Objective To investigate the effects of the treatment of open injury and orthopedic postoperative wound infections with Vacuum Sealing Drainage.Methods Retrospective analysis of the clinical results of 32 patients with open injury or orthopedic postoperative wound infections in our hospital.Results Follow the indications and contraindications strictly and ensure right pressure,all the infection of wounds was controlled,and split skin graft survived.Without the package and pressurized fixation,the wounds healed better.Conclusion Vacuum Sealing Drainage can be considered one of the effective methods to treat the open injury or orthopedic postoperative wound infections and is worthy to be carried out as a routine.For patients with vascular rupture or defect,when there was still skin defects after vascular graft repair,as long as covered vascular anastomosis with the surrounding skin and soft tissue during the operation,there was still can use closed vacuum sealing drainage to cover the wound to prevent infection.

Objective:To prepare clindamycin loaded chitosan sustalned‐release microspheres ,determine drug loading and drug encapsulation efficiency of the microspheres ,and observe the effect of sustalned‐release and bacteriostasis in vitro .Methods:The microspheres were prepared by emulsified chemical cross‐linking method . The morphology and particle size of microspheres were observed by transmission electron microscopy and laser diffraction particle size analyzer .The drug loading and drug encapsulation efficiency of clindamycin loaded chitosan sustalned‐release microspheres were tested by UV spectrophotometry method .The effect of drug sustalned‐release and bacteriostasis in vitro was studied by establishing release system in vitro .The bacteriostasis of microspheres in vitro was observed by plotting the area‐time curve of inhibition ring . Results:The size of clindamycin loaded chitosan sustalned‐release microspheres was uniform ,while the dispersion was good . The average particle size of the microspheres was (153 .2 ± 13 .7)μm .The average drug loading was(39 .8 ± 1 .6)% .The mean encapsulation efficiency was (79 .6 ± 3 .5)% .The cumulative release percentage of clindamycin loaded chitosan sustalned‐release microspheres in pH 7 .4 phosphate buffer saline(PBS) was 16 .5% at the first hour ,21 .6% at the second hour ,33 .2%at the third hour and 53 .7% at the twenty‐fourth hour .The cumulative release percentage of clindamycin control was 99 .6% at the third hour .The microspheres still had obvious bacteriostasis after 3 days’ release ,as the bacteriostasis time area curve of the drug loaded microsphere showed .Conclusions:The encapsulation efficiency of clindamycin loaded chitosan sustalned‐release microspheres was good ,so that the sustalned‐release effect and bacteriostsis in vitro was also good .

Objective:To investigate the characteristics and risk factors of local recurrence in resected pancreatic cancer.Methods:The clinicopathological data of 190 patients in whom recurrent sites can be identified after radical resection of pancreatic cancer from Sep 2013 to Aug 2020 at the Cangzhou Central Hospital were retrospectively analyzed. The survival time and clinicopathological characteristics of local recurrence were compared with those of other recurrence types. Cox risk regression model was used to analyze the risk factors of local recurrence.Results:The recurrence sites were local (49 cases, 25.8%), liver (53 cases, 27.9%), lung (35 cases, 18.4%), peritoneal (25 cases, 13.2%) and multiple sites (28 cases, 14.7%). Patients mRFS and mOS were 17.8 months and 30.9 months respectively. The clinicopathological features of patients with local recurrence were compared with those of other recurrence types [tumor diameter ( P=0.023), preoperative CA199 level ( P=0.021), peripancreatic nerve plexus invasion ( P=0.031), lymphovascular invasion ( P=0.004), surgical margin state ( P<0.001) and postoperative adjuvant chemotherapy ( P=0.038)]. Tumor diameter ( P=0.018), peripancreatic nerve plexus invasion ( P=0.002) and postoperative adjuvant chemotherapy ( P=0.004) were independent factors for local recurrence in resected pancreatic cancer, and only peripancreatic nerve plexus invasion was not associated with other recurrence types. Conclusions:Local recurrence in resected pancreatic cancer has important impact on the prognosis of patients. Peripancreatic nerve plexus invasion is an independent factor affecting local recurrence.