1.A Case of Congenital Nephrogenic Diabetes Insipidus.
Jae Sook KIM ; Sook Hee KONG ; Choong Hee KIM
Journal of the Korean Pediatric Society 1983;26(9):909-915
No abstract available.
Diabetes Insipidus, Nephrogenic*
2.A Case of Nephrogenic Diabetes Insipidus Complicated with Bilateral Hydroureteronephrosis and Myogenic Failure of the Bladder.
Seung Dai LIM ; Keung Won PARK ; Hee Kwan RIM ; Jong Sung KIM ; Jung Sik RIM
Korean Journal of Urology 2000;41(5):685-688
No abstract available.
Diabetes Insipidus, Nephrogenic*
;
Urinary Bladder*
3.Nephrogenic Diabetes Insipidus occurred in 2 Brother.
Jin Heon KIM ; Cheol Won PARK ; Bong Soo LEE ; Chang Soo RA
Journal of the Korean Pediatric Society 1983;26(9):916-921
No abstract available.
Diabetes Insipidus, Nephrogenic*
;
Humans
;
Siblings*
4.A case of nephrogenic diabetes insipidus due to vesicoureteral reflux.
Yong Bae SUH ; Jong Yul JEON ; Sung Ho CHA ; Byoung Soo CHO ; Chang Il AHN
Journal of the Korean Pediatric Society 1991;34(9):1299-1304
No abstract available.
Diabetes Insipidus, Nephrogenic*
;
Urinary Tract Infections
;
Vesico-Ureteral Reflux*
5.Nephrogenic Diabetes Insipidus Associated with Nonobstructive Dilation of the Urinary Tract and Voiding Difficulty.
Jeong Woo LEE ; Hwang CHOI ; Seung June OH
Korean Journal of Urology 2008;49(6):562-565
Nephrogenic diabetes insipidus(DI) is characterized by insensitivity of the distal nephron to vasopressin(ADH) and the inability to concentrate urine, which leads to excreting excessive quantities of urine. Upper tract dilation secondary to polyuria was previously shown to be associated with nephrogenic DI. We report here on 3 males with nephrogenic DI that caused voiding difficulty as well as massive nonobstructive dilation of the urinary tract.
Diabetes Insipidus
;
Diabetes Insipidus, Nephrogenic
;
Humans
;
Male
;
Nephrons
;
Polyuria
;
Urinary Tract
6.A Case of Congenital Nephrogenic Diabetes Insipidus with Bilateral Hydronephrosis and Hydroureter.
Yung Yi CHANG ; Hyung Uk KIM ; Hyung Du KIM ; Shin Young SHIN ; Jong Min LEE ; Hae Su KIM ; Suk Kyung KIM ; Byung Ki BANG
Korean Journal of Nephrology 2002;21(6):1026-1031
We describe a case of congenital nephrogenic diabetes insipidus with severe dilatation of bilateral urinary tracts without anatomical obstructions. Functional obstruction can be occurred when polyuria surpasses the transporting ability of urine in the urinary tract. The patient was admitted to our hospital due to decreased mentality developed after traffic accident. On radiologic study, bilateral hydronephrosis and hydroureter were noted. Because the patient excreted copious dilute urine, we performed water deprivation test and the result was consistent with nephrogenic diabetes insipidus. We are presenting this case in an attempt to describe strong association between congenital diabetes insipidus and nonobstructive hydronephrosis in which polyuria is responsible for the hydronephrosis.
Accidents, Traffic
;
Diabetes Insipidus
;
Diabetes Insipidus, Nephrogenic*
;
Dilatation
;
Humans
;
Hydronephrosis*
;
Polyuria
;
Urinary Tract
;
Water Deprivation
7.A Familial Case of Nephrogenic Diabetes Insipidus Associated with a Mutation of the AVPR2 Gene.
Wun Kon KIM ; Jin Seok LEE ; Tae Sun HA
Journal of the Korean Society of Pediatric Nephrology 2011;15(2):172-178
Nephrogenic diabetes insipidus is a rare genetic renal disease characterized by insensitivity of the kidney to the anti-diuretic effect of vasopressin in spite of elevated serum anti-diuretic hormone (ADH). Failure of the kidney to respond to ADH results in impaired osmoregulation and water reabsorption of the kidney, therefore, nephrogenic diabetes insipidus presents with a large amount of hypotonic polyuria, polydipsia, and dehydration. We report our experience of two familial cases of nephrogenic diabetes insipidus in brothers both having c.910+1delG in intron 2 of the AVPR2 gene with the brief review of related literatures.
