1.A Case of Leiomyoblastoma.
Ok Jae LEE ; Jee Hoon LEE ; Woo Song HA ; Kyung Hyuck KO
Korean Journal of Gastrointestinal Endoscopy 1996;16(6):989-993
Leiomyoblastoma is uncommon and has been known as a neoplasm of smooth muscle origin. However, with recent pragress in immunohistochemical staining techniques, many clinicopathological discrepancies have been pointed out about the origin of leiomyoblastoma. We present here a case of gastric leiomyoblastoma did not expressed desmin and neuron specific enolase, and was thought to be of unknown derivation.
Desmin
;
Leiomyoma, Epithelioid*
;
Muscle, Smooth
;
Phosphopyruvate Hydratase
2.A Case of Leiomyoblastoma.
Ok Jae LEE ; Jee Hoon LEE ; Woo Song HA ; Kyung Hyuck KO
Korean Journal of Gastrointestinal Endoscopy 1996;16(6):989-993
Leiomyoblastoma is uncommon and has been known as a neoplasm of smooth muscle origin. However, with recent pragress in immunohistochemical staining techniques, many clinicopathological discrepancies have been pointed out about the origin of leiomyoblastoma. We present here a case of gastric leiomyoblastoma did not expressed desmin and neuron specific enolase, and was thought to be of unknown derivation.
Desmin
;
Leiomyoma, Epithelioid*
;
Muscle, Smooth
;
Phosphopyruvate Hydratase
3.A Case of Myxoid Dermatofibrosarcoma Protuberans.
Yeon Ju HONG ; You Won CHOI ; Ki Bum MYUNG ; Hae Young CHOI
Annals of Dermatology 2011;23(3):379-381
Dermatofibrosarcoma protuberans (DFSP) is a slowly growing dermal spindle cell tumor and its myxoid variant, a rare type of DFSP, is characterized by extensive myxoid degeneration. We present the case of a 69-year-old woman with a multinodular reddish plaque on her trunk. Histopathologically, the tumor was located in the dermis and consisted of uniform spindle-shaped cells, showing strongly positive reaction for CD34, and negative for both S-100 and desmin. In addition to the typical storiform pattern, prominent myxoid stromal changes were demonstrated. Herein, we report an interesting case of myxoid DFSP, rarely reported in the dermatology literature.
Aged
;
Dermatofibrosarcoma
;
Dermatology
;
Dermis
;
Desmin
;
Female
;
Humans
4.Angiomatoid Fibrous Histiocytoma: A Case Report.
Kyungeun KIM ; Jong Seok LEE ; Kyung Ja CHO
Korean Journal of Pathology 2006;40(5):377-380
We report on a case of angiomatoid fibrous histiocytoma located deep in subcutaneous tissue of the left shoulder in an 11-year-old boy. An ovoid firm mass was slowly increasing in size for 5 months without any pain or tenderness. The tumor was grossly multicystic, with dense fibrous capsule and it measured 7.5 x 7.5 x 4.0 cm. The locules contained hemorrhagic fluid, and the inner surface was purplish brown and trabecular. The septal solid areas were cellular, and they consisted of histiocytoid spindle cells that were arranged in a storiform or fascicular pattern. The tumor cells showed immuno-positivity for CD99, CD68 and desmin. These findings were compatible with angiomatoid fibrous histiocytoma of an uncommon location.
Child
;
Desmin
;
Histiocytoma, Benign Fibrous*
;
Humans
;
Male
;
Shoulder
;
Subcutaneous Tissue
5.A Case of Primary Leiomyosarcoma of the Vagina.
Moo Cheol SHIN ; Sang Cheol KWEON ; Heung Gon KIM ; Hyang Jeong JO ; Ki Jung YUN ; Hyung Bae MOON
Korean Journal of Obstetrics and Gynecology 1997;40(1):215-217
The vagina is an infrequent site of primary sarcomas, which are less than 2% of all malignant vaginal neoplasm. The most common malignant mesenchymal tumor of the vagina is rhabdomyosarcoma, but leiomyosarcoma is rare type tumor of the vagina. Microscopically, spinle cells with pleomorphic nuclei and mitotic figures were frequently noted, but cross-striations were not found in the tissue. Alpha-smooth muscle actin and desmin were positive, but sarcomeric actin was negative in the tumor cells. The authors report a case of primary leiomyosarcoma of the vagina with brief literature review.
Actins
;
Desmin
;
Leiomyosarcoma*
;
Rhabdomyosarcoma
;
Sarcoma
;
Vagina*
;
Vaginal Neoplasms
6.A Case of Fibrous Hamartoma of Infancy.
Sung Jun KIM ; Sang Jai JANG ; Myeon Soo KIM ; Seung Lee SEO ; Yong Suk LEE
Korean Journal of Dermatology 2001;39(10):1186-1189
Fibrous hamartoma of infancy (FHI) is an uncommon benign fibrous proliferation, usually presenting as a single nodule. A 17-month-old male patient had an asymptomatic fingertip-sized subcutaneous nodule on the right side of the back for 6 month. Histopathologic findings showed the typical feature of FHI, that is well defined intersecting fibrous trabeculae, small immature cells within loosely textured areas, and mature adipose areas in the lower dermis and subcutaneous layer. Immunohistochemically, vimentin positivity was present in both the trabecular and loosely textured areas, but desmin was not present in any components which is positive usually only in trabecular areas. The lesion was excised without recurrence. We experienced and report an uncommon case of fibrous hamartoma of infancy in a 17-month-old male patient.
