1.Dermatitis Herpetiformis Resembing to Atopic Dermatitis: Report of a Case.
Chung Koo CHO ; Chong Uk LEE ; Tae Ha WOO
Korean Journal of Dermatology 1969;7(1):73-74
A case of dermatitis herpetiformis resembling atopic dermatitis is reported. The patient is 45 year-o1d male, who 6 months ago developed the pruritic erythematous vesicular eruptions on the left side of back and it gradually spread to the margin. He was treated with steroid but the lession had undergone exacerbation and remissions. Biopsy was performed on the vesicular lesion and revealed non-acantholytic subepidermal bulla with mild inflammatory cells infiltration and then he was treated with DDS for 2 months with good response.
Biopsy
;
Dermatitis Herpetiformis*
;
Dermatitis*
;
Dermatitis, Atopic*
;
Humans
;
Male
2.Dermatitis herpetiformis-like Linear IgA bullous disease in a Filipino
Lauren Camille B. Livelo ; Elisabeth Ryan ; Johannes Dayrit ; Ricky H. Hipolito
Journal of the Philippine Dermatological Society 2020;29(1):100-103
INTRODUCTION: Linear IgA bullous disease (LABD) is a rare autoimmune blistering disease characterized by subepithelial bullae and linear IgA deposition along the basement membrane zone of the epidermis. Lesions present as pruritic papulovesicles and tense bullae which may coalesce forming annular or polycyclic urticarial plaques with blistering on the edge of the lesions forming the classic “string of pearls” sign. Lesions may affect the face, trunk, and extensor extremities. Incidence rates range from 0.5 to 2.3 cases per million individuals per year. Due to its rare occurrence, there are only a fewdocumented reports on cases of LABD, particularly in the Filipino population.
CASE REPORT: A 33 year-old Filipino female consulted because of a 3-week history of severely pruritic vesicles and crusts on the face, trunk, and arms. Patient noted no gastrointestinal symptoms on consultation. Skin punch biopsy revealed subepidermal blisters with collection of neutrophils at the
dermal papillae. Direct immunofluorescence showed strong (+2) deposits of linear IgA at the dermo- epidermal junction in perilesional skin thus validating the diagnosis. The patient’s serum was negative for IgA anti-tissue transglutaminase and IgA antiendomysial antibodies. Patient was treated with topical corticosteroids and Dapsone 50 mgs OD with remarkable improvement.
CONCLUSION: Linear IgA bullous disease has very few reported cases especially in the Philippine setting. Dapsone is considered the first-line treatment. The disease may persist for a decade or longer, and relapses may occur. Careful history-taking accompanied by the histological, immunofluorescence, and serological findings must be done to ensure proper treatment and good prognosis.
Dermatitis Herpetiformis
;
Linear IgA Bullous Dermatosis
;
Immunoglobulin A
3.Juvenile DErmatitis Herpetiformis : Bullous Type: Report of a Case.
Korean Journal of Dermatology 1974;12(3):171-173
Dermatitis Herpetiformis rarely in childhood, and certain features of the disease in children differ from its manifestations in adults. Juvenile dermatitis herpetiformis appears not to be the same disease as the typical dermatitis herpetiformis of adults. Juvenile dermatitis herpetiformis has been described as a predomimantly bullous disease, but rarely papulovesicular eruptions. This bullous eruption in children must be considered in the several entities such as bullous pemphigoid and erythema multiforme. Juvenile bullous dermatitis herpetiformis has not responded routinely to sulfapyridine and sulfone therapy. A 15-month-old child whose skin lesions fulfilled clinical, histologic, and therapeutic criteria for Juvenile dermatitis hepetiformis is reported. The skin lesions showed bullous eruptions and also complained of severe itching sensation different from bullous Juvenile dermatitis herpetiformis.
Adult
;
Child
;
Dermatitis Herpetiformis*
;
Dermatitis*
;
Erythema Multiforme
;
Humans
;
Infant
;
Pemphigoid, Bullous
;
Pruritus
;
Sensation
;
Skin
;
Sulfapyridine
4.A Clinical Study on Dermatitis Herpetiformis.
Korean Journal of Dermatology 1978;16(5):383-389
A clinicopathological study was performed with 20 cases of dermatitis herpetifom is encountered at Department of Dermatology, College of Medicine, Busan National University Hospital during the period from January 1969 to August 1977. We used as criteria for diagnosis the history of chronicity and recurrence with good general health, pruritus, symmetric grouping of vesicles and papules, excoriat ions, pigmentations and ready response to DDS. The results were as folIows; 1.The age of onset was varied from 5 to 74 with most; prominent in the age group between 20 and 29 years. 2. Clinical forms included 16 cases of papulovesicular form, 1 case of papular form and, 3 cases of vesicobullous form. 3. The common predilection sites were scapular area, back, sacral area and extensor surfaces of extrernities while oral mucosa was affected in only one case. 4. Histopathological findings of 16 biopsy specimen obtained from the early vesicular lesions and surrounding erythematous areas showed subepidermal bullae in 12 cases and microabscess in 3 cases. 5. Most of the patients (80%) complained either moderate or severe pruritus.
Age of Onset
;
Biopsy
;
Busan
;
Dermatitis Herpetiformis*
;
Dermatitis*
;
Dermatology
;
Diagnosis
;
Humans
;
Ions
;
Mouth Mucosa
;
Pigmentation
;
Pruritus
;
Recurrence
5.A Case of Fulminant Linear IgA Bullous Dermatosis in an adult.
