Both thigns of the dogs were injured with 5.56mm M193 Bullets. The effects of the temporary cavity of high velocity missiles on the femoral arteries were studied. The displacement of the femoral artery was proportional to the size of the temporary cavity. The partial endothelial injury, Ices of intima, rupture of internal elastic membrane and thrombi were observed in the femoral arteries within 4 cm of residual track. The injuries in the leg with an exit wound were more severe than that in the leg with an entrance wound, the incidence of thrombosis in 24 and 172 hour groups was higher than in 6 hour group.

It is of great importance for surgery efficacy and avoidance of complications to reconstruct cervical curve, intervertebral height and cervical stability. Anterior cervical decompression includes discectomy and subtotal corpectomy. The former reconstruction comprises simple bone graft, bone graft with plating, cage implantation, cage with plating and total disc replacement.The latter comprises simple bone graft, bone graft with plating, titanium mesh cage with plating, conbinding cage and titanium mesh cage with plating. The common problem is loss of intervertebral height or nonunion occurring in a part of patients.Total disc replacement may preserve motion of affected levels but narrow indication. Based in the decompression, the best method should be choosen to reconstruct cervical stability and intervertebral height.

spleen(?)heart(?)muscle.The pharmacokinetics of PsD-044 in mice was fitted by an open three compartment model. The pharmacokinetic parameters calculated were shown to be essentially consistent with the determination of tissue distribution. It was also shown that PsD-044 can't pass through blood-brain barrier.

[Objective]To discuss surgical approaches,results and complications of ossification of posterior longitudinal ligament(OPLL)of cervical spine.[Method]The clinic data of 48 patients from 2000 with cervical OPLL were reviewed and analyzed.Eighteen of them were decompressed from an anterior approach and 30 from a posterior approach.The improvement rate according to JOA scoring system were evaluated,some relevant imaging examination data including X-rays,CT and MRI were also measured,which were taken preand post-operatively.Surgical complications were also recorded.[Result]Of 48 patients,23 had cervical stenosis,the mean occupancy rate was 41.4%,and 19 had the abnormal signal in spinal cord.The mean postoperative improvement rate was 68.3% in patients treated by anterior decompression and 51.3% in those treated by posterior decompression.There were 2 patients with dural tear,5 with segmental nerve root palsy and 2 with hematoma after operation.[Conclusion]Suitable operation methods should be chosen according to the location,extent and occupancy ratio of OPLL,which is important for avoiding complications and improving surgical results.

[Objective]To appraise the clinical effect of the cervical interbody fusion with PEEK cages after anterior decompression through disc space.[Method]Forty-five patients with cervical spondylosis or disc herniation were treated by using PEEK cages after anterior decompression.X-ray films were taken after operation to observe the stability,fusion rate and intervertebral disc height of the segments.The neural function was evaluated by JOA scoring system.[Result]All patients were followed up from 6 to 12 months.The operated segments were stable and height of disc space was reconstructed.Solid fusion was observed 6 months after operation.The improvement rate of neural function was 45%~100%,with an average of 84%.[Conclusion]The PEEK cage has the advantages of excellent biocompatibility,lower elastic modulus and radiolucence,which helps to reconstruct and maintain the intervertebral disc height and cervical lordosis effectively with satisfactory fusion rate.

[Objective] To discuss the prognostic factors for cervical OPLL treated by anterior decompression.[Method]A total of 48 patients with cervical OPLL,who underwent anterior decompression,were followed up for 1～4 years,with an average of 2.1 years.The patients were classified into a good-prognosis group and a poor-prognosis group according to the JOA neruologic scoring system.Age,sex,JOA score,duration of symptoms,diabetes mellitus,Pavolv ratio,occupying rate,type of ossification,CT double-layer sign,hyperintense areas,level of segments,and treatment of ossification were testified using multiple logistic regression analysis.[Result]Treatment of ossification was the only statistically significant factor predicting clinical results in this study.[Conclusion]It is the most important to resect the ossification and decompress the spinal cord thoroughly in the process of antarior decompression for cervical OPLL.

[Objective]To assess the accuracies and feasibility of computer assisted navigation technique in scoliosis surgery.[Method]In clinical study,5 cases of scoliosis operations assisted by computer navigation technique(Group 1)and 5 cases of scoliosis operations assisted by anatomy and X-ray fluoroscopy(Group 2)were reviewed.The accuracies of screw placement were evaluated by postoperative CT scan.[Result]There were altogether 114 screws inserted in 10 cases.49 screws inserted with CTbased computer assisted navigation system,91.8% excellent,8.2% good.42 screws inserted with anatomy and X ray fluoroscopy,57.1% excellent,23.8 % good,19.1% bad.[Conclusion]CT-based computer assisted navigation system enhances accuracies and further improves the safety of adolescent scoliosis surgery,CT-based navigation method is better than the anatomy and X-ray fluoroscopy methods.

Objective To study the effects of Qi Jia Zhen Wu Decoction (QJZWD), a traditional Chinese medicinal decoction, in combination with corticosteroid on the apoptosis and expression of Fas, FasL in peripheral blood lymphocytes (PBLs) from patients with systemic lupus erythematosus (SLE). Methods QJZWD containing sera were collected from rabbits. PBLs isolated from 19 SLE patients and 10 healthy controls were incubated with QJZWD containing sera (20%, 10%, 5%), dexamethasone (0.001 mol/L), and QJZWD containing sera (20%, 10%, 5%) in combination with dexamethasone. Apoptosis and expression of Fas and FasL of PBL were detected by flow cytometry. Results ①Apoptosis of PBLs cultured in vitro was significantly higher in SLE patients than that in healthy controls (P 0.05). ②Significantly decreased apoptosis was found in PBLs cultured with herb-containing sera (10%, 20%) compared to that without herb-containing sera (P

[Objective]To discuss the diagnosis,treatments and the outcome of anterior spinal artery syndrome induced by cervical disc herniation.[Methods]Eighteen patients(male 13,female 5,average age 35.6 years old) were diagnozed to experience cervical disc herniation by MRI scans.All the patients presented with severe motor paralysis with loss of sensation to pain and temperature but sparing of proprioceptive sensation,which was just like the clinical features of anterior spinal artery syndrome.The average preoperative JOA score was 7.6 points,ranged from 4 to 10.Anterior cervical decompression with fusion was performed on 17 patients within 15 days.Spinal canal occupation was found in 1 case.Posterior approach treatment was not effective and anterior approach decompression was performed 1 year later.[Results]All these patients were followed up for an average of 15 months(12 to 24 months).Seventeen patients had a good outcome.The postoperative JOA score ranged from 7 to 15 points(13.4 in average) and the mean JOA recovery ratio was 61.7%.All the patients recovered with no complication.[Conclusion]A herniated cervical disc can compress the spinal anterior artery and involve with anterior spinal artery syndrome.It can be final diagnozed with clinical features and MRI scans.The outcome is satisfactory when an early and complete anterior decompression with fusion is performed.

BACKGROUND: Anterior subtotal vertebrectomy and fusion using titanium mesh cage (TMC) is an effective surgical treatment for cervical spondylosis, while TMC subsidence usually occurs. The risk factors for TMC subsidence and its effect on the treatment outcomes remain controversial. OBJECTIVE: To investigate the TMC subsidence after anterior subtotal vertebrectomy and TMC fusion and its effect on the treatment outcomes, thereby understanding the underlying mechanism and related risk factors. METHODS: Clinical data of 34 patients undergoing anterior subtotal vertebrectomy and TMC fusion in the Second Department of Spine, Shanghai Changzheng Hospital Affiliated to the Second Military Medical University from March to September 2015 were analyzed retrospectively. After 12-month follow-up, the height of the fused segments was measured, and the neurologic outcomes were evaluated using the Japanese Orthopedic Association scores. The loss of the fused segments subsided more than 3 mm compared with that at 1 day postoperatively was considered as TMC subsidence, and all patients were allotted to TMC subsidence and control (without TMC subsidence) groups.RESULTS AND CONCLUSION: (1) Totally 19 patients (56%) experienced TMC subsidence that occurred in postoperative (6.00±3.73) months averagely. (2) No significant differences were found in the age, sex or the level of fused segments between two groups (P=0.731, 0.672, 0.053). (3) The Japanese Orthopedic Association recovery ratio in the control group was significantly higher than that in the TMC subsidence group (P=0.01), suggesting that TMC subsidence might be correlated with the poor improvement of neurologic function after surgery. (4) To conclude, TMC subsidence is a common complication after anterior subtotal vertebrectomy, which does harm to the treatment outcomes.Moreover, age, sex or the level of fused segments are not independent risk factors for TMC subsidence.