Dehydration
;
Diabetes Insipidus, Nephrogenic
;
Humans
;
Introns
;
Kidney
;
Polydipsia
;
Polyuria
;
Siblings
;
Vasopressins
;
Water
;
Water-Electrolyte Balance
8.Dysregulation of Renal Cyclooxygenase-2 in Rats with Lithium-induced Nephrogenic Diabetes Insipidus.
Electrolytes & Blood Pressure 2007;5(2):68-74
This study aimed to examine whether the expression of major prostaglandin E2 (PGE2) synthesis enzyme, cyclooxygenase-2 (COX-2), is changed in the kidneys of the rats with lithium-induced nephrogenic diabetes insipidus (Li-NDI). Sprague- Dawley rats treated with lithium for 4 weeks were used as the NDI model and expression of renal COX-2 was determined by immunoblotting and immunohistochemistry. In Li-NDI where urine output was markedly increased and urine osmolality was significantly decreased, COX-2 expression in the inner medulla was decreased (28% of control), while it increased 18-fold in the cortex and outer medulla. Consistent with this, labeling intensity of COX-2 in macula densa region was increased, whereas it was decreased in the interstitial cells in the inner medulla, indicating a differential regulation of COX-2 between the cortex and inner medulla in Li-NDI. Accordingly, urinary PGE2 excretion was significantly increased in Li-NDI. In conclusion, there is a differential regulation of COX-2 between cortex and inner medulla in Li- NDI and urinary PGE2 excretion is increased in Li-NDI, possibly due to an increased renal production. This may suggest that increased renal production of PGE2 could play a role in modulating water reabsorption in the renal collecting duct in Li-NDI.
Animals
;
Aquaporins
;
Cyclooxygenase 2*
;
Diabetes Insipidus, Nephrogenic*
;
Dinoprostone
;
Immunoblotting
;
Immunohistochemistry
;
Kidney
;
Lithium
;
Osmolar Concentration
;
Prostaglandins
;
Rats*
9.A Case of Drug Induced Nephrogenic Diabetes Insipidus and Hyperprolactinemia in Schizophrenia Simultaneously.
Ho Yoel RYU ; Mi Young LEE ; Yeon LEE ; Jang Hyun KOH ; Mi Jin KIM ; Young Goo SHIN ; Choon Hee CHUNG
Journal of Korean Society of Endocrinology 2005;20(4):407-412
In schizophrenia, when treatment using antipsychotics fails, lithium, which is known as an antimanic drug, can also be administered. It is reported that 12~20% of patients taking lithium develop nephrogenic diabetes lactotrophs. Hyperprolactinemia is induced by typical antipsychotics, as they block the dopamine-2 receptors of latotrophs in the pituitary gland. Therefore, atypical antipsychotics for decreasing the side effect, such as hyperprolactinemia, can be used. However, hyperprolactinemia can be induced by risperidone, one of the atypical antipsychotics. Here, a case of drug induced nephrogenic diabetes insipidus and simultaneous hyperprolactinemia, which occurred in a patient with schizophrenia, is reported.
Antipsychotic Agents
;
Diabetes Insipidus, Nephrogenic*
;
Humans
;
Hyperprolactinemia*
;
Lactotrophs
;
Lithium
;
Pituitary Gland
;
Risperidone
;
Schizophrenia*
10.A Case of Congenital Partial Nephrogenic Diabetes Insipidus.
Eun Ha MO ; In Hye NAM ; Min Ja CHUNG ; Jae Hong YU
Journal of the Korean Pediatric Society 2002;45(7):902-905
The most common form of genetic nephrogenic diabetes insipidus(NDI), a rare inherited disorder, is congenital and is transmitted in an X-linked recessive mode. It is refractory to the antidiuretic effect of normal to moderately increased levels of plasma arginine vasopressin(AVP) but, in some cases, may respond to high levels of the hormone or its analogue, deamino-D-arginine vasopressin(DDAVP). X-linked congenital NDI has now been linked to over 128 different mutations in diverse coding regions of the AVP receptor 2(AVPR2) gene. The functional effects of these mutations vary from complete loss of responsiveness to a simple shift to the right in the dose response curve. We report a case of congenital partial NDI, with transversion of A to G at codon 280 of the AVPR2 gene, resulting in a subsequent change of amino acid from tyrosine to cysteine, and that has been effective with hydrochlorothiazide and high dose of DDAVP.
Antidiuretic Agents
;
Arginine
;
Clinical Coding
;
Codon
;
Cysteine
;
Deamino Arginine Vasopressin
;
Diabetes Insipidus, Nephrogenic*
;
Hydrochlorothiazide
;
Plasma
;
Tyrosine