1.Effect of two traction ways compression on hemostasis with three-way two-capsule
Modern Clinical Nursing 2015;(4):16-18
Objective To explore the effect of two traction ways of two-capsule compression on hemostasis. Methods Thirty-one hospitalized patients with compression hemostasis from February to January 2014 were set as the experiment group. Another thirty-two hospitalized patients from January 2012 to December 2012 were set as the control group. The control group was treated with traction of compression homeostasis in the traditional way, while the experiment group by the improved way. The two groups were compared in terms of the rate of effective compression hemostasis and the incidence of nasal membranes injury within 24 hours. Result The rate of the effective compression hemostasis within 24 h was not statistically different between the groups (P>0.05), but the incidence of nasal membranes injury was statistically different between them (P<0.05), the experiment group was less than that of the control group. Conclusion Improved traction of compression hemostasis is effective. It reduces the incidence of nasal membrane injury and pain so that it is worth clinical application.
2.Progress in tumor vascular normalization for anticancer therapy
Cancer Research and Clinic 2013;25(9):638-640
Blood vessels are indispensible for tumor growth and metastasis.Traditional antiangiogenic strategy reduce the density and the supply of tumor blood vessels.Recent studies have shown that antiangiogenic therapy has transient and insufficient efficacy.Blockage of blood and oxygen supplies creates a hypoxic and acidic microenvironment in the tumor tissues,which fosters tumor cells to become more aggressive and metastatic.Tumor vascular normalization may be an alternative approach to treat cancers,normalize the disorganized tumor vasculature,rather than disrupting or blocking them,thus reduce tumor hypoxia as well as increase the efficacy of chemotherapy,radiotherapy and immunotherapy.
3.Analysis of prognostic factors of young stroke patients with conventional treatment
Chinese Journal of Postgraduates of Medicine 2013;36(31):26-29
Objective To investigate the prognostic factors of young stroke patients with conventional treatment,and provide the basis for clinical diagnosis and treatment of stroke.Methods The clinical data of 72 cases of young stroke patients with conventional treatment were analyzed retrospectively.The prognostic factors were analyzed.Results In seventy-two cases of young stroke patients,18 cases of conventional treatment failed (25.00%,18/72).Univariate analysis showed that smoking,alcohol,underlying disease,dysphagia,barthel index (BI) score,U.S.national institutes of health stroke scale (NIHSS) score and Oxford handicap scale (OHS) score was closely related with the prognosis (P < 0.05 or < 0.01).Logistic analysis showed that the age,BI score,NIHSS score,OHS score and underlying diseases was the independent prognostic factor for young stroke patients.Eighteen cases who failed in conventional treatment fails accepted comprehensive rehabilitation treatment.Compared with that before treatment,1,3,6 months after treatment BI,NIHSS and OHS scores were significantly decreased (P < 0.05).Conclusions BI,NIHSS,OHS score and underlying diseases are the independent prognostic factor for young stroke patients.Surgery and postoperative comprehensive rehabilitation in young stroke patients who failed in conventional treatment can improve patient's outcomes and prognosis.
4.Clinical study of sevoflurane or propofol/remifentanil general anesthesia undergoing gynecological surgery
Chinese Journal of Postgraduates of Medicine 2014;37(18):9-11
Objective To study the effect of sevoflurane or propofol/remifentanil general anesthesia undergoing gynecological surgery.Methods A total of 80 patients scheduled for selected gynecological surgery were divided into sevoflurane group or propofol/remifentanil group by random digits table method and 40 cases in each group.The induction of anesthesia was conducted with midazolam,propofol,sulfentanil,and rocuronium.After tracheal intubation,anesthesia was maintained with sevoflurane in sevoflurane group,and with propofol/remifentanyl target-controlled infusion in propofol/remifentanil group.Bispectral index was monitored in each group,and which was maintained 40-60.Blood pressure and heart rate was observed.At the end of operation,all anesthetics were discontinued,and the time of consciousness recovery,tracheal extubation,orientation was recorded.The incidence of agitation,nausea and vomiting within 24 h after surgery and the use of rescue drugs such as epinephrine,atropine or urapidil was recorded.Results No statistically significant difference was observed with respect to the time of consciousness recovery,tracheal extubation,orientation between two groups (P > 0.05).The use of atropine and epinephrine in sevoflurane group was lower than that in propofol/remifentanil group [7.5%(3/40) vs.22.5%(9/40),20.0%(8/40) vs.32.5%(13/40)],and there was significant difference(P < 0.05),and the use of urapidil in sevoflurane group was higher than that in pmpofol/remifentanil group [22.5% (9/40) vs.2.5% (1/40)],and there was significant difference (P < 0.01).There was no statistically significant differences with respect to the incidence of agitation,nausea and vomiting within 24 h after surgery between two groups (P >0.05).Conclusion Propofol/remifcntanil and sevoflurane both provide satisfactory anesthesia for gynecological surgery.
