1.Associations among Body Mass Index, Insulin Resistance, and Pancreatic beta-Cell Function in Korean Patients with New-Onset Type 2 Diabetes.
Jin Ook CHUNG ; Dong Hyeok CHO ; Dong Jin CHUNG ; Min Young CHUNG
The Korean Journal of Internal Medicine 2012;27(1):66-71
BACKGROUND/AIMS: We investigated the associations among body mass index (BMI), insulin resistance, and beta-cell function in Korean patients newly presenting with type 2 diabetes. METHODS: In total, 132 patients with new-onset type 2 diabetes mellitus were investigated. A standard 75-g oral glucose tolerance test was performed, and the indices of insulin secretion and insulin resistance were calculated. RESULTS: A higher BMI was associated with higher homeostasis model assessment values for insulin resistance (HOMA-IR), homeostasis model assessment of beta-cell function (HOMA-beta), and insulinogenic index as well as lower levels of insulin sensitivity index composite (ISIcomp) and disposition index (DI). In multiple regression models, BMI had independent positive associations with HOMA-IR, ISIcomp, and HOMA-beta and inverse associations with the DI. CONCLUSIONS: Our results showed that BMI had independent positive associations with indices of insulin resistance and an inverse association with beta-cell function adjusted for insulin resistance in Korean patients newly presenting with type 2 diabetes.
*Asian Continental Ancestry Group
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Biological Markers/blood
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Blood Glucose/metabolism
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*Body Mass Index
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Diabetes Mellitus, Type 2/blood/diagnosis/*ethnology/physiopathology
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Female
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Glucose Tolerance Test
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Hemoglobin A, Glycosylated/metabolism
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Humans
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Insulin/blood
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Insulin Resistance/*ethnology
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Insulin-Secreting Cells/*metabolism
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Linear Models
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Logistic Models
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Male
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Middle Aged
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Multivariate Analysis
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Predictive Value of Tests
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Republic of Korea/epidemiology
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Risk Assessment
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Risk Factors