1.A Case of Focal Nodular Hyperplasia of the Liver.
Cheol Su LIM ; Su Tek LEE ; Dae Ghon KIM ; Deuk Soo AHN ; Lee Chul YU ; Baik Hwan CHO
The Korean Journal of Hepatology 1997;3(4):337-343
Focal nodular hyperplasia (FNH) is a rare, benign hepatic tumor which was usually discovered incidentally by imaging procedure performed for some other reasons. FNH is typically asymptomatic and, it seldom bleeds. There is no evidence to support any relation with primary liver cancer. Accordingly, the preferred management is conservative, and excision is reserved for large symptomatic and complicated lesion, or when the diagnosis remains uncertain. Although many cases of FNH has been described to date in the other countries, only four cases of FNH has been reported in Korean literature. In the present report we describe a 7 cm sized asymptomatic lesion of FNH in a 23-year-old woman, that was disclosed by various kinds of imaging procedure. The left lateral segmentectomy was performed. The mass was firm and showed areas of localized growth of mature hepatocytes and septal fibrosis accompanied with marginal ductal proliferation, consistent with FNH. It also displayed an incomplete stellate architectual configration consisted of a central fibrous scar.
Cicatrix
;
Diagnosis
;
Female
;
Fibrosis
;
Focal Nodular Hyperplasia*
;
Hepatocytes
;
Humans
;
Liver Neoplasms
;
Liver*
;
Mastectomy, Segmental
;
Young Adult
2.A Case of Familial Adenomatous Polyposis (FAP) with A Large Sentinel Polyp.
Dae Ghon KIM ; Byung Hyun RHEE ; Seong Hee LIM ; Wan Hee YOO ; Jae Yong KWAK ; Deuk Su AHN ; Jong Hun KIM ; Dong Geun LEE
Korean Journal of Gastrointestinal Endoscopy 1995;15(4):775-782
Familial adenomatous polyposis(FAP) is a rare hereditary disorder characterized by the development of hundreds to thounds polyps throughout the colon and rectum. Moreover, several extracolonic manifestations are seen. Recently, this disease is recognized as a adenomatous polyposis syndrome which can involve the entire astrointestinal tract. Several reports have demonstrated a high incidence of gastroduodenal polyps in patients with familial adenomatous polyposis. These colon polyps can be eventually developed as colon cancer, if not be treated. So early diagnosis is needed and prophylactic surgery should be erformed. We experienced a case of familial adenomatous polyposis with a large sentinel polyp on the sigmoid colon, presenting hematochezia and mucoid diarrhea. He was early treated before progression to carcinoma by total colectomy, rectal mucosectomy and J pouch ileoanal anastomosis.
Adenomatous Polyposis Coli*
;
Colectomy
;
Colon
;
Colon, Sigmoid
;
Colonic Neoplasms
;
Colonic Pouches
;
Diarrhea
;
Early Diagnosis
;
Gastrointestinal Hemorrhage
;
Humans
;
Incidence
;
Polyps*
;
Rectum
3.Subacute Ischemic Colitis Developed after Severe Watery Diarrhea.
Seung Ok LEE ; Seung Hyun LEE ; Gwang Hun KIM ; Nam Su KIM ; Jeong Ki CHOI ; Jeong Kwon KIM ; Su Teik LEE ; Dai Gon KIM ; Deuk Su AHN
Korean Journal of Gastrointestinal Endoscopy 1999;19(2):306-312
Ischemic colitis represents most common form of gastrointestinal ischemia, usually developed in elderly or debilitated patient with a variety of underlying medical problems. The presumed etiologies are numerous. It usually presents as an acute abdominal illness with bloody diarrhea. Subacute ischemic colitis in healthy adults develops spontaneously in the absence of major vasculature occlusion, and the original insult precipitating the ischemic event usually cannot be established. Diagnosis is based on the clinical symptom, barium study, colonoscopic and histopathologic findings. Therapy and outcome are depen-dent on the severity of disease. It usually requires only medical management and is asso-ciated a good prognosis. We report a case of subacute ischemic colitis in healthy adults developed after severe watery diarrhea with literatures.
Adult
;
Aged
;
Barium
;
Colitis, Ischemic*
;
Colon
;
Diagnosis
;
Diarrhea*
;
Humans
;
Ischemia
;
Prognosis
4.Quantitative Rapid Urease Test in Helicobacter Pylori Infection.
