With with use of Tono-pen, we investigated the degree of reduction in intraocular pressure of the Honan intraocular pressure reducer(HIPR) with preoperative use of dichlorphenamide and mannitol or without. Seventy five patients scheduled for cataract surgery were divided into 4 groups by preoperative medication. Intraocular pressure was measured before preoperative medication and in process of time after external compression with the Honan intraocular pressure reducer(HIPR) following retrobulbar injection. There was no additive effect on the reduction of intraocular pressure with the preoperative use of dichlorphenamide and mannitol. A rapid initial reduction in intraocular presure over the first 5 minutes of compression was followed by a more gradual reduction from 5 to 20 minutes. We concluded that the compression of up to 20 minutes duration without the preoperative use of dichlorphenamide and mannitol is adequate.
Cataract* ; Dichlorphenamide ; Humans ; Intraocular Pressure* ; Mannitol ; Premedication*

Although drug-induced transient myopia has been reported to be caused by the use of several drugs, it is very rare and the causes are still uncertain. A considerable literature has accumulated relating the occasional occurrence of myopia in patients receiving carbonic anhydrase inhibitors, especially acetazolamide. However the authors could not find any literature concerning transient myopia induced by dichlorphenamide. The authors reporthed here a case of transient myopia after dichlorphenamide in a patient with serous detachment of the macula with a review of the literatures.
Acetazolamide ; Carbonic Anhydrase Inhibitors ; Dichlorphenamide* ; Humans ; Myopia*

Although drug-induced transient myopia has been reported to be caused by the use of several drugs, it is very rare and the causes are still uncertain. A considerable literature has accumulated relating the occasional occurrence of myopia in patients receiving carbonic anhydrase inhibitors, especially acetazolamide. However the authors could not find any literature concerning transient myopia induced by dichlorphenamide. The authors reporthed here a case of transient myopia after dichlorphenamide in a patient with serous detachment of the macula with a review of the literatures.
Acetazolamide ; Carbonic Anhydrase Inhibitors ; Dichlorphenamide* ; Humans ; Myopia*

To study bone resorption mechanism, effect of LPS on the 45Ca release from fetal rat ulnae and radii, and effects of carbonic anhydrase inhibitors on the LPS-induced bone resorption in organ culture were studied. Ulnae and radii were removed from 19 day old fetal rats, prelabelled by subcutaneous injection of 200micronCi 45CaCl2 into their mother on the 17th day of gestation. Radioactivities of 45Ca released into media were determined after 24, 48 and 72 hours. Effects of LPS and carbonic anhydrase inhibitors were observed by the ratio of % release of 45Ca between paired control and experimental group. The observed results were as follows: 1. LPS(1microng/ml) supplemented in media for 72hours increased the 45Ca release significantly after 48 and 72 hours of culture and LPS(10microng/ml) increased the 45Ca release significantly after 72 hours of culture. 2. LPS-induced 45Ca release was not inhibited significantly by 1mM sulfanilamide but inhibited significantly by 10mM sulfanilamide after 48 and 72 hours of culture. 3. LPS-induced 45Ca release was not inhibited significantly by 0.1mM dichlorphenamide but inhibited significantly by 1mM dichlorphenamide after 48 and 72 hours of culture. 4. LPS-induced 45Ca release was not inhibited significantly by 1mM acetazolamide but inhibited significantly by 5mM acetazolamide after 72 hours of culture.
Acetazolamide ; Animals ; Bone Resorption* ; Carbon* ; Carbonic Anhydrase Inhibitors* ; Carbonic Anhydrases* ; Dichlorphenamide ; Humans ; Injections, Subcutaneous ; Mothers ; Organ Culture Techniques ; Pregnancy ; Radioactivity ; Rats ; Ulna