PURPOSE: To evaluate the correlation between diabetic macular edema diagnosed with stereoscopic slit-lamp and retinal thickness analyzer (RTA). METHODS: Diabetic macular edema diagnosed with stereoscopic slit-lamp was compared to indices of RTA in 50 eyes of 32 persons which were diagnosed clinically with diabetic retinopathy. RESULTS: From stereoscopic slit-lamp results, diabetic macular edema was present in 39 of 50 eyes, and absent in 11 of 50. Foveal average thickness out of the RTA indices was 209.7+/-58.5 micrometer from observing diabetic macular edema clinically and 199.4+/-47.3 micrometer from not observing diabetic macular edema clinically. Statistically significant differences were found in average foveal thickness between the 2 groups (p=0.013). CONCLUSIONS: RTA appears to serve as a useful and sensitive tool for the diagnosis of diabetic macular edema.
Diabetic Retinopathy ; Diagnosis* ; Humans ; Macular Edema* ; Retinaldehyde*

Authors recorded standard electroretinogram in two groups of diabetic patients. Group A, consisted of 60 eyes with no visible diabetic retinopathy and Group B, 30 eyes with mild nonproliferative diabetic retinopathy. The electroretinogram was recorded according to the standard electroretinogram procedure recommanded by the ISCEV. In rod and cone response, the amplitude of b wave were 329.0+/-46.9 microvoltin Group A and 308.8+/-37.8 microvoltin Group B. The implicit time of b wave were 40.5+/-3. 0microvoltin Group A and 45.8+/-5.4microvolti n Group B. The summed amplitude of oscillatory potentials were 125.7+/-38.7microvolt in Group A and 112.0+/-17.7microvoltin Group B. Above results indicate that for the disgnostic criteria for diabetic retinopathy, the amplitude and implict time of b wave, and the summed amplitude of oscillatory potentials in maximal combined response were useful. On receiver operating characteristic(ROC) curves in maximal combined response, cut off value for the amplitude and implicit time of b wave were 315 microvoltand 42ms espectively. Cut off value for the summed amplitude of oscillatory potentia-als was 118 microvolt. In results, on ROC curve, the implicit time of b wave in maximal combined response was most accurate, and the summed amplitude of oscillary potentials was the next, followed by the amplitude of b wave in the maximal combined response.
Diabetic Retinopathy* ; Early Diagnosis* ; Humans ; ROC Curve

Sixty diabetic cystopathy patients (symptomatic DCP, 4.9%) among 1236 patients of diabetes mellitus (DM) from May, 1995 to June, 1996 were analyzed to ascertain the usefulness of urodynamic study in the diagnosis of DCP. The mean age was 58 (24--80) years and mean duration of DM was 9 (1~30) years. 36 (60%) patients had diabetic neuropathy, 31 (52%) had diabetic retinopathy and 4 (7%) had diabetic nephropathy. DM was managed by insulin pump (DIABECARETM, 52%) and subcutaneous insulin injection (42%). In residual urine and voiding diaries, residual urine volume more than 40ml was 83%, voiding interval less than 2 or more than 5 hours was 67% and voiding amount less than 200ml or more than 400ml was 48%. According to urodynamic findings, patients were classified as detrusor areflexia (63%), impaired detrusor contractility (18%), detrusor instability (15%) and normal detrusor contraction (3%). There were no significant differences of age, semm-HbA1C, treatment method and duration of diabetes mellitus among above groups. Mean duration of DM in irritative symptom group (32%), combined symptom group (23%) and obstructive symptom group (45%) were 2 years, 8 years and 15 years respectively (p<0.001). The shape of the cystometrographic curve was not influenced by the rate of bladder filling (40ml/min versus 100ml/min). In conclusion, because DCP is marked by insidious onset and progression with minimal symptoms, DCP can be early diagnosed using urodynamic study especially in patients with voiding symptoms and 1ong.DM duration.
Diabetes Mellitus ; Diabetic Nephropathies ; Diabetic Neuropathies ; Diabetic Retinopathy ; Diagnosis ; Humans ; Insulin ; Urinary Bladder ; Urodynamics*

