Studying clinical feature of 63 patients with some internal diseases who suffered depressive disorder. The occurrence and development of internal diseases were affected by psychological factors, such ad difficuties and conflic tin life. The disorder is more common at age from 20 - 40 (71.42%). Clinical symptoms are variety, including mental and physical disorders. However depressive features are not typical and masked by mental and physical symptoms. In patients with functional disorder, the depression is mild, atypical and it usually combine with anxiety (36.5%), obsession (7.93%), hypochondry (14.28%), cenestopathie (11.11%). Diseases developed chronically with a lot of handicap on health and economy for their family and the community.
Depressive Disorder, Psychology

OBJECTIVE: Pharmacogenomic-based antidepressant treatment (PGATx) may result in more precise pharmacotherapy of major depressive disorder (MDD) with better drug therapy guidance. METHODS: An 8-week, randomized, single-blind clinical trial was conducted to evaluate the effectiveness and tolerability of PGATx in 100 patients with MDD. All recruited patients were randomly allocated either to PGATx (n=52) or treatment as usual (TAU, n=48) groups. The primary endpoint was a change of total score of the Hamilton Depression Rating Scale-17 (HAMD-17) from baseline to end of treatment. Response rate (at least 50% reduction in HAMD-17 score from baseline), remission rate (HAMD-17 score ≥7 at the end of treatment) as well as the change of total score of Frequency, Intensity, and Burden of Side Effects Ratings (FIBSER) from baseline to end of treatment were also investigated. RESULTS: The mean change of HAMD-17 score was significantly different between two groups favoring PGATx by −4.1 point of difference (p=0.010) at the end of treatment. The mean change in the FIBSER score from baseline was significantly different between two treatment groups favoring PGATx by −2.5 point of difference (p=0.028). The response rate (71.7 % vs. 43.6%, p