No absteact available.
Dermatitis, Atopic* ; Diagnosis*

This prospective study was designed to evaluate the major and minor features of Hanifin and Rajka in 100 adult patients with atopic dermatitis. The results showed that 65% of the patients had 4 major features and 80% had 6 minor features. The specific features included itchy (100%), chronic progress (100%), history of atopic conditions (79%), lichenification in flexural areas (78%), non-specific hand dermatitis (75%), onset before 5 years of age (74%), xerosis (63%). Non-specific features included the progress has been influenced by environmental and emotional factors (100%), white dermographism (79%). Uncommon features included Denie-Morgan folds (5%) and anterior neck folds (5%). Based on these results, a minimum clinical diagnostic criteria was proposed, by which to be diagnosed with atopic dermatitis, a patient must have itching plus 4 or more followed features: history of atopic conditions, lichenification in flexural areas or eczema on face in children under 10 years of age, chronic progress, non-specific hand dermatitis, onset before 5 years of age and xerosis.
Dermatitis, Atopic ; diagnosis ; adult

For allergists, itch is the most important symptom of atopic dermatitis (AD), and at the same time, the most difficult-to-manage complaint of atopic patient. Rather than just one symptom of AD, itch has more profound clinical significance in the following sense: itch, as a key component of so-called 'itch-scratch' vicious-cycle, plays a central role in the development and persistence of AD, thus, treating itch is not just alleviating one symptom of AD, but stopping genesis and progress of AD. In other words, itch is AD in itself. Pathomechanism underlying development of itch in AD could be summarized as follows: First, exogenous triggering factors penetrate impaired barrier, leading to allergic skin inflammation. Resulting characteristic itch of AD is amplified through the 'itch --> scratch --> inflammation --> (again) --> itch -->...' vicious-cycle. Thus, pathomechanism-based management strategy could be provided accordingly-avoidance of triggering factor, repair of impaired barrier, control of skin inflammation, and decreasing desire for itch/scratch. Among them, controlling inflammation is thought to be most effective measure based on the clinical experiences, for skin inflammation, as one of key components in 'itch-scratch-inflammation' vicious-cycle, at the same time, is a crucial connecting link between OUTSIDE and INSIDE. However, individualized approach should be taken for patient per se. Finally, following topics may be future topics for doctors always hungry for new weapon against AD and patients suffering from this out-of-place (a-top-y) disease: central itch pathway-emerging new hero; neural sensitization - still in the Dark-Ages in terms of diagnosis and management; and scratch-just in its infancy.
Dermatitis, Atopic* ; Diagnosis ; Humans ; Inflammation ; Skin

BACKGROUND: Recently doubts have been raised regarding the diagnostic significance of some of the minor clinical features of atopic dermatitis (AD) proposed by Hanifin and Rajka. Some of them may be nonspecific and racial difference was suggested. OBJECTIVE: The purpose of this study is to evaluate the diagnostic significance of 14 minor clinical features out of Hanifin and Rajka's 23 minor features of AD in the Korean pediatric population. The significance of 5 more items was evaluated as additional minor features. METHODS: The difference in frequency of the total 19 features of AD was compared between 100 patients with AD and 76 controls. RESULTS: Fourteen of these were shown to be significantly more frequent in patients than in controls including our 5 additional clues such as scalp scaling, postauricular fissure, infraauricular fissure, forehead lichenification, and infragluteal eczema. CONCLUSION: Our study about the minor features may be a valuable guideline for the diagnosis of AD in the Korean pediatric population.
Dermatitis, Atopic* ; Diagnosis ; Eczema ; Forehead ; Humans ; Scalp

BACKGROUND: Recently doubts have been raised regarding the diagnostic significance of some of the minor clinical features of atopic dermatitis (AD) proposed by Hanifin and Rajka. Some of them may be nonspecific and racial difference was suggested. OBJECTIVE: The purpose of this study is to evaluate the diagnostic significance of 14 minor clinical features out of Hanifin and Rajka's 23 minor features of AD in the Korean pediatric population. The significance of 5 more items was evaluated as additional minor features. METHODS: The difference in frequency of the total 19 features of AD was compared between 100 patients with AD and 76 controls. RESULTS: Fourteen of these were shown to be significantly more frequent in patients than in controls including our 5 additional clues such as scalp scaling, postauricular fissure, infraauricular fissure, forehead lichenification, and infragluteal eczema. CONCLUSION: Our study about the minor features may be a valuable guideline for the diagnosis of AD in the Korean pediatric population.
Dermatitis, Atopic* ; Diagnosis ; Eczema ; Forehead ; Humans ; Scalp