PURPOSE: This study was performed to determine the time of initial fundus examination after the diagnosis of diabetes and the probability of diabetic retinopathy in the primary eye clinic. METHODS: 158 diabetes who visited on primary eye clinic between September 2003 and February 2004 were enrolled. We perfomed fundus examination with stereoscopic photograph. and made some questions about the delyed fundus examination. RESULTS: Among 158 patients (Mean age 59.56 +/- 9.66), diabetic retinopathy was demonstrated in 59 (37.3%). The average delayed time of initial fundus examination was 5.98 +/- 5.30years. The longer duration of the interval, the higer was the prevalence of diabetic retinopathy and the more severe retinopathy was found. The common reason of delayed fundus examination after diagnosis of diabetes was `having no symptom' (50.0%) and `not knowing of diabetic ocular complication' (15.0%). CONCLUSIONS: We concluded the prevalence of diabetic retinopathy in primary eye clinic was not remarkable different in tertiary hospital. In order to prevent vision threatening diabetic retinopathy, We should perfom the fundus examination before becoming too advanced. In primary eye clinic as well as tertiary hopital, education of diabetic patients and thorough understanding of diabetic retinopathy must be needed.
Diabetic Retinopathy* ; Diagnosis ; Education ; Humans ; Prevalence ; Tertiary Care Centers

PURPOSE: To evaluate the influence of peripapillary atrophy on the progress of diabetic retinopathy. METHODS: Interval between the diagnosis of diabetes and the onset of diabetic retinopathy was compared between 77 eyes of 50 patients with peripapillary atrophy and 253 eyes of 172 patients without peripapillary atrophy who visited the Korea university ophthalmology department between January 2002 and May 2002, No one had glaucoma or high myopia. Pepipapillary atrophy was classified by severity and compared. RESULTS: Time to the onset of nonproliferative diabetic retinopathy was longer in the patients with peripapillary atrophy (13.7 years) than the patients without peripapillary atrophy (11.2 years) (pdiabetic retinopathy was also longer in eyes with peripapillary atrophy(21.1 years) than those without peripapillary atrophy (12.3 years) (pdiabetic retinopathy was delayed in the patients with peripapillary atrophy irrelevant to glaucoma, high myopia or tessellated fundus. The mild peripapillary atrophy had the same effect. But the extent of peripapillary atrophy had no relation with the progression of diabetic retinopathy.
Atrophy* ; Diabetic Retinopathy* ; Diagnosis ; Glaucoma ; Humans ; Korea ; Myopia ; Ophthalmology

The diagnosis of diabetics itself was frequently delayed in diabetic patients diagnosed over 30 years old. Therefore, fundus examination should be carried out at the time of diagnosis. The purpose of this study was to determine the delayed time of the initial fundus examination by ophthalmologists after diagnosis of diabetes and the reason for not having fundus examination in diabetic patients diagnosed when they were over 30 years of age. From January, 1998 to July, 1998, two hundred fifty-seven such diabetic patients were examined fundus for the first time in Department of Ophthalmology of the Kyungpook National University Hospital. Among these patients,the average delayed time of the initial fundus examination by ophthalmologists after the diagnosis of diabetes was 6.2 years and the morbidity rate was 39.7% (102 patients). At these patients,mild,moderate and severe nonproliferative diabetic retinopathy were 22.6% (58 patients), 10.1% (26 patients),2.7% (7 patients)respectively and proliferative diabetic retinopathy was 4.3% (11 patients). In conclustion, the delayed fundus examination was due to not knowing about timely necessity of the fundus examination. Diabetic patients as well as doctors who treat them should beeducated for the fundus examination at the time of diagnosis.
Adult ; Diabetic Retinopathy* ; Diagnosis ; Gyeongsangbuk-do ; Humans ; Ophthalmology

A design scheme of a tele-screening system for diabetic retinopathy (DR) has been proposed, especially the communication subsystem. The scheme uses serial communication module consisting of ARM 7 microcontroller and relays to connect remote computer and fundus camera, and also uses C++ programming language based on MFC to design the communication software consisting of therapy and diagnostic information module, video/audio surveillance module and fundus camera control module. The scheme possesses universal property in some remote medical treatment systems which are similar to the system.
Computers ; Diabetic Retinopathy ; diagnosis ; Humans ; Programming Languages ; Telemedicine ; instrumentation