5.Clinical observation of coflex interspinous dynamic internal fixation to treat degenerative lumbar spinal stenosis
Clinical Medicine of China 2011;27(6):631-634
Objective To explore the efficacy and safety of coflex interspinous dynamic fixation device implantation in the lumbar spinal stenosis. Methods Eighty-three patients with lumbar spinal stenosis were randomly divided into two groups, and 80 cases were followed up. Coflex group (38 patients) received coflex implantation,posterior lumbar interbody fusion (PLIF) group(42 patients) received PLIF treatment. Indicators of surgical trauma degree (operation time, blood loss volume, wound drainage volume within 48 hours, incision pain (VAS) score after surgery 3 days,postoperative ambulation time),indicators of clinical effect (waist and leg pain VAS scores,Japan Orthopaedic Association JOA score,Oswestry functional disability index ODI score),intervertebral space height and median sagittal diameter (MSO) were measured and compared between the two groups. Results In the Coflex group, the operation time, blood loss volume, wound drainage volume within 48 hours, incision pain (VAS) score after surgery 3 days,postoperative ambulation time were (104.3 ±9.5) min,(230. 7 ±29.6) ml,(110. 6 ±34. 5)ml,3. 2 ±1.3, (13. 6 ±2.0) d,which were significantly lower than those of (174. 6 ±24. 2) min,(536. 8 ±163.3) ml, (319. 2 ± 142. 8) ml,4. 8 ±2. 7, (15. 7 ±2. 6) d in the PLIF group(t= 16. 720,11. 380,8. 771,3. 320,4.018,Ps <0. 01). In the back and leg pain VAS score,JOA score,ODI score,intervertebral height and MSD,indicators after surgery were significantly improved than before surgery in both groups(Ps <0. 01). There were no significant difference before and after treatment 12 months in both groups (Ps >0. 05) on severe complications such as internal fixation loosening and spinous process fractures.Conclusion The two surgical methods both can effectively increase the foraminal area and intervertebral height to maintain the stability of the spinal posterior colum. However, Coflex interspinous dynamic fixation device implantation had more advantages,such as shorter operation time,less bleeding,less trauma,and early functional exercises.
6.The value of ultrasonography in diagnosing of benign and malignant ovarian teratomas
Chinese Journal of Ultrasonography 2001;10(5):265-266
Objective To evaluate the value of ultrasound in the diagnosis of benign and malignant ovarian teratomas.Methods The ultrasonographic imaging features of eighty-four cases of benign and malignant ovarian teratomas were viewed by two dimensional and color Doppler ultrasonography.Results Eighty-four cases were confirmed by pathology report that seventy-eight cases were ovarian teratomas.The accurate rate of ultrasound diagnosis was 92.9%(78/84).Among these cases,tumors which on the single side existed in sixty-nine cases (two tumors existed on the same side in two cases),and which on double sides existed in nine cases.Eighty-nine tumors were checked out all together.The ultrasonographic images of the ovarian teratomas displayed three types: mix(65 masses) , false solid (14 masses) and cyst (10 masses) type. Mix type was the major (occupied 65/89,73.0%). Multiplicate signs are shown in all of them. Malignant teratomas (3 masses,4 masses) not only appeared similar,but also more complex than the benign.Conclusions Ultrasonography is the first examination to be selected to diagnose teratoma of the ovary. Their ultrasonographic images are charaeteristic. If the images appears disorderly inside, the malignancy should be predicted with other clinical materials.
