1.Effect of the Starting Point of Half-Pin Insertion on the Insertional Torque of the Pin at the Tibia.
Sung Jae KIM ; Sung Hwan KIM ; Young Hwan KIM ; Yong Min CHUN
Yonsei Medical Journal 2015;56(1):154-158
PURPOSE: The authors have observed a failure to achieve secure fixation in elderly patients when inserting a half-pin at the anteromedial surface of the tibia. The purpose of this study was to compare two methods for inserting a half-pin at tibia diaphysis in elderly patients. MATERIALS AND METHODS: Twenty cadaveric tibias were divided into Group C or V. A half-pin was inserted into the tibias of Group C via the conventional method, from the anteromedial surface to the interosseous border of the tibia diaphysis, and into the tibias of Group V via the vertical method, from the anterior border to the posterior surface at the same level. The maximum insertion torque was measured during the bicortical insertion with a torque driver. The thickness of the cortex was measured by micro-computed tomography. The relationship between the thickness of the cortex engaged and the insertion torque was investigated. RESULTS: The maximum insertion torque and the thickness of the cortex were significantly higher in Group V than Group C. Both groups exhibited a statistically significant linear correlation between torque and thickness by Spearman's rank correlation analysis. CONCLUSION: Half-pins inserted by the vertical method achieved purchase of more cortex than those inserted by the conventional method. Considering that cortical thickness and insertion torque in Group V were significantly greater than those in Group C, we suggest that the vertical method of half-pin insertion may be an alternative to the conventional method in elderly patients.
Aged
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Aged, 80 and over
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*Bone Nails
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Bone Screws
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Diaphyses/radiography/surgery
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*External Fixators
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Female
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Humans
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Male
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Tibia/radiography/*surgery
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*Torque
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X-Ray Microtomography
2.The applications of homemade bone cement mold in limb salvage operation for diaphyseal tumor.
Bin WANG ; Zhong ZHU ; Guo-cheng XU ; Wen-jie ZHANG
China Journal of Orthopaedics and Traumatology 2009;22(9):716-717
Adult
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Aged
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Aged, 80 and over
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Bone Cements
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Bone Neoplasms
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diagnostic imaging
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surgery
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Diaphyses
;
diagnostic imaging
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pathology
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surgery
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Female
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Humans
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Limb Salvage
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methods
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Male
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Middle Aged
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Radiography
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Treatment Outcome
3.Establishment of Efficacy and Safety Assessment of Human Adipose Tissue-Derived Mesenchymal Stem Cells (hATMSCs) in a Nude Rat Femoral Segmental Defect Model.
Hyung Jun CHOI ; Jong Min KIM ; Euna KWON ; Jeong Hwan CHE ; Jae Il LEE ; Seong Ryul CHO ; Sung Keun KANG ; Jeong Chan RA ; Byeong Cheol KANG
Journal of Korean Medical Science 2011;26(4):482-491
Human adipose tissue-derived mesenchymal stem cell (hATMSC) have emerged as a potentially powerful tool for bone repair, but an appropriate evaluation system has not been established. The purpose of this study was to establish a preclinical assessment system to evaluate the efficacy and safety of cell therapies in a nude rat bone defect model. Segmental defects (5 mm) were created in the femoral diaphyses and transplanted with cell media (control), hydroxyapatite/tricalcium phosphate scaffolds (HA/TCP, Group I), hATMSCs (Group II), or three cell-loading density of hATMSC-loaded HA/TCP (Group III-V). Healing response was evaluated by serial radiography, micro-computed tomography and histology at 16 weeks. To address safety-concerns, we conducted a GLP-compliant toxicity study. Scanning electron microscopy studies showed that hATMSCs filled the pores/surfaces of scaffolds in a cell-loading density-dependent manner. We detected significant increases in bone formation in the hATMSC-loaded HA/TCP groups compared with other groups. The amount of new bone formation increased with increases in loaded cell number. In a toxicity study, no significant hATMSC-related changes were found in body weights, clinical signs, hematological/biochemical values, organ weights, or histopathological findings. In conclusion, hATMSCs loaded on HA/TCP enhance the repair of bone defects and was found to be safe under our preclinical efficacy/safety hybrid assessment system.
Adipose Tissue/*cytology
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Animals
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Biocompatible Materials/therapeutic use
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Bone Diseases/pathology/radiography/*therapy
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Bone Regeneration/physiology
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Calcium Phosphates/therapeutic use
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Diaphyses/radiography/surgery/ultrastructure
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Disease Models, Animal
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Durapatite/therapeutic use
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Femur/*pathology/radiography/surgery
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Humans
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Male
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*Mesenchymal Stem Cell Transplantation
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Mesenchymal Stem Cells/*cytology
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Rats
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Rats, Nude
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Tissue Engineering
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Tomography, X-Ray Computed
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Transplantation, Heterologous