Seung Ok LEE ; Byoung Sik MUN ; Cheol Su LIM ; Seong Ki MUN ; Dae Ghon KIM ; Deuk Soo AHN ; Ho LEE ; Dong Keun LEE
Korean Journal of Gastrointestinal Endoscopy 1998;18(3):303-311
BACKGROUND/AIMS: The principle of the rapid urease test is the assessment of the color change of the pH indicator, phenol red, by ammonium and bicarbonate ions which were produced by the urease. We modified a conventional rapid urease test, and quantified H. pylori infection by measuring the change of spectrophotometric absorbance. METHODS: 202 patients with upper gastrointestinal symptoms were endoscopically examined and three biopsies were performed in each antrum and fundus. Two biopsy specimens were stained with Giemsa and scored from 0 to 4 according to the distribution of bacteria by the Wyatt method. Another specimen was used for the quantitative rapid urease test. The tissue was incubated in a cuvette containing 10% of urea solution and phenol red at 37C. We measured optical densities in 550 nm at 5 min, 10 min, 15 min, 30 min, 1 hrs, 2 hrs, 4 hrs and 24 hrs time points.
Ammonium Compounds
;
Bacteria
;
Bicarbonates
;
Biopsy
;
Helicobacter pylori*
;
Helicobacter*
;
Humans
;
Hydrogen-Ion Concentration
;
Phenolsulfonphthalein
;
Urea
;
Urease*
5.Neuronal Phenotypes and Gene Expression Profiles of the Human Adipose Tissue-Derived Stromal Cells in the Neuronal Induction.
Su Kyung SHIM ; Deuk Young OH ; Young Joon JUN ; Paik Kwon LEE ; Sang Tae AHN ; Jong Won RHIE
Journal of the Korean Society of Plastic and Reconstructive Surgeons 2007;34(1):1-7
PURPOSE: Human adipose tissue-derived stromal cells(hADSCs) can be expanded in vitro and induced to differentiate into multiple mesenchymal cell types. In this study we have examined various neuronal phenotypes and gene expression profiles of the hADSCs in the neuronal induction. METHODS: The hADSCs were isolated from human adipose tissue and they were characterized by the flow cytometry analysis using CD13, CD29, CD34, CD45, CD49d, CD90, CD105 and HLA-DR cell surface markers. We differentiated the hADSCs into the neuronal lineage by using chemical induction medium and observed the cells with contrast microscopy. The immunocytochemistry and western blotting were performed using the NSE, NeuN, Trk-A, Vimentin, N-CAM, S-100 and beta-Tubulin III antibodies. RESULTS: The hADSCs were positive for CD13(90.3+/-4%), CD29(98.9+/-0.7%), CD49d(13.6+/-6%), CD90 (99.4+/-0.1%), CD105(96%+/-2.8%) but negative for CD34, CD45 and HLA-DR. The untreated cultures of hADSCs predominately consisted of spindle shaped cells and a few large, flat cells. Three hours after the addition of induction medium, the hADSCs had changed morphology and adopted neuronal-like phenotypes. The result of immunocytochemistry and western blotting showed that NSE, NeuN, Trk-A, Vimentin, N-CAM, S- 100 and beta-Tubulin III were expressed. However, NSE, NeuN, Vimentin were weakly expressed in the control. CONCLUSION: Theses results indicate that hADSCs have the capabillity of differentiating into neuronal lineage in a specialized culture medium. hADSCs may be useful in the treatment of a wide variety of neurological disorders.
Adipose Tissue
;
Antibodies
;
Blotting, Western
;
Flow Cytometry
;
Gene Expression*
;
HLA-DR Antigens
;
Humans*
;
Immunohistochemistry
;
Microscopy
;
Nervous System Diseases
;
Neurons*
;
Phenotype*
;
Stromal Cells*
;
Transcriptome*
;
Tubulin
;
Vimentin
6.The change of gastric antral mucin expression after Helicobacter pylori eradication.
Myung Sin MA ; Jin Su HWANG ; Sung Il NA ; Kil Hong LEE ; Jeong Ki CHOI ; Seung Ok LEE ; Myoung Jae KANG ; Dae Ghon KIM ; Deuk Soo AHN ; Soo Teik LEE
Korean Journal of Medicine 2003;64(1):21-27
BACKGROUND: Helicobacter pylori colonizes the gastric surface epithelium and the mucus gel layer. It has been known that H. pylori infection decreased the gastric mucin expression. The aim of this study was to determine the effect of H. pylori eradication on mucin expression (MUC5AC, MUC6 and MUC1) in the gastric epithelium. METHODS: This study included 20 patients positive for H. pylori whom successful eradication was performed between March 1998 and December 1999. H. pylori status was determined by histology, rapid urase test and urea breath test. Gastric antral biopsy specimens were examined by immunohistochemistry for mucin (MUC5AC, MUC6 and MUC1) expression. The distribution of epithelial cells expressing MUC5AC was calculated at two sites (surface mucous cells, pyloric glands). Two scores system (weak-strong) was used to assess staining intensity. RESULTS: There was a gradient of MUC5AC expression, higher to lower from the surface to the glands. Increased MUC5AC expression in the surface mucous cell (p=0.013) and in the glands (p=0.008) was found after H. pylori eradication. MUC6 and MUC1 distribution was not changed after H. pylori eradication. CONCLUSION: MUC5AC expression was increased after H. pylori eradication. These results suggest that MUC5AC may relate in the pathogenesis of H. pylori.
