Objective To study the clinical curative effect and mechanism of Senggin Xinmaitong capsule in the treatment of non -proliferative diabetic retinopathy.Methods One hundred and twenty patients with non -prolif-erative diabetic retinopathy were randomly divided into the observation group and control group.The control group was given the standard treatment according to the clinical diagnosis and treatment guidelines for diabetic retinopathy in China in 2014.The observation group was treated with Senggin Xinmaitong capsule on the basis of treatment of the control group.Treatment time was 6 months.Before treatment and after treatment,ELISA method was used to detect serum transforming growth factor beta 1 (TGF - 1 ),interleukin -6 (IL -6)and vascular endothelial cell growth factor (VEGF)levels,and according to the performance of the vision and fundus,the clinical efficacy was observed and compared between the two groups.Results Comparison between before treatment and after treatment,the serum levels of TGF -1,IL -6 and VEGF were[(65.19 ±4.53)μg/L vs.(32.90 ±5.17)μg/L,t =3.905],[(45.18 ± 3.28)pg/mL vs.(24.87 ±7.09)pg/mL,t =3.275],[(175.43 ±21.59)μg/L vs.(109.98 ±10.21 )μg/L,t =3.316]respectively in the observation group,while the levels of TGF - 1,IL -6 and VEGF were [(64.97 ± 5.37)μg/L vs.(50.91 ±4.85)μg/L,t =2.761],[(47.09 ±3.16)pg/mL vs.(35.28 ±5.10)pg/mL,t =2.874], [(168.17 ±28.05)μg/L vs.(147.09 ±12.38)μg/L,t =2.548]respectively in the control group,after treatment, the serum levels of TGF -1,IL -6 and VEGF were decreased in the two groups compared with pre treatment(all P <0.05),and the improvement in the observation group was significantly better than the control group[t value(IL -6, TGF -β1,VEGF)=3.031,3.003,3.006,all P <0.05].The clinical efficacy of the observation group was better than the control group,the difference was statistically significant (90.00% vs.73.33%,χ2 =2.872,P <0.05 ). Conclusion The Senggin Xinmaitong capsule can significantly improve the clinical symptoms of patients with non -proliferative diabetic retinopathy,increase the visual acuity level and down -regulation of inflammatory reaction,inhi-bition the level of VEGF,thus to delay the progression of the disease.

Objective To compare the effects of two kinds of small incision operation in patients with diabetic cataract.Methods 100 patients with diabetic cataract were randomly divided into the two groups:the observation group(n=50,76 eyes) and the control group(n=50 cases,73 eyes).The observation group was operated through small incision non-phacoemulsification.The control group was treated with small incision phacoemulsification.The two groups of visual acuity,corneal endothelial cell density,corneal edema and postoperative astigmatism were compared. Results Two different eye surgery before the vision was no significant difference in the distribution segment(χ2 =0.297,P>0.05).Different postoperative visual acuity eye segment distribution after 3d were significantly different (χ2 =1.163,P>0.05).Different postoperative visual acuity eye segment distribution after 1m were significantly different(χ2 =0.928,P >0.05).The control group preoperative corneal endothelial cell density was (2 369 ± 261)cells/mm2,the observation group (2 403 ±277)cells/mm2.Preoperative corneal endothelial cell density was no significant difference between the two groups(t=0.467,P>0.05).Postoperative 3d and 1m,corneal endothelial cell density was (1 635 ±189)cells/mm2 and (1 706 ±196) cells/mm2 in the control group,(1 931 ±207) cells/mm2 and (1 982 ±203)a/mm2 in the observation group.The observation of corneal endothelial cell density was significantly higher(t=2.726,2.460,all P<0.05).The incidence of postoperative corneal edema were 35.6%,51.3%,and the observation group was significantly higher(χ2 =4.960,P<0.05).The incidence of postoperative astigmatism were 42.5%,26.3%,and the observation group was significantly lower than those of the control group(χ2 =5.210,P<0.05).Conclusion Two small incision surgery has advantages and disadvantages,and the effect is quite.