Objective To investigate the distribution properties of multifocal pattern visual evoked potential across visual field. Methods Multifocal pattern visual evoked potentials(VEP) of 14 normals were measured with VERIS Science TM 4.0. The visual stimuli were dart board 60 with patterns which consisted of 60 patches arranged in dart board configuration spanning a 26? visual field. The temporal modulation of each patch was controlled by a special type of pseudorandom sequence called binary m-sequence. The electrodes were placed at equal distances 2 cm inferior to and 2 cm superior to and straddling the inion . The first slice of the second order kernel for each stimulus patch was analysed. The 60 patches were grouped into several sectors. The summed responses of these sectors were analysed and compared. Results Compared with that of the lower hemifield, the polarity of the multifocal VEP of the upper hemifield was reverse, and the latency delayed, the response density decreased. With the eccentricity increased, the response density of the multifocal VEP decreased. The properties of the multifocal VEP of the horizontal sectors were different from that of the vertical sectors. Conclusion VEP of many locations within visual field could be recorded simultaneously in a short time with the method of mutifocal VEP. The multifocal VEP showed different properties in different sectors within visual field.

objective To observe the differences between four- and single-channel recording of normal multifocal visual evoked potential (mfVEP). Methods mfVEP of 35 health individuals (70 eyes) were detected by both four- and single-channel recording with VERIS apparatus. The root mean square (RMS) value of reactive amplitude was obtained from the results of the two kinds of recording. Each stimulated patch was analyzed to compare the variational degree of each patch between the two recording methods. Responases asymmetry coefficient (RAC) was introduced to evaluate the symmetry property between the two eyes in an individual. Results Compared with the single-channel recording,the responses of the stimulated patches of the four-channel recording were increased statistically, with most of the patches below the horizontal meridian and some of patches in the upper field, and there was distinct symmetry property between the two eyes in the same individual recorded by four-channel recording. Conclusion The four-channel recording is better than the single one and could be clinically applied and popularized.

Cytochrome P450 enzyme are an important enzyme family in drug metabolism. Human cytochrome P450 enzymes have been studied entensively about their polymorphism in recent years. polymorphism of CYP2C19 and CYP2D6 have been detected at both phenotypic and genotypic level, and their molecular mechanism have been studied entensively, however, the molecular mechanism of other enzymes for exzample CYP2C9,CYP1A1,CYP2E1 et al) is being discussed, though these enzymes possiblely exist polymorphism. The article summarizes the substrates of P450, molucular mechanism of polymorphism, and paticular reference to the effects of this variation on drug metabolism and susceptibility to chemically-induced diseases.

The binding of adriamycin to poly I:C, a double-stranded thetic homoribopolymor,and antitumor activity of adriamycin-Poly I:C complex were studied. Results showed that the affinity for adriamycin to poly I:C is no linear relationship. Adriamycin binding rate( % ) = 20.6 + 0.2268?Poly I:C(W)/adriamycin(W)? The increased therapeu-tic effect of the complex was comparable to that of the free and the Poly I:C alone on bearing Sl80 mice. In vitro cytotoxic effect of the complex is lower than free adriamycin following lh exposure. The complex is recommended for clinical therapeutic studies.

Flicker and photopic eletroretinogram(ERG)were recorded for 45 eyes of dry type of age-related macular degeneration(AMD)and 24 eyes of wet type of AMD respectively, the amplitude and phase of fundamental response compoment(30Hz)by discrete Fourier tranform(DFT)were analysed. The abnormality ratios of phases and amplitudes in fundamental responses, amplitudes of photopic white or red b-waves were 48.89%, 8.89%, 10.11% and 8.89% respectively. The visual acuities of 24 eyes were 1.0 or better, the abnormality ratios of phases were up to 37.50%. These suggest that the change of phases is a sensitive method for detecting the early abnormality of visual function in AMD. The abnormality ratios of phases and amplitudes in fundamental responses were 62.5% and 45.84% in wet type of AMD. The differences between dry type and wet type in amplitudes of fundamental responses and photopic b-waves were statistically significant(P

Objective To analyze the epidemiological trend and distribution of stroke mortality in residents of Tianjin, China. Methods The study was based on 102 718 died cases with stroke in Tianjin between 1999 and 2006. The death cause and the stroke typing were coded according to the ICD -9 and ICD -10. Standardized mortality rates were calculated for stroke and its subtypes, adjusted for age and sex according to the world standard population of the Year 2000. The age, sex and geographic distribution of the stroke and its subtype mortality were analyzed. Chi-square tests were used to determine the statistical significance of mortality trends and differences. Results Stroke mortality rate in Tianjin declined from 133.52 / 100 000 / year in 1999 to 102.52 / 100 000/year in 2006. Cerebral infarction accounted for more than 50% of stroke mortality. The stroke mortality rate for males (120.17 / 100 000 to 157.74 /100 000) was higher than that for females (84.87/100 000 to 109.31/100 000). Stroke mortality rates elevated with age (P

This study presents a fitting method for the intensity-response curve of electroretinogram. The data of b-wave amplitudes from 10 eyes with idiopathic macular hole and their contra-lateral contrast eye (normal) were analyzed. It was observed that the Rmax de creased significantly (P=0.013) in the eyes with idiopathic macular hole.

Purpose To observe the features of multi-focal electroretinogram (mERG) in Stargardt′s disease, and evaluate the validity of mERG on diagnosis of this disease. Methods mERG had been recorded in 7 cases (14 eyes) of Stargardt′s disease with VERIS 4.0,and the findings were compared with normal individuals. Results The mERG were remarkably abnormal in all cases of the disease, as the amplitudes of N 1 and P 1 waves were seriously decreased and the latencies were prolonged in all the 6 regions ( P

Objective To measure and compare the difference between the normal control and retinoschisis with multifocal electroretinography. Methods Nineteen cases (21 eyes) of normal control and 8 cases (15 eyes) of inherited retinoschisis were measured with VERIS Science TM 4.0. Three cases (6 eyes) of inherited retinoschisis were tested with Ganzfeld ERG. Results There was statistically significant difference of average response density and latencies in all 6 ring retinal regions between the normal control and retinoschisis. The topography of multifocal ERG showed that multifocal amplitude decreased with disappearing or decreasing of central peak amplitude in patients with retinoschisis. The P 1/N 1 ratio of the multifocal ERG average response densities in 6 ring retinal regions was different from the b/a ratio of the Ganzfeld ERG. Conclusion Each of the multifocal ERG and Ganzfeld ERG has its advantage in the diagnosis of the retinoschisis.

Objective To explore the changes of multifocal electroretinogram (mERG) before and after retinal detachment surgery and its clinical significance. Methods Eighteen patients suffered from rhegmatogenous retinal detachment underwent mERG before and after surgery using VERIS Science TM 4.0. The mERG at different area was compared between preoperative and postoperative surgery. Results Preoperatively, the latencies of a wave and b wave in detached area were statistically longer than in attached area ( t =4.541 and 6.784, P