1.Impact of dietary oils and fats on lipid peroxidation in liver and blood of albino rats.
Mohammad El-Sayed Yassin El-Sayed HAGGAG ; Rafaat Mohamed ELSANHOTY ; Mohamed Fawzy RAMADAN
Asian Pacific Journal of Tropical Biomedicine 2014;4(1):52-58
OBJECTIVETo investigate the effects of different dietary fat and oils (differing in their degree of saturation and unsaturation) on lipid peroxidation in liver and blood of rats.
METHODSThe study was conducted on 50 albino rats that were randomly divided into 5 groups of 10 animals. The groups were fed on dietary butter (Group I), margarine (Group II), olive oil (Group III), sunflower oil (Group IV) and corn oil (Group V) for 7 weeks. After 12 h of diet removal, livers were excised and blood was collected to measure malondialdehyde (MDA) levels in the supernatant of liver homogenate and in blood. Blood superoxide dismutase activity (SOD), glutathione peroxidase activity (GPx), serum vitamin E and total antioxidant capacity (TAC) levels were also measured to determine the effects of fats and oils on lipid peroxidation.
RESULTSThe results indicated that no significant differences were observed in SOD activity, vitamin E and TAC levels between the five groups. However, there was significant decrease of GPx activity in groups IV and V when compared with other groups. The results indicated that feeding corn oil caused significant increases in liver and blood MDA levels as compared with other oils and fats. There were positive correlations between SOD and GPx, vitamin E and TAC as well as between GPx and TAC (r: 0.743; P<0.001) and between blood MDA and liver MDA (r: 0.897; P<0.001). The results showed also negative correlations between blood MDA on one hand and SOD, GPx, vitamin E and TAC on the other hand.
CONCLUSIONSThe results demonstrated that feeding oils rich in polyunsaturated fatty acids (PUFA) increases lipid peroxidation significantly and may raise the susceptibility of tissues to free radical oxidative damage.
Analysis of Variance ; Animals ; Diet ; Dietary Fats ; pharmacology ; Dietary Fats, Unsaturated ; pharmacology ; Female ; Glutathione Peroxidase ; blood ; Lipid Peroxidation ; drug effects ; Male ; Malondialdehyde ; blood ; Plant Oils ; pharmacology ; Rats ; Superoxide Dismutase ; blood
2.Progress on relationship between omega-3 polyunsaturated fatty acids and violent-aggressive behavior.
Journal of Forensic Medicine 2010;26(6):454-459
The relationship between omega-3 polyunsaturated fatty acids (PUFAs) and violent-aggressive behavior has been payed attention since 1980s. Their correlation was explored by many epidemiological investigations, and the effect of PUFAs on prevention or reduction of violent-aggressive behavior in different groups were also affirmed by some intervention studies. This article summarized the previous studies and reviewed the history of epidemiological or intervention studies on PUFAs and its relationship with violent-aggressive behavior. It also presented the possible influencing factors in these studies and possible mechanisms.
Aggression
;
Animals
;
Dietary Fats, Unsaturated/pharmacology*
;
Dietary Supplements
;
Docosahexaenoic Acids/pharmacology*
;
Eicosapentaenoic Acid/pharmacology*
;
Fatty Acids, Omega-3/pharmacology*
;
Fatty Acids, Omega-6/pharmacology*
;
Fishes
;
Folic Acid/metabolism*
;
Humans
;
Hydroxyindoleacetic Acid/metabolism*
;
Norepinephrine/metabolism*
;
Risk Factors
;
Serotonin/metabolism*
;
Violence/prevention & control*