Objective:To assess the effects of ohmefentanyl(OMF),a potent and selective agonist for ? opiate receptor,on respiratory function in chronic hypoxic rats.Methods:Totally 86 healthy male SD rats were randomly divided into the normal group ( n =20) and chronic hypoxic model group( n =66).The chronic hypoxic rat model was established by intravenous injections of papain once a week for 6 times.Rats in normal control group received OMF injection( n =10) and artificial cerebrospinal fluid(aCSF) injection( n =10).Rats in chronic hypoxic group were further divided into cerebroventricular administration group( n =48) and nucleus tractus solitari(NTS) administration group( n =18).Rats in cerebroventricular administration group received naloxone( n =12) and OMF( n =12),and the other 24 rats were taken as control.Rats in NTS group received OMF( n =9) and aCSF( n =9).The respiratory rate(RR) and tidal volume(V T) were determined 5,15,30,45 and 60 min after injection.Results:Intracerebroventricular administration of OMF in normal rats resulted in a significant decrease in RR and V T ( P

Objective:To investigate the method and effect of correcting upper eyelid depression with released orbital diaphragmatic fat.Methods:From January 2017 to June 2020, there were 26 female patients with upper eyelid depression in this department of Hebei Chengde Stomatological Hospital. The patients aged 22-54 years, with average 43 years. An external mass orbital diaphragm fat release reverse folding repositioning with fat placement in the upper lid depression was performed in 26 patients. An incision about 4 mm long was made in the middle and lateral of the orbital diaphragm to ensure the integrity of the orbital diaphragm as far as possible. The photos of beauty seekers before and 6 months after operation were compared to observe the correction effect of upper eyelid depression and the shape of upper eyelid.Results:All 26 patients had one-stage healing of the surgical incision without infection, with inconspicuous incisional scarring. At 6 months postoperatively, 18 patients had satisfactory results; 1 patient had improved results due to insufficient fat; and 1 patient had poor results due to too little fat and poor filler placement, which was later improved by autologous fat grafting.Conclusions:External mass orbital fat release reverse folding repositioning for correction of upper eyelid depressions is a surgical procedure with obvious results, little trauma, and following the principle of anatomical recovery, which is worthy of clinical application.