1.Potential predictors for chemotherapeutic response and prognosis in epithelial ovarian, fallopian tube and primary peritoneal cancer patients treated with platinum-based chemotherapy
Dhammapoj JEERAKORNPASSAWAT ; Prapaporn SUPRASERT
Obstetrics & Gynecology Science 2020;63(1):55-63
3.38, PLR >210, CA125 >365, advanced stage, suboptimal disease, serous type, and ascites were significant predictive factors for platinum resistance. However, only NLR >3.38 and advanced stage were independent predictive factors with an adjusted odds ratio of 1.880 and 3.333, respectively. Regarding factors associated with poor survival outcomes, only PLR >210 and advanced stage were independent factors, with a hazard ratio of 1.578 and 3.994, respectively.CONCLUSION: High NLR and advanced stage were potential independent predictive factors for platinum resistance, whereas high PLR and advanced stage were potential independent predictive factors for poor survival outcomes.]]>
Ascites
;
Blood Platelets
;
Drug Therapy
;
Fallopian Tubes
;
Female
;
Humans
;
Lymphocytes
;
Medical Records
;
Multivariate Analysis
;
Neutrophils
;
Odds Ratio
;
Ovarian Neoplasms
;
Platinum
;
Prognosis
;
Retrospective Studies
;
ROC Curve