7.The detection of immune signs and their clinical significance in patients with JRA
Chinese Journal of Primary Medicine and Pharmacy 2008;15(6):974-975
Objective To explore the clinical value of detecting T cell subsets,immunoglobulin(Ig) ,erythro-cyte sedimentation rate(ESR),C-reactive protein(CRP) in patients with juvenile rheumatoid arthritis(JRA). Meth-ods T cell subsets(CD3+ , CD4+ , CD8+ , CD16+CD56+) was detected with flow cytometer, Ig, CRP with rate nephelome-try,ESR with Westergren's method in 40 cases of JRA,and other 40 normal children were served as normal control group. Results The level of CD3+ ,CD8+ ,CD16+CD56+ in the JRA group were lower,but CD4+ was higher than those in normal control group(P< 0.05 all) ;the level of IgA, IgG, IgM, ESR, CRP in the JRA group were all higher than those in the normal control group( P < 0.05 ). Conclusion There is an inflammation in patients with JRA, and when disease activity there is an immunological aberrance with cellular and humoral immunization.
8.Diagnosis and treatment of thyroid micro-carcinoma:a report of 52 cases
Chinese Journal of General Surgery 2000;0(11):-
Objective To analyze the clinical characteristics,diagnosis and treatment of thyroid micro-carcinoma.Methods The clinical data of 52 cases of thyroid micro-carcinoma operated from 2003 to 2008 were analyzed retrospectively.Results All of the 52 cases were confirmed as thyroid micro-carcinoma by postoperative pathologic exam;30 cases(57.7%) were discovered by intraoperative frozen section and 22 cases were not.Micro-calcification ratio on ultrasound was 35.19%.11 cases were diagnosed as malignant tumor on ultrasound scan preoperatively.Lobectomy of involved lobe with subtotal thyroidectomy of contra-lateral lobe was performed in 38 cases,3 cases of bilateral total thyroidectomy,3 cases of unilateral lobectomy and isthmectomy,5 cases of ipsilateral subtotal lobectomy and 3 cases of ipsilateral lobectomy with isthmectomy were performed.Combined central region lymph nodes dissection was adopted in 27 cases(positive 11/27,40.74%).Follow-up rate was 96.2%,with time ranging from 3 months to 5 years.No recurrence or mortality was discovered.Conclusions(1)B type ultrasound is the first choice for preoperative screening.(2) lpsilateral thyroid lobectomy with contralateral subtotal thyroidectomy combined with central region lymph node dissection is advocated.
9.DNA methyltransferases in cancer development, treatment and prognosis
Journal of International Oncology 2010;37(10):731-734
Overexpression of DNA methyltransferases(DNMTs)is observed in many tumors. Overexpressed DNMTs silence tumor suppressor genes by catalyzing the methylation of CpG islands within the promoter regions, and therefore promote the neoplastic transformation of normal cells. Highly elevated DNMT activities have been observed in cancers including gastrointestinal cancers, breast cancer, and lung cancer and have been associated with cancer development and prognosis. Drugs and targeted therapies that inhibit DNMT activities can reactivate methylated tumor suppressor genes, promote apoptosis, and thus inhibit tumor growth.
10.Suggestion on Use of Essential Medicine in Medical Institutions
China Pharmacy 1991;0(04):-
OBJECTIVE:To put forward advices to make sure the rational application of essential medicine in medical institutions.METHODS:The difficulties about the use of essential medicine in hospitals in China were analyzed to provide suggestions and measures for guaranteeing the rational use of essential medicine in hospitals.RESULTS&CONCLUSIONS:By reforming the mode of clinical payment,consummating the medical insurance system,making using rule of essential medicine,strictly managing medical institutions can ensure the appropriate use of essential medicine.