Objective To explore the efficacy and safety of coflex interspinous dynamic fixation device implantation in the lumbar spinal stenosis. Methods Eighty-three patients with lumbar spinal stenosis were randomly divided into two groups, and 80 cases were followed up. Coflex group (38 patients) received coflex implantation,posterior lumbar interbody fusion (PLIF) group(42 patients) received PLIF treatment. Indicators of surgical trauma degree (operation time, blood loss volume, wound drainage volume within 48 hours, incision pain (VAS) score after surgery 3 days,postoperative ambulation time),indicators of clinical effect (waist and leg pain VAS scores,Japan Orthopaedic Association JOA score,Oswestry functional disability index ODI score),intervertebral space height and median sagittal diameter (MSO) were measured and compared between the two groups. Results In the Coflex group, the operation time, blood loss volume, wound drainage volume within 48 hours, incision pain (VAS) score after surgery 3 days,postoperative ambulation time were (104.3 ±9.5) min,(230. 7 ±29.6) ml,(110. 6 ±34. 5)ml,3. 2 ±1.3, (13. 6 ±2.0) d,which were significantly lower than those of (174. 6 ±24. 2) min,(536. 8 ±163.3) ml, (319. 2 ± 142. 8) ml,4. 8 ±2. 7, (15. 7 ±2. 6) d in the PLIF group(t= 16. 720,11. 380,8. 771,3. 320,4.018,Ps <0. 01). In the back and leg pain VAS score,JOA score,ODI score,intervertebral height and MSD,indicators after surgery were significantly improved than before surgery in both groups(Ps <0. 01). There were no significant difference before and after treatment 12 months in both groups (Ps >0. 05) on severe complications such as internal fixation loosening and spinous process fractures.Conclusion The two surgical methods both can effectively increase the foraminal area and intervertebral height to maintain the stability of the spinal posterior colum. However, Coflex interspinous dynamic fixation device implantation had more advantages,such as shorter operation time,less bleeding,less trauma,and early functional exercises.

Herpes simplex virus infection after excimer laser corneal refractive surgery often leads to serious complications,and the main reasons to induce the infection of herpes simplex virus are:irradiation of excimer laser and stimulation of corneal by surgery;long-term topical administration of steroids eye drops,or the interaction of all above factors.Once the herpetic keratitis appears,early and correct diagnosis and management are critical for rescuing the visual acuity.The laboratory assay methods,such as serum antibody,virus culture,corneal epithelial scraping,pathological examination,polymerase chain reaction ( PCR ),can be used for the assistance of diagnosis but each methods has their own limitation ; it is recognized that the multiplex PCR seem to become more sensitive.The primary treatment method for the infection of herpes simplex virus is to use the anti-virus drug topical or systemically after excimer laser corneal refractive keratectomy.the topical use of antivirus drugs in perioperation period for patients with history of herpetic keratitis can reduce the recurrence.This paper summarized the progress in clinical and experimental researches and review the etiology,diagnosis,treatment and prevention of herpetic keratitis following excimer laser corneal refractive surgery in recent years.

Congenital Talipes Equinovarus (CTEV), or club foot, is a common congenital orthopaedic abnormality of the foot. , which is easily diagnosed but difficult to treat perfectly. Controversy in terms of its etiology, classification and management continues to exist. Delayed initial treatment in patients with clubfoot has a strong correlation with a poor outcome. The purpose of this study was to review the factors that influence the outcome in patients who get delayed initial treatment at Hasan Sadikin General Hospital so that poor outcome can be prevented. We reviewed the medical records of 15 patients (23 feet) during the period from January 2009 to December 2013 and analysed various factors including gender, age at time of first treatment, type of disorder, the level of success of non-surgical therapy, parent education level, family income and accessibility to health care centre. CTEV was more common in girls in our patients who were in the 6-12 months age group. The most common type of CTEV was the flexible type. Treatment with serial casting produced good results in most patients. The majority of parents’ educational level was junior high school and had 2-5 million/month income. The accessibility of patients to health care centre was difficult.
Clubfoot

The social public signs system to exist mistake area on the understanding to the our country current medical treatment,the hospital usually uses this as to don't need the reason of responsibility,but sufferer then"life and death form" that it sees to sign as the compelled by circumstances,this makes to cure to suffer from an antinomy more for turn worse.Right know a medical treatment a signing system for alleviate to cure to suffer from an antinomy,set up diapason to cure to suffer from a relation to have great significance.