Dermis
;
Desmin
;
Hamartoma*
;
Humans
;
Infant
;
Male
;
Recurrence
;
Vimentin
7.The Diagnostic Utility of Mesothelial Markers in Distinguishing between Reactive Mesothelial Cell and Adenocarcinoma Cells in Serous Effusions with Cytospin Preparation.
Korean Journal of Cytopathology 2006;17(2):108-115
Evaluation of serous effusions can include immunocytochemical stains that differentiate reactive mesothelial cell from adenocarcinoma cell. Among several positive mesothelial cell markers, we used desmin, CK5/6, WT1 and calretinin all known to have high sensitivity and specificity as selective mesothelial cell markers. We studied smears obtained with cytospin from 15 malignant and eight benign effusions. The mesothelial cells were positively stained by desmin, CK5/6, WT1 and calretinin in 60.9%, 29.1%, 26.7% and 56.5%, respectively among 8 benign and 15 malignant effusions; the adenocarcinoma cells were positively stained 6.7%, 13.3%, 1.0% and 0.0%, respectively among 15 malignant effusions. The percentage of positively stained mesothelial cells were somewhat lower for all antibodies compared to the results of previous studies. This was likely due to the differences in preparation methods and fixatives among studies. In conclusion, the use of desmin and calretinin were more valuable than CK5/6 and WT1 for distinguishing between reactive mesothelial cell and adenocarcinoma cells in serous effusion; however, choice of the proper preparation methods and fixatives are also important
Adenocarcinoma*
;
Antibodies
;
Calbindin 2
;
Coloring Agents
;
Desmin
;
Fixatives
;
Sensitivity and Specificity
8.A Case of Granular Cell Tumor.
Ji Ho RYOU ; Jae Young CHOI ; Mu Hyoung LEE
Korean Journal of Dermatology 1996;34(5):861-864
Granular cell tumors were originally described in 1926 by Abrikossoff as myoblastic myomas. They usually occur as solitary tumors but can be multiple in about 10% of cases. They have a predilection for the head, neck and tongue, but also occur in many other organs. Authors experienced a 37 year-old male patient with a granular cell tumor which exhibited the distinctive histopathologic appearance on light microscopy and electromicroscopy Also, granular cells were S-100 protein, vimentin and CD68 immunoreactive, but desmin and GFAP showed negative immunostaining. This finding suggests a neural origin for grenular cell tumors.
Adult
;
Desmin
;
Granular Cell Tumor*
;
Head
;
Humans
;
Male
;
Microscopy
;
Myoblasts
;
Myoma
;
Neck
;
S100 Proteins
;
Tongue
;
Vimentin
9.Primary Myxoid Leiomyoma of the Liver.
Hee Seung CHOI ; Chang Won JUNG ; Soo Youn CHO ; Sang Bum KIM ; Sunhoo PARK
Korean Journal of Pathology 2014;48(1):54-57
Herein, we report a case of primary myxoid leiomyoma of the liver. A 60-year-old woman complained of upper abdominal fullness. Computed tomography showed a solid tumor (8 cm) in the liver. The patient underwent right hepatectomy and histological findings from the resected specimen revealed scattered bland spindle cells in a background of exuberant myxoid material. The tumor cells were immunoreactive for smooth muscle actin and desmin. No other lesions were found elsewhere in the body. Thus, the tumor was diagnosed as a primary myxoid leiomyoma of the liver.
Actins
;
Desmin
;
Female
;
Hepatectomy
;
Humans
;
Immunohistochemistry
;
Leiomyoma*
;
Liver*
;
Middle Aged
;
Muscle, Smooth
;
Myxoma
10.Clinical Effectiveness of Diagnosis Using Immunohistochemistry and New Grade in Gastrointestinal Stromal Tumors (GISTs).
Chae Young LEE ; Jin Cho KIM ; Won Woo KIM ; Hyung Min CHIN ; Wook KIM ; Cho Hyun PARK ; Hae Myung JEON ; Seung Man PARK ; Keun Woo LIM ; Woo Bae PARK ; Seung Nam KIM ; Gyo Young LEE ; Gyeong Sin PARK ; Do Young SONG ; Jong Ho JOO
Journal of the Korean Surgical Society 2003;64(6):471-479
PURPOSE: Paraffin-embedded tissue samples from the gastrointestinal tract, which had been diagnosed as tumors of a mesenchymal origin, were reviewed by an immunohistochemical staining method. The prognostic significances of the immunohistochemical subtypes and anatomical locations were also investigated. GIST, as a new grading system, was compared with the pre-existing system for its useful prognostic significance. METHODS: 122 cases were evaluated and classified by immunohistochemical staining for KIT, CD34, actin, desmin, vimentin, S-100 protein and NSE. RESULTS: Positivity for both KIT and CD34 of 92.6 and 73.8%, respectively, indicated that KIT was more effective for the diagnosis of GISTs. The stomach (62.3%) and small bowel (23.7%) were most common organs of GIST. There was no difference in the prognosis between these two organs. Immunophenotypically, the uncommitted, myoid, combined and neural types were 37.7, 23.7, 20.2 and 7%, respectively. There was no significant difference in the prognosis between these types. The old grading system showed no difference between the borderline and malignant groups (P=0.14), whereas, the new grading system showed a significant difference between the intermediate and high risk groups (P=0.01). CONCLUSION: KIT is more useful for the diagnosis of GOSTs. The immunophenotypical classification and anatomical location showed no prognostic significance in GISTs. Therefore, the new grading system might be more useful than older system.
Actins
;
Classification
;
Desmin
;
Diagnosis*
;
Gastrointestinal Stromal Tumors*
;
Gastrointestinal Tract
;
Immunohistochemistry*
;
Prognosis
;
S100 Proteins
;
Stomach
;
Vimentin