PURPOSE: Lower urinary tract symptoms (LUTS) usually co-exist with erectile dysfunction. Although the mechanisms for this are still unknown, there seems to be a correlation between the two diseases. We evaluated the effect of lower urinary tract symptoms on the erectile function and the frequency of sexual intercourse. MATERIALS AND METHODS: 1,216 patients, who visited our hospital due to LUTS from January 2000 to April 2006, were evaluated for their erectile function with using International Index of Erectile Function-Erectile Function (IIEF-EF) domain score, frequency of sexual intercourse per month during the last 3 months, prostate volume, International Prostate Symptom Score (IPSS) and quality of life (QoL). The patients were divided into five groups according to age: younger than 40, 40-49, 50-59, 60-69 and older than 70. The patients were again divided into three group according to IPSS: mild (0-7), moderate (8-19) and severe (20-35). Multiple regression analysis and two-way ANOVA were used to analyze the data. RESULTS: 772 patients were eligible for the analysis. The mean patient age was 53.6+/-12.6 years, the mean IPSS was 13.8 9.2 and the mean IIEF-EF score was 17.0+/-9.4. Among the age and LUTS parameters, only age and IPSS had significant effect on the erectile function (p<0.01). The IIEF-EF domain score showed significant differences among the each age group and also among the age-adjusted IPSS groups (p<0.01, p=0.023). The frequency of sexual intercourse per month during the last 3 months showed a significant difference among the each age group (p<0.01). CONCLUSIONS: Erectile function declines with the age-adjusted LUTS severity as well as with age. The frequency of sexual intercourse per month during the last 3 months declines with age, but not with the age-adjusted LUTS severity.
Coitus* ; Erectile Dysfunction ; Humans ; Lower Urinary Tract Symptoms* ; Male ; Prostate ; Quality of Life ; Sexual Behavior ; Urinary Tract

PURPOSE: To report the method of anatomical reduction and its maintenance by percutaneous wiring reduction in minimally invasive plate osteosynthesis for distal tibial fractures. MATERIALS AND METHODS: 17 cases that were diagnosed oblique, spiral or transverse fracture of distal tibia from August 2007 to February 2010 and were able to anatomically reduce by the method of percutanous wiring reduction in minimally invasive plate osteosynthesis were included in this study. Mean age was 50, and mean follow up period was 18 months. We investigated the period until bone union was achieved, degree of angulation angle, and complications. For postoperative evaluation, Olerud and Molander ankle score and VAS pain score in daily living were checked. RESULTS: The mean varus/valgus angulation after bone union on AP radiograph was 0.9 degrees and the mean anterior/posterior angulation on lateral radiograph was 2.0 degrees The mean Olerud and Molander ankle score was 89.4, and mean pain score due to walk adjacent to metal plate was 0 points. CONCLUSION: By the method of percutaneous wiring reduction in distal tibial fracture, anatomical reduction is easily acquired, and only by wire itself, reduction could be maintained, so that without additional manual reduction, plate could be easily fixed.
Animals ; Ankle ; Follow-Up Studies ; Tibia ; Tibial Fractures

Neoplasms of the prostate usually metastasize to pelvic lymph nodes or bone, or directly invade the adjacent pelvic organs. Ureteral metastasis of a prostatic carcinoma, without ascending spread along the ureter, is very rare, with only a few having been reported from autopsy series. Herein, the case of a prostatic carcinoma, distantly metastasized to the unilateral ureter, is reported.
Autopsy ; Lymph Nodes ; Neoplasm Metastasis ; Prostate* ; Prostatic Neoplasms* ; Ureter*

Diffuse neonatal hemangiomatosis is a disease often with a fatal outcome, characterized by widespread capillary hemangiomias of the skin and visceral organs. A 6-month-old-girl was diagnosed to have diffuse neonatal hemangiomatosis by her multiple hemangiomas on the skin, liver, brain, lung and oral mucosa. She was treated with prednisolone 1.5-2mg/kg/day for 9 months and combined interferon alfa-2a 3 million unit/m2/day for 5months. During the treatment the number and size of hemangiomas were markedly reduced
Brain ; Capillaries ; Fatal Outcome ; Hemangioma ; Interferon-alpha* ; Interferons* ; Liver ; Lung ; Mouth Mucosa ; Prednisolone* ; Skin