The high-pace rise in advanced computing and imaging systems has given rise to a new research dimension called computer-aided diagnosis (CAD) system for various biomedical purposes. CAD-based diabetic retinopathy (DR) can be of paramount significance to enable early disease detection and diagnosis decision. Considering the robustness of deep neural networks (DNNs) to solve highly intricate classification problems, in this paper, AlexNet DNN, which functions on the basis of convolutional neural network (CNN), has been applied to enable an optimal DR CAD solution. The DR model applies a multilevel optimization measure that incorporates pre-processing, adaptive-learning-based Gaussian mixture model (GMM)-based concept region segmentation, connected component-analysis-based region of interest (ROI) localization, AlexNet DNN-based highly dimensional feature extraction, principle component analysis (PCA)- and linear discriminant analysis (LDA)-based feature selection, and support-vector-machine-based classification to ensure optimal five-class DR classification. The simulation results with standard KAGGLE fundus datasets reveal that the proposed AlexNet DNN-based DR exhibits a better performance with LDA feature selection, where it exhibits a DR classification accuracy of 97.93% with FC7 features, whereas with PCA, it shows 95.26% accuracy. Comparative analysis with spatial invariant feature transform (SIFT) technique (accuracy—94.40%) based DR feature extraction also confirms that AlexNet DNN-based DR outperforms SIFT-based DR.
Classification ; Dataset ; Diabetic Retinopathy ; Diagnosis ; Passive Cutaneous Anaphylaxis

Over the past decade, significant advances have been made in both the diagnosis and treatment of diabetic retinopathy. Ultrawide field fundus photography and spectral domain optical coherence tomography have allowed more accurate, convenient, and early diagnosis of diabetic retinopathy. Numerous randomized clinical trials have demonstrated the effectiveness of anti-vascular endothelial growth factor agents for the treatment of diabetic retinopathy, although more work is necessary in terms of long-term clinical outcomes and socioeconomic costs associated with these treatments.
Diabetic Retinopathy* ; Diagnosis* ; Early Diagnosis ; Endothelial Growth Factors ; Epidemiology ; Photography ; Tomography, Optical Coherence

PURPOSE: To evaluate the fundus findings of diabetes mellitus (DM) patients who visited the department of ophthalmology for the first time and to emphasize the importance of early diagnosis and treatment of diabetic retinopathy (DR). METHODS: After 84 DM patients were asked to respond to the questionaire regarding previous medical histories and underwent the general ophthalmological examination, their fundus findings were analyzed and the incidence rates of DR were evaluated according to the prevalence period of DM and the compliance with treatment for DM as well. RESULTS: Motivations of visit to ophthalmology were impairment of visual acuity (46.4%) and requests by medical doctors (35.7%), examinations for other ophthalmologic diseases (13.1%), and mass media (1.2%) in the order. Diagnosis rate of DR in 84 patients who visited our department for the first time was 52.4% and among these, occupying rates of non-proliferative DR and proliferative DR were 47.7% and 52.3% respectively. Incidence rates of DR according to prevalence period of DM were 26.9% in 5 and 10 15 years. Incidence rates of DR according to compliance with treatment for DM were 45%, 50% in regularly and irregularly treated patients respectively. CONCLUSIONS: These results showed that high percentage of DM patients did not take the ophthalmological examination and treatment even though they already had various degree of DR. In these patients, the longer prevalence period of DM, the higher incidence rate of DR, and irregularly treated patients tended to increase the incidence rate of DR compared to regularly treated patients. Thus we emphasize that active public information is required urgently on the importance of early diagnosis and treatment of DR to primary medical doctors to care DM patients as well as DM patients themselves.
Compliance ; Diabetes Mellitus* ; Diabetic Retinopathy ; Diagnosis ; Early Diagnosis ; Humans ; Incidence ; Mass Media ; Ophthalmology ; Prevalence ; Visual Acuity