Objective:To explore the clinical effect of total hip arthroplasty (THA) through Watson-Jone approach on hip osteoarthritis caused by advanced Kaschin-Beck disease (KBD).Methods:Using a prospective design, patients with hip osteoarthritis caused by advanced KBD admitted to Second Department of Orthopaedics, Hulun Buir People's Hospital from May 2014 to October 2017 were selected as research objects. THA through Watson-Jone approach was used to treat, all patients were treated with non-bone cement biological prosthesis. Visual analogue scale (VAS) score and Harris hip score were used to evaluate the pain, function, and hip flexion of patients before and after operation. At the same time, patients were evaluated by postoperative X-ray to observe the occurrence of complications.Results:A total of 14 patients (17 hips) were included in the study, including 6 males (7 hips) and 8 females (10 hips), the average age was 62.3 years old, and the duration of the disease was 7 - 20 years. The VAS scores [(2.15 ± 1.20), (1.07 ± 0.58) points] at 2 and 24 months after operation were significantly lower than that before operation [(8.22 ± 0.47) points, P < 0.05], and Harris scores [(87.93 ± 4.98), (91.07 ± 3.99) points] were significantly higher than that before operation [(35.72 ± 6.40) points, P < 0.05]. X-ray evaluation showed no complications such as loosening, dislocation, and fracture around the prosthesis, joint infection, and gluteus medius gait. Conclusions:THA through Watson-Jone approach is effective in the treatment of patients with hip osteoarthritis caused by advanced KBD. It has significantly reduced hip pain and improved hip range of motion, with a lower incidence of complications.