No abstract available.
Listeria* ; Meningitis, Listeria* ; Transplantation*

Traumatic hip fracture-dislocations are associated with chondral and labral pathology as well as loose bodies that can be incarcerated in the hip joint. Incarceration, such as interposed labrum between acetabulum and femoral head that is not readily visualized preoperatively, is a rare but important cause of pain and can potentially be a source for early degeneration and progression to osteoarthritis. We present three cases, arthroscopic surgery of incarcerated acetabular osseo-labral fragment following reduction of traumatic hip fracture-dislocation.
Acetabulum* ; Arthroscopy* ; Head ; Hip Dislocation* ; Hip Joint ; Hip* ; Osteoarthritis ; Pathology

Calcifying aponeurotic fibroma is a rare soft tissue tumor that mostly occurs in the distal extremities of children and adolescents. We report here on a case of calcifying aponeurotic fibroma of the right elbow in an 8-year-old boy, and the tumor was diagnosed by surgical excision. The patient complained of painless swelling and mild limitation of the range of motion of the elbow joint. Radiologically, the mass was ill-defined and showed stippled calcification with shallow bony erosion. Microscopically, the tumor was composed of spindle cells with nodular deposits of hyalination and calcification, and these deposits were surrounded by palisading polygonal plump cells. Immunohistochemically, the tumor showed a diffuse positive expression for CD99 and negativity for smooth muscle actin, S-100 protein and CD34. The patient has been well with no signs of recurrence during the 42 months after surgery.
Actins ; Adolescent ; Child ; Elbow ; Elbow Joint ; Extremities ; Fibroma ; Humans ; Hyalin ; Muscle, Smooth ; Range of Motion, Articular ; Recurrence ; S100 Proteins ; Soft Tissue Neoplasms

We report one case of renal PV infection after renal allograft transplantation leading to graft dysfunction. According to prior reports, PV induced interstitial nephritis might be a cause of graft loss. Pathologic findings show varying degrees of interstitial infiltration and tubular degenerative changes, which resemble acute cellular rejection. Therapeutic strategies have not yet been developed. Case ; A 23 years old male underwent renal transplantation from his HLA haploidentical 25 year old sister. His renal function had been good with cyclosporin, steroid and azathioprine until 9 months after transplantation, when his serum creatinine level rose to 2.2mg/dl. The renal biopsy revealed diffuse lymphocyte infiltration in the interstitium and feature of the tubulitis. Also, giant tubular epithelial cells with large, hyperchromic nuclei were present. Despite steroid pulsing and OKT3, renal function progressively de- teriorated. After 10 days of OKT3 therapy, the patient suffered from high fever, dyspnea and general aches. A chest X-ray revealed interstitial infiltration in both lung fields and the cytomegalovirus PCR (polymerase chain reaction) test of serum and blood was positive. Intravenous ganciclorvir was administered and immunosuppressants were tapered. 4 months after admission, he lost his graft function and underwent hemodialysis. The aforementioned renal biopsy was retested immunohistochemically. Nuclear inclusions in renal tubular epithelial cells were shown and these inclusions were reacted positively with PV monoclonal antibodies.
Adult ; Allografts* ; Antibodies, Monoclonal ; Azathioprine ; Biopsy ; Creatinine ; Cyclosporine ; Cytomegalovirus ; Dyspnea ; Epithelial Cells ; Fever ; Humans ; Immunosuppressive Agents ; Intranuclear Inclusion Bodies ; Kidney Transplantation ; Lung ; Lymphocytes ; Male ; Muromonab-CD3 ; Nephritis, Interstitial ; Polymerase Chain Reaction ; Renal Dialysis ; Siblings ; Thorax ; Transplants ; Young Adult