Soo Lieon PARK ; Chull Wan IHM
Korean Journal of Dermatology 1995;33(4):748-754
The linear IgA bullous dermatosis is a rare chronic vesicobullous disease resembling dermatitis herpetiformis or bullous pemphigoid. We report a case of linear IgA bullous dermatosis developed in a 16 year old female, whose cutaneous lesions were unusually acute. The urticarial wheals started on her buttock and spread to her entire body in two hours and generalized blistering de veloped within four days, The response by dapsone was also dramatic. Routine histological and both direct and indirect immunofluorescent microscopic findings were typical of linear IgA bullous dermatosis.
Adolescent
;
Adult*
;
Blister
;
Buttocks
;
Dapsone
;
Dermatitis Herpetiformis
;
Female
;
Humans
;
Linear IgA Bullous Dermatosis*
;
Pemphigoid, Bullous
6.Two Cases of Anti-p200 Pemphigoid.
Mi Ri KIM ; Jae Yong CHANG ; Soo Chan KIM
Korean Journal of Dermatology 2008;46(6):821-825
Anti-p200 pemphigoid is a recently defined subepidermal immunobullous disease. Most anti-p200 pemphigoid patients show the clinical features of bullous pemphigoid, dermatitis herpetiformis and linear IgA disease. It is characterized by the binding of circulating IgG autoantibodies to the dermal side of 1 M NaCl split skin, and by reactivity of these autoantibodies to a unique 200-kD antigen on immunoblot of dermal extract. On immunoelectron microscopic examination, these autoantibodies deposit at the lamina lucida-lamina densa interface. Herein, we report two cases of anti-p200 pemphigoid, as well as their favorable response to treatment with systemic corticosteroid, colchicine and dapsone.
Autoantibodies
;
Colchicine
;
Dapsone
;
Dermatitis Herpetiformis
;
Humans
;
Immunoglobulin A
;
Immunoglobulin G
;
Pemphigoid, Bullous
;
Skin
8.Six Cases of Dermatitis Herpetiformis.
Jung Uk YI ; Chang Woo LEE ; Jae Hong KIM
Korean Journal of Dermatology 1989;27(5):577-581
Dermatitis herpetiformis is a chronic, intensely itchy, papulovesicular skin disorder of unknown cause, which is usually symmetrically distributed on extensor surface. Most patients have an associated gluten-sensitive enteropathy which is usually asymptornatic. We report six cases of dermatitis herpetiformis diagnosed by direct immunofluorescence studies. The patients have had characteristic features of dennatitis herpetiformis, such as vesicles, erythernatous papules, urticaria-like plaques, and hypopigmentation or hyperpigmentation, dispersed on the neck, back, and arms. None of the patients had subjective symptoms associated with gluten-sensitive enteropathy. Clinicians should be aware of the clinical features of this disease to avoid possible misdiagnosis, and to provide better therspeutic approaches in time.
Arm
;
Celiac Disease
;
Dermatitis Herpetiformis*
;
Dermatitis*
;
Diagnostic Errors
;
Fluorescent Antibody Technique, Direct
;
Humans
;
Hyperpigmentation
;
Hypopigmentation
;
Neck
;
Skin
9.A Case of Dermatitis Herpetiformis Associated with Erythema Annulare Centrifugum.
Tae An CHUNG ; Ho Suk SEONG ; Soon Taek KIM
Korean Journal of Dermatology 1973;11(2):89-91
A case of dermatitis herpetiformis assaciated with erythema annulare centrifugum is reported. The patient was a 21 year-old male, who had papulovesieles, erythematous lesions, pigmentation, and erythema annulare centrifugum lesions on the trunk, shoulders, buttocks and extensor surfaces of the extremities, and severe itching sensation of 9 months' duration. The skin biopsy from the vesicular and erythema annulare centrifugum lesion showed subepidermal bulla and vesicles with neutrophil and eosinophil infiltrations.
Biopsy
;
Buttocks
;
Dermatitis Herpetiformis*
;
Dermatitis*
;
Eosinophils
;
Erythema*
;
Extremities
;
Humans
;
Male
;
Neutrophils
;
Pigmentation
;
Pruritus
;
Sensation
;
Shoulder
;
Skin
;
Young Adult
10.Dermatitis Herpetiformis Associated with Bronchogenic Carcinoma: Report of a Case.
Duck Hyun KIM ; Hong Il KOOK ; Tae Ha WOO
Korean Journal of Dermatology 1973;11(1):53-56
A case of dermatitis herpetiformis associated with bronchogenic carcinoma is reported. The 56 year-old female patient developed cough with expectorants and exertional dyspnea one year ago, and also showed the pinhead to rice sized erythematous papulovesicular eruptions on the back and extremities with severe itching sensation one month ago. Bronchogenic carcinoma was confirmed by chest X-ray and so on. Skin biopsy was performed on the vesicular lesion and reveled subepidermal bullae with eosinophilic and neutrophilic inflammatory cells infiltertaion.
Biopsy
;
Carcinoma, Bronchogenic*
;
Cough
;
Dermatitis Herpetiformis*
;
Dermatitis*
;
Dyspnea
;
Eosinophils
;
Expectorants
;
Extremities
;
Female
;
Humans
;
Middle Aged
;
Neutrophils
;
Pruritus
;
Sensation
;
Skin
;
Thorax