No absract available.
Desensitization, Immunologic*

No abstract available.
Desensitization, Immunologic

Contraindications ; Desensitization, Immunologic ; Humans

Desensitization, Immunologic ; trends ; Humans

Allergen specific immunotherapy is a medical treatment aiming at patients suffering from allergies that are insufficiently controlled by symptomatic treatments. Allergen immunotherapy rehabilitates the immune system. Subcutaneous immunotherapy (SCIT) is the historical route of administration and consists of allergen extract injections. SCIT has proven efficacy in allergic rhinitis and asthma, but it requires regular injections at the hospital and carries the risk of potentially serious systemic allergic reactions in response to the treatment itself. Sublingual immunotherapy (SLIT) offers several specific advantages over SCIT. SLIT is more easily administered, avoids cumbersome injections regimens, and carries a much lower risk of anaphylactic shock compared with SCIT. So, this article will discuss the mechanisms of action, advantages, and limitations of SLIT for allergic rhinitis.
Anaphylaxis ; Asthma ; Desensitization, Immunologic ; Humans ; Hypersensitivity ; Immune System ; Immunotherapy ; Rhinitis* ; Sublingual Immunotherapy*

Even though atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases, its treatment remains a challenge in clinical practice, with most approaches limited to symptomatic, unspecific anti-inflammatory, or immunosuppressive treatments. Many studies have shown AD to have multiple causes that activate complex immunological and inflammatory pathways. However, aeroallergens, and especially the house dust mite (HDM), play a relevant role in the elicitation or exacerbation of eczematous lesions in many AD patients. Accordingly, allergen-specific immunotherapy has been used in AD patients with the aim of redirecting inappropriate immune responses. Here, we report three cases of refractory AD sensitized to HDM who were treated with sublingual immunotherapy.
Dermatitis, Atopic* ; Desensitization, Immunologic* ; Humans ; Immunotherapy ; Pyroglyphidae* ; Skin Diseases ; Sublingual Immunotherapy

OBJECTIVETo compare the difference in the effects of subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT) on immunological responses in children with asthma.

METHODSA total of 86 children with asthma caused by dust mites were enrolled and divided into a SLIT group (n=29), a SCIT group (n=13), a group receiving complete SCIT course (complete SCIT group; n=14), and a group receiving conventional medication (control group, n=30). Peripheral blood mononuclear cells were isolated and stimulated with house dust mite extract for 48 hours in vitro, and the percentage of regulatory T cells (Treg%) in CD4+ T cells was measured by flow cytometry. Analysis of variance with repeated measures was applied to compare the changes in humoral immunological indices and therapeutic effects in the SCIT and SLIT groups before treatment and after 6 and 12 months of treatment.

RESULTSBefore antigenic stimulation, Treg% in CD4(+) T cells in the SCIT group was significantly higher than that in the SLIT and control groups; after antigenic stimulation was given, Treg% in the four groups decreased significantly. After 6 and 12 months of immunotherapy, the SCIT group had significant changes in serum sIgE and sIgG4 levels, while the SLIT group only showed a significant change in serum sIgE level.

CONCLUSIONSTemporal difference exists in different immunotherapies to cause immunological responses in children with asthma, and immunological responses induced by SCIT may occur earlier.

Adolescent ; Asthma ; immunology ; therapy ; Child ; Child, Preschool ; Desensitization, Immunologic ; Female ; Humans ; Male ; Sublingual Immunotherapy

Dendritic cells (DCs) is known as the most potential and professional antigen presenting cells (APC), it mainly involves in the cellular immunity and T cell dependent humoral immunity, which plays a key role in the immune response and is one of the most hot areas in immunology in recent years. DCs plays a key role in allergic rhinitis (AR) and is one of the most important mechanism of AR treating by sublingual immunotherapy (SLIT). This article reviewed the mechanism of the role of DCs in AR and AR treating by SLIT.
Animals ; Dendritic Cells ; immunology ; Desensitization, Immunologic ; Humans ; Rhinitis, Allergic ; therapy ; Sublingual Immunotherapy

Allergens ; immunology ; Desensitization, Immunologic ; Humans

Current treatment options for allergic rhinitis (AR) include allergen avoidance and environmental control, pharmacotherapy, nasal surgery and immunotherapy. Among these, immunotherapy is the only therapeutic option that modifies fundamental immunologic mechanism by inducing desensitization. Specific allergen immunotherapy has been used for 1 century since 1911 and subcutaneous immunotherapy (SCIT) has been demonstrated to be effective in asthma and AR. However, SCIT has several disadvantages such as inconvenience, invasiveness and potentially severe systemic reactions. Thus, sublingual immunotherapy (SLIT) has recently received much attention around the world as a treatment for AR and is now widely used to replace the subcutaneous route. SLIT has recently been introduced in Korea and is now available for AR treatment in the Asia-Pacific region. This review offers better understanding of SLIT for AR by summarizing published articles and our previous works regarding proposed mechanisms, indication and efficacy, safety and adverse events, and compliance.
Administration, Sublingual ; Asthma ; Compliance ; Desensitization, Immunologic ; Drug Therapy ; Immunotherapy ; Korea ; Nasal Surgical Procedures ; Rhinitis ; Rhinitis, Allergic ; Sublingual Immunotherapy