Objective: To study the relationship between effect of total saponins of Panax ginseng(TSPG) on expression of GM-CSF in human bone marrow stromal cells and modulation of human granulocytopoiesis and monocytopoiesis.Methods:The techniques of culture of hematopoietic progenitor cells and human bone marrow stromal cells in vitro,immunocytochemistry, nucleic acid in situ hybridization were used.Results:TSPG could markedly promote the colony formation of CFU-GM; human bone marrow stromal cells conditioned media prepared with TSPG could significantly enhance the proliferation and differentiation of CFU-GM,and expression of GM-CSF in protein and mRNA level in human bone marrow stromal cells induced by TSPG were much higher than those of the control group.Conclusion:TSPG may directly and/or indirectly promote stromal cells in hematopoietic inductive microenvironment to produce GM-CSF, which further prowote the proliferation and differentiation of human CFU-GM.

Objective To evaluate the therapeutic efficacy and complications of fluoroscopically guided double balloon dilation in the treatment of benign colorectal anastomotic strictures. Methods Under fluoroscopic guidance, 17 patients with benign colorectal anastomotic strictures underwent transanal double balloon dilation, including 13 patients underwent resection for malignant disease, and 4 for benign conditions. 16 out of 17 patients had difficulty or frequent defecation due to partial obstruction. The remaining one patient had the stricture detected by endoscopy and barium enema after total proctocolectomy and a temporary ileostomy for ulcerative colitis. Therapeutic efficacy and complications were evaluated in the follow-up visits. Results Seventeen patients received double balloon dilation in a single session. The diameter of double balloon catheter was arranged from 30 to 40 mm. Technical success achieved in all 17 patients with complete release (n = 12, 71%) or incomplete one (n = 5, 29%) and 100% improvement of symptoms was achieved in all patients, together with no major complications such as perforation or severe hemorrhage. During the mean follow-up of 23 months (range, 1 - 62 months), one patient (6%) developed a recurrent stricture and needed a second balloon dilation six months after the initial balloon dilation. Conclusions Fluoroscopically guided double balloon dilation is an effective and safe method for treating benign colorectal anastomotic strictures. (J Intervent Radiol, 2006, 15: 543-546)

Objectives:To determine the common allergens of patients with allergic rhinitis in Chongqing.Methods:A total of 738 cases who were diagnosed as allergic rhinitis by history and clinical presentation,underwent a skin prick test with 11 standardized aeroallergens and 10 ingestive allergens,and the important sensitizing allergens were assessed.Difference of skin prick test responses at various ages and with different gender was investigated.Results:The percent of patients with positive skin tests in inhalation allergens were as follows,dust(91.33%),acaridan(83.88%),prevemal pollen(68.97%),late spring pollen (66.67%),estivoautumnal pollen (61.25%),tobacco (58.94%) and cockroach (55.28%).Allergens in food were mainly prawn (62.47%) and crab(60.43%).Conclusion:The study shows that the dust,acaridan,prevemal pollen,late spring pollen and estivoautumnal pollen are the most important allergens in Chongqing region.

Overexpression of DNA methyltransferases(DNMTs)is observed in many tumors. Overexpressed DNMTs silence tumor suppressor genes by catalyzing the methylation of CpG islands within the promoter regions, and therefore promote the neoplastic transformation of normal cells. Highly elevated DNMT activities have been observed in cancers including gastrointestinal cancers, breast cancer, and lung cancer and have been associated with cancer development and prognosis. Drugs and targeted therapies that inhibit DNMT activities can reactivate methylated tumor suppressor genes, promote apoptosis, and thus inhibit tumor growth.

OBJECTIVE:To provide information about the brand positioning of pharmaceutical products for reference of Chinese pharmaceutical business.METHODS:We overviewed the implication and foundation of brand fixed position of phar?maceutical products and put forward the tactics of brand positioning of pharmaceutical products.RESULTS&CONCLU?SION:Under the conditions of sectionalized market and individulized consumption,nowadays,the existence and development of an enterprise directly depend on the success of brand positioning of its pharmaceutical products.

Objective To explore the effect of two traction ways of two-capsule compression on hemostasis. Methods Thirty-one hospitalized patients with compression hemostasis from February to January 2014 were set as the experiment group. Another thirty-two hospitalized patients from January 2012 to December 2012 were set as the control group. The control group was treated with traction of compression homeostasis in the traditional way, while the experiment group by the improved way. The two groups were compared in terms of the rate of effective compression hemostasis and the incidence of nasal membranes injury within 24 hours. Result The rate of the effective compression hemostasis within 24 h was not statistically different between the groups (P>0.05), but the incidence of nasal membranes injury was statistically different between them (P<0.05), the experiment group was less than that of the control group. Conclusion Improved traction of compression hemostasis is effective. It reduces the incidence of nasal membrane injury and pain so that it is worth clinical application.