Biopsy
;
Breath Tests
;
Colon
;
Epithelial Cells
;
Epithelium
;
Gastric Mucins
;
Helicobacter pylori*
;
Helicobacter*
;
Humans
;
Immunohistochemistry
;
Mucins*
;
Mucus
;
Urea
7.Status and trends in epidemiologic characteristics of diabetic end-stage renal disease: an analysis of the 2021 Korean Renal Data System
Kyeong Min KIM ; Seon A JEONG ; Tae Hyun BAN ; Yu Ah HONG ; Seun Deuk HWANG ; Sun Ryoung CHOI ; Hajeong LEE ; Ji Hyun KIM ; Su Hyun KIM ; Tae Hee KIM ; Ho-Seok KOO ; Chang-Yun YOON ; Kiwon KIM ; Seon Ho AHN ; Yong Kyun KIM ; Hye Eun YOON
Kidney Research and Clinical Practice 2024;43(1):20-32
Korean Renal Data System (KORDS) is a nationwide end-stage renal disease (ESRD) registry database operated by the Korean Society of Nephrology (KSN). Diabetes mellitus is currently the leading cause of ESRD in Korea; this article provides an update on the trends and characteristics of diabetic ESRD patients. The KORDS Committee of KSN collects data on dialysis centers and patients through an online registry program. Here, we analyzed the status and trends in characteristics of diabetic chronic kidney disease stage 5D (CKD 5D) patients using data from 2001 to 2021. In 2021, the dialysis adequacy of hemodialysis (HD) was lower in diabetic CKD 5D patients than in nondiabetic CKD 5D patients, while that of peritoneal dialysis (PD) was similar. Diabetic CKD 5D patients had a higher proportion of cardiac and vascular diseases and were more frequently admitted to hospitals than nondiabetic CKD 5D patients, and the leading cause of death was cardiac disease. From 2001 to 2020, diabetic CKD 5D patients had a higher mortality rate than nondiabetic CKD 5D patients, but in 2021 this trend was reversed. Diabetic PD patients had the highest mortality rate over 20 years. The mortality rate of diabetic HD patients was higher than that of nondiabetic HD patients until 2019 but became lower starting in 2020. There was a decreasing trend in mortality rate in diabetic CKD 5D patients, but cardiac and vascular diseases were still prevalent in diabetic CKD 5D patients with frequent admissions to hospitals. More specialized care is needed to improve the clinical outcomes of diabetic CKD 5D patients.
8.Trends in clinical outcomes of older hemodialysis patients: data from the 2023 Korean Renal Data System (KORDS)
Hyunglae KIM ; Seon A JEONG ; Kyeong Min KIM ; Sun Deuk HWANG ; Sun Ryoung CHOI ; Hajeong LEE ; Ji Hyun KIM ; Su Hyun KIM ; Tae Hee KIM ; Ho-Seok KOO ; Chang-Yun YOON ; Kiwon KIM ; Seon Ho AHN ; Hye Eun YOON ; Yong Kyun KIM ; Tae Hyun BAN ; Yu Ah HONG
Kidney Research and Clinical Practice 2024;43(3):263-273
With an increasing aging population, the mean age of patients with end-stage kidney disease (ESKD) is globally increasing. However, the current clinical status of elderly patients undergoing hemodialysis (HD) is rarely reported in Korea. The current study analyzed the clinical features and trends of older patients undergoing HD from the Korean Renal Data System (KORDS) database. The patients were divided into three groups according to age: <65 years (the young group), n = 50,591 (35.9%); 65–74 years (the younger-old group), n = 37,525 (26.6%); and ≥75 years (the older-old group), n = 52,856 (37.5%). The proportion of older-old group undergoing HD significantly increased in incidence and decreased in prevalence from 2013 to 2022. The median levels of hemoglobin, serum creatinine, albumin, calcium, phosphorus, and intact parathyroid hormone significantly decreased in the older-old group. The proportions of arteriovenous fistula creation and left forearm placement showed decreased trends with age. Although the utilization of low surface area dialyzers increased with age, the dialysis adequacy, including urea reduction ratio and Kt/V was within acceptable range in the older-old group on HD. Over the past 20 years, the mortality rate in the older-old group has increased, with cardiovascular diseases decreasing and infectious diseases increasing. The incidence of elderly patients undergoing HD has increased over time, but the high mortality of the older-old group needs to be solved. Therefore, it is imperative to develop holistic strategies based on age and individual needs for patients with ESKD.
