; Aged ; Brain ; physiopathology ; Diagnosis, Differential ; Diarrhea ; etiology ; Drugs, Chinese Herbal ; therapeutic use ; Female ; Humans ; Irritable Bowel Syndrome ; complications ; drug therapy ; physiopathology ; Male ; Medicine, Chinese Traditional ; Middle Aged ; Pain Threshold ; drug effects ; Phytotherapy ; Sensory Thresholds ; drug effects ; Signal Transduction

AIMTo investigate the intrinsic mechanisms underlying spike programming at pyramidal neurons and interneurons in layer II/III of sensorimotor cortex.

METHODSElectrical signals at the cortical neurons were recorded in current clamp model with multi-clamp700B Amplifiers. Signals were inputted into pClamp and Origin for data acquisition and analyses.

RESULTSCompared to pyramidal neurons, interneurons express the higher capacity of spikes and the more stability of spike programming, which are mechanistically caused by lower threshold potentials and shorter refractory periods.

CONCLUSIONThe refractory periods and threshold potentials directly influence the programming of sequential spikes.

Action Potentials ; physiology ; Animals ; Animals, Newborn ; Cerebral Cortex ; cytology ; physiology ; Differential Threshold ; physiology ; Interneurons ; physiology ; Neurons ; physiology ; Patch-Clamp Techniques ; Pyramidal Cells ; physiology ; Rats ; Rats, Sprague-Dawley ; Refractory Period, Electrophysiological ; physiology ; Synaptic Transmission ; physiology