Sirtuins (SIRTs) belong to the nicotinamide adenine dinucleotide (NAD+)-dependent class III histone deacetylase family. They are key regulators of cellular and physiological processes, such as cell survival, senescence, differentiation, DNA damage and stress response, cellular metabolism, and aging. SIRTs also influence carcinogenesis, making them potential targets for anticancer therapeutic strategies. In this study, we investigated the anticancer properties and underlying molecular mechanisms of a novel SIRT1 inhibitor, MHY2251, in human colorectal cancer (CRC) cells. MHY2251 reduced the viability of various human CRC cell lines, especially those with wild-type TP53. MHY2251 inhibited SIRT1 activity and SIRT1/2 protein expression, while promoting p53 acetylation, which is a target of SIRT1 in HCT116 cells. MHY2251 treatment triggered apoptosis in HCT116 cells. It increased the percentage of late apoptotic cells and the sub-G1 fraction (as detected by flow cytometric analysis) and induced DNA fragmentation. In addition, MHY2251 upregulated the expression of FasL and Fas, altered the ratio of Bax/Bcl-2, downregulated the levels of pro-caspase-8, -9, and -3 proteins, and induced subsequent poly(ADP-ribose) polymerase cleavage. The induction of apoptosis by MHY2251 was related to the activation of the caspase cascade, which was significantly attenuated by pre-treatment with ZVAD-FMK, a pan-caspase inhibitor. Furthermore, MHY2251 stimulated the phosphorylation of c-Jun N-terminal kinase (JNK), and MHY2251-triggered apoptosis was blocked by pre-treatment with SP600125, a JNK inhibitor. This finding indicated the specific involvement of JNK in MHY2251-induced apoptosis. MHY2251 shows considerable potential as a therapeutic agent for targeting human CRC via the inhibition of SIRT1 and activation of JNK/p53 pathway.

PURPOSE: Premature ejaculation is a common male sexual dysfunction and has an adverse effect on QoL(quality of life). Chronic pelvic pain syndrome(CPPS) is also a common and serious health problem affecting QoL. Although both disorders are common their etiopathogeneses are not well understood. We investigated the prevalence and effect of premature ejaculation on erectile function in CPPS patients and compared these patients with healthy control subjects. MATERIALS AND METHODS: 638 CPPS patients and 102 healthy controls were enrolled in this study. Each patient was given a questionnaire consisting of 3 parts: a demographic data questionnaire, the Korean version of the NIH-CPSI(National Institutes of Health-Chronic Prostatitis Symptom Index), and IIEF(International Index of Erectile Function). Premature ejaculation was defined as intravaginal ejaculation latency of less than 3 minutes with the same partner for at least 6 months. RESULTS: 303 patients with CPPS and 83 healthy controls were eligible for the analysis. The rate of premature ejaculation was much higher in patients with CPPS(71.62%) than healthy controls(22.89%), and this difference was statistically significant(p < 0.01). In the patients with CPPS, the frequency of sexual intercourse per month during the last 3 months was 4.79+/-3.43. In the patients with CPPS, the mean scores for IIEF-EF(erectile function), IIEF-IS(intercourse satisfaction), IIEF-OF(orgasmic function), IIEF-SD(sexual desire) and IIEF-OS(overall satisfaction) were 21.7+/-6.4, 8.5+/-2.9, 7.4+/-2.5, 5.3+/-2.0 and 5.2+/-2.1, respectively. Each mean IIEF domain score was lower than healthy controls, and these differences were statistically significant. But in the patients with CPPS categorized in IIIa and IIIb, the frequency of sexual intercourse and each IIEF domain score showed no difference. CONCLUSIONS: The rate of premature ejaculation was higher in the patients with CPPS than healthy controls.
Academies and Institutes ; Coitus ; Ejaculation ; Humans ; Male ; Pelvic Pain* ; Premature Ejaculation* ; Prevalence* ; Prostatitis