Objective To research the care informed standardization based on the situation of incomprehensive content informed and low compliance satisfaction for stroke patients.Methods The questionnaire of stroke patients' care informed by self-designed in 2008 was using to survey 100 cases of stroke patients admitted to hospital as a control group,including the content,the way,the advice and satisfaction of this survey.The patients admitted from July 2009 to July 2011 were selected as experimental group and treated with standardized training of nurses and information and surveyed with their satisfaction for nursing.Results All the subjects were admitted in hospital primitively and the mean stay in hospital was more than 15 days.General conditions - age,gender and degree of educationwere not found differently beteeen the two groups ( P ＞0.05 ).Satisfaction degree was(3.22 ±0.65)in experimental group,and(2.81 ±0.73)in control group,respectively,the different was significant (t =4.18,P ＜0.01 ).In experimental group,the admitted nursing notification score was(22.70 + 2.23),therapy nursing notification was(21.86 ± 3.51 ),healthy instruction score was (21.66 ±4.22),discharged nursing information score was(23.20 ±3.40) ; in control group,those score were ( 15.23 ± 3.50),( 14.08 ± 4.64 ),( 13.42 ± 4.20) and ( 19.45 ± 5.70),respectively; the differences were significantly(t =18.00,13.37,13.85,5.65,respectively; P ＜0.01).Conclusions Research and implementation on the care informed normative for stroke patients can improve the quality of care,patient satisfaction and promote health education standards orderly and efficiently.

Objective To study the effect of ventilator cluster nursing in mechanically ventilated patients in Craniocerebral Department.Methods Totals of 60 cases of mechanically ventilated patients admitted during January 2010 to July 2011 in Craniocerebral Department wards were the experimental group,which received ventilator cluster nursing,including raising bed 30-45 °,prevention of peptic ulcer,trying to stop sedatives everyday,prevention of deep vein thrombosis,oral care,attraction of subglottic secretions and hand hygiene.A total of 58 cases of mechanically ventilated patients from June 2008 to December 2009 in the same department were the control group,receiving conventional methods of nursing.Incidence,duration of mechanical ventilation and mortality of ventilator-associated pneumonia (VAP) in two groups were compared.Results The incidence,duration of mechanical ventilation and mortality of VAP were respectively 40.0％,(189.7 ± 64.5) h and 25.0％ in the experimental group,72.4％,(331.3 ± 86.7) h and 51.7％ in the control group,and the differences were statistically significant (x2/t =12.571,10.089,8.928,respectively; P ＜0.05).Conclusions Ventilator cluster nursing can reduce the incidence and mortality of VAP,as well as shorten the duration of mechanical ventilation in mechanically ventilated patients in Craniocerebral Department.

Numerous randomised controlled trials have suggested the positive effects of acupuncture on chronic obstructive pulmonary disease (COPD). However, the underlying therapeutic mechanisms of acupuncture for COPD have not been clearly summarized yet. Inflammation is central to the development of COPD. In this review, we elucidate the effects and underlying mechanisms of acupuncture from an anti-inflammatory perspective based on animal studies. Cigarette smoke combined with lipopolysaccharide is often used to establish animal models of COPD. Electroacupuncture can be an effective intervention to improve inflammation in COPD, and Feishu (BL13) and Zusanli (ST36) can be used as basic acupoints in COPD animal models. Different acupuncture types can regulate different types of inflammatory cytokines; meanwhile, different acupuncture types and acupoint options have similar effects on modulating the level of inflammatory cytokines. In particular, acupuncture exerts anti-inflammatory effects by inhibiting the release of inflammatory cells, inflammasomes and inflammatory cytokines. The main underlying mechanism through which acupuncture improves inflammation in COPD is the modulation of relevant signalling pathways: nuclear factor-κB (NF-κB) (e.g., myeloid differentiation primary response 88/NF-κB, toll-like receptor-4/NF-κB, silent information regulator transcript-1/NF-κB), mitogen-activated protein kinase signalling pathways (extracellular signal-regulated kinase 1/2, p38 and c-Jun NH2-terminal kinase), cholinergic anti-inflammatory pathway, and dopamine D2 receptor pathway. The current synthesis will be beneficial for further research on the effect of acupuncture on COPD inflammation. Please cite this article as: Jiang LH, Li PJ, Wang YQ, Jiang ML, Han XY, Bao YD, Deng XL, Wu WB, Liu XD. Anti-inflammatory effects of acupuncture in the treatment of chronic obstructive pulmonary disease. J Integr Med. 2023; 21(6): 518-527.
Animals ; NF-kappa B/metabolism* ; Pulmonary Disease, Chronic Obstructive/drug therapy* ; Acupuncture Therapy ; Cytokines ; Disease Models, Animal ; Inflammation/therapy*

Objective: To analyze the clinical and molecular diagnostic status of Fanconi anemia (FA) in China. Methods: The General situation, clinical manifestations and chromosome breakage test and genetic test results of 107 pediatric FA cases registered in the Chinese Blood and Marrow Transplantation Registry Group (CBMTRG) and the Chinese Children Blood and Marrow Transplantation Registry Group (CCBMTRG) from August 2009 to January 2022 were analyzed retrospectively. Children with FANCA gene variants were divided into mild and severe groups based on the type of variant, and Wilcoxon-test was used to compare the phenotypic differences between groups. Results: Of the 176 registered FA patients, 69 (39.2%) cases were excluded due to lack of definitive genetic diagnosis results, and the remaining 107 children from 15 hospitals were included in the study, including 70 males and 37 females. The age at transplantation treatment were 6 (4, 9) years. The enrolled children were involved in 10 pathogenic genes, including 89 cases of FANCA gene, 7 cases of FANCG gene, 3 cases of FANCB gene, 2 cases of FANCE gene and 1 case each of FANCC, FANCD1, FANCD2, FANCF, FANCJ, and FANCN gene. Compound heterozygous or homozygous of loss-of-function variants account for 69.2% (72/104). Loss-of-function variants account for 79.2% (141/178) in FANCA gene variants, and 20.8% (37/178) were large exon deletions. Fifty-five children (51.4%) had chromosome breakage test records, with a positive rate of 81.8% (45/55). There were 172 congenital malformations in 80 children.Café-au-Lait spots (16.3%, 28/172), thumb deformities (16.3%,28/172), polydactyly (13.9%, 24/172), and short stature (12.2%, 21/172) were the most common congenital malformations in Chinese children with FA. No significant difference was found in the number of congenital malformations between children with severe (50 cases) and mild FANCA variants (26 cases) (Z=-1.33, P=0.185). Conclusions: FANCA gene is the main pathogenic gene in children with FA, where the detection of its exon deletion should be strengthened clinically. There were no phenotypic differences among children with different types of FANCA variants. Chromosome break test is helpful to determine the pathogenicity of variants, but its accuracy needs to be improved.
Male ; Female ; Humans ; Child ; Fanconi Anemia/genetics* ; Chromosome Breakage ; Retrospective Studies ; Exons ; China/epidemiology*