Lidex(Fluacinonide) 0.05% in FAPG base is a new fluorinated topical corticosteroid. 30 patients with different steroid responsive dermatoaes were treated with 0. 05% Lidex. The diagnosis included atopic dermatitis, contact dermatitis, neurodermatitis, seborheic dermatitis, nummular eczema, psoriasis vulgaris, chronic eczema and pustulosis pahmaris et plantaris. In the majority of cases Lidex cream produced excellent to good result(70%) after unoccluded application 3 times daily for 10 days. Two patients complained burning or itching sensation after the initial application of Lidex. 0.05% Lidex was compared with 0. 25% Desoxymethasone cream and 0. 25% Fluocortolone cream and was found slightly more effective in Lidex.
Burns ; Dermatitis ; Dermatitis, Atopic ; Dermatitis, Contact ; Desoximetasone ; Diagnosis ; Eczema ; Fluocinonide* ; Fluocortolone ; Humans ; Neurodermatitis ; Pruritus ; Psoriasis ; Sensation

Atopic dermatitis is estimated to affect 15-20% of the childhood population and there id considerable evidence that the prevalence is increasing. But it is frequently under diagnosed and inappropriately treated yet. Atopic dermatitis can have a large social;. emotional and financial effect on the child and their family. Atopic dermatitis also commonly predated the development of asthma and allergic rhinitis. Therefore early diagnosis and proper treatment are the key for control the atopic dermatitis itself and modify the future repiratory allergies. This review will cover the new diagnostic criteria and treatment briefly.
Asthma ; Child ; Dermatitis, Atopic* ; Early Diagnosis ; Humans ; Hypersensitivity ; Prevalence ; Rhinitis

Atopic dermatitis (AD) is a common allergic inflammatory skin disorder characterized by chronically relapsing, often intensely pruritic eczematous lesions. AD occurs primarily in children, with a prevalence of 10% to 20% of children worldwide. The pathogenesis of AD is complex and multifactorial. Genetic factors, environmental factors, immune dysfunction, and skin barrier dysfunction play a role in its development. Because there is no definitive laboratory test, AD is diagnosed based on a combination of clinical symptoms. Regardless of the severity of the disease, skin-directed therapies, including skin care, trigger avoidance, and acute treatment for flares, should be implemented for every patient. Educating patients and family members regarding the pathogenesis of the disease, treatment goals, and prognosis plays an extremely important role in the management of AD. Personalized, optimized, and well-communicated treatment plans should be continually refined during regular follow-ups.
Child* ; Dermatitis ; Dermatitis, Atopic* ; Diagnosis* ; Follow-Up Studies ; Humans ; Immunologic Factors ; Prevalence ; Prognosis ; Skin ; Skin Care

BACKGROUND: Allergic skin diseases such as atopic dermatitis and urticaria are known to be mediated by IgE. It is important to confirm a causative allergen for diagnosis and treatment. The multiple allergosorbent test (MAST) is a simple method for simultaneously measuring total and allergen-specific IgE. OBJECTIVE: The purpose of this study was to analyze results from the MAST, which measures total and specific IgE, and to compare the different results. METHODS: We reviewed the MAST results of 270 allergic disease patients tested between June 2007 and May 2012. RESULTS: There were statistical differences in total IgE production and in positive sensitization to specific allergens between the disease groups. The level of total IgE and positive rates of specific IgE were highest in atopic dermatitis patients, followed by urticaria, allergic contact dermatitis, and pruritus patients. Atopic dermatitis patients had significantly more allergens than those with other diseases. There were no statistical differences in total IgE level, rates of positive sensitization to specific allergens, and the number of causative allergens between the patients with acute and chronic urticaria. CONCLUSION: Each disease showed a different IgE pattern. Atopic dermatitis showed the highest level of serum IgE. There were no differences in IgE levels between acute and chronic urticaria patients. We identified an increase in IgE level in allergic contact dermatitis patients. Further study is needed to determine whether these patterns could be useful in diagnosis and choice of treatment methods.
Allergens ; Dermatitis, Allergic Contact ; Dermatitis, Atopic ; Diagnosis ; Humans ; Immunoglobulin E ; Immunoglobulins ; Pruritus ; Skin Diseases* ; Urticaria

Dermatitis, Atopic ; diagnosis ; drug therapy ; Diagnosis, Differential ; Drugs, Chinese Herbal ; therapeutic use ; Humans ; Medicine, Chinese Traditional