Objective To investigate the effects of placing medical collagen sponge on the wound surface for severe rupture of liver.Methods In 132 patients with severe hepatic trauma , 68 cases were randomly enrolled in collgan spong treatment group, in which the hepatic wound was treated with collagen sponge,while the 64cases in control group were treated with commonly used gelatin sponge. Results The therapeutic results of collagan spong group were better than those of control group in the hemostatic time [(19.65?1.28)min vs (34.3?1.2)min], hemorrhagic volume [(301.57?56.8)mL vs (642.3?61.8)mL], abdominal cavity drainage volume[(380.45?12.34)mL vs (693.2?219.4)mL], recovery time of hepatic tissue [(30.30?6.42)d vs (62.1?7.2)d], postoperation complications (re-bleeding , and hepatobiliary leakage) [11.5% and 3.0% vs 6.3% and 9.5%], and hospital time stay [(24.01?4.89)d vs (35.8?5.9)d] (all with P