9.The Clinical and Histopathological Study of Ota's Nevus.
Seung Hyun CHUN ; Sanghoon LEE ; Hana PARK ; Su Young JHUN ; In Bum SOHN ; Hak Yong KIM ; Eung Ho CHOI ; Sang Min HWANG ; Seung Hun LEE ; Joong Gie KIM ; Seong Jun SEO ; Joo Heung LEE ; Hyun CHUNG ; Sang Won KIM ; Jeong Deuk LEE ; Young Min PARK ; Hyung Ok KIM ; Bo Kyung KOH ; Il Hwan KIM ; Soo Nam KIM ; Seok Jong LEE ; You Chan KIM ; Mi Woo LEE ; Jai Kyoung KOH ; Kwang Ho KIM ; Sang Tae KIM ; Kee Suck SUH ; Sung Ku AHN
Korean Journal of Dermatology 2004;42(3):272-280
BACKGROUND: Ota's nevus, characterized by the presence of melanocytes in the dermis, has been familiar among dermatologists, but the etiology, the pathophysiology, the clinical and histological classification are not entirely clear. To understand and elucidate them, more clinical studies and researches are necessary. OBJECT: The aim of this study was to document the clinical and histopathological features of Ota's nevus. METHODS: We examined 299 patients with Ota's nevus who visited the dermatology clinic in Korea from February 1993 to August 2003. Among them, 188 patients were biopsied. All the specimens were stained with hematoxylin and eosin. We examined the age & sex distribution, age of onset, seasonal variation, associated skin diseases, aggravating factors and color. We clinically classified Ota's nevus into 4 types according to Tanino's classification and histologically into 5 types based on the pattern of pigmentation. RESULTS: 1. The ratio of male and female was 1: 3. 2. The peak age of onset was at birth (28.4%) and puberty (24.8%). 3. Seasonal variation was observed with distinct aggravation in the summer (60%). 4. The associated diseases were 9 cases of persistent mongolian spot, 6 cases of nevus flameus, 4 cases of blue nevus, 3 cases of vitiligo, 3 cases of nevus of Ito, 2 cases of atopic dermatitis, 2 cases of psoriasis, 2 cases of cafe au late macules and 2 cases of contact dermatitis. 5. The aggravating factors were sunlight (35.8%), emotional stress (21.0%), menstruation (12.6%), cold exposure (9.5%), pregnancy (9.5%), fatigue (9.5%) and chemical agents (2.1%). 6. The color of lesions were blue black (36.8%), brown (34.8%), dark brown (16.1%) and slate (11.0%). 7. All cases were classified according to Tanino's METHODS: type Ia (23.1%), type Ib (20.1%), type II (26.7%), type III (9.4%), type IV (20.7%). 8. The histological subtypes of Ota's nevus were classified as: the superficial type (35.6%); the middermis type (5.9%), the superficial-middermis type (18.6%); the mid-lower dermis type (2.7%); the diffuse type was composed of the superficial dominant type (19.7%), the middermis dominant type (4.8%), the dispersed (true diffuse) type (12.2%) and the deep dominant type (0.5%). 9. In the relation between histological types and the color of the lesion: the superficial type had 31 cases of brown color, 15 cases of blue black color, 11 cases of dark brown color and 9 cases of slate color; the middermis type had 6 cases of blue black color and 2 cases of dark brown color, query number of cases of slate color; the superficial-middermis type had 12 cases of blue black color, 10 cases of dark brown color, 7 cases of brown color and 6 cases of slate color: the mid-lower dermis type had 3 cases of blue black color; for the diffuse type, the superficial dominant type had 13 cases of brown color, query number of cases of blue black color and 7 cases of dark brown color; the mid-dermis dominant type had 4 cases of brown color, query number of cases of dark brown color, the dispersed type had 14 cases of blue black color and 5 cases of brown color; the deep dominant type had 1 case of blue black color. CONCLUSION: The histological reclassification of Ota's nevus may be very useful in making a therapeutic prognosis of the disease.
Adolescent
;
Age of Onset
;
Classification
;
Dermatitis, Atopic
;
Dermatitis, Contact
;
Dermatology
;
Dermis
;
Eosine Yellowish-(YS)
;
Fatigue
;
Female
;
Hematoxylin
;
Humans
;
Korea
;
Male
;
Melanocytes
;
Menstruation
;
Mongolian Spot
;
Nevus
;
Nevus of Ota*
;
Nevus, Blue
;
Parturition
;
Pigmentation
;
Pregnancy
;
Prognosis
;
Psoriasis
;
Puberty
;
Seasons
;
Sex Distribution
;
Skin Diseases
;
Stress, Psychological
;
Sunlight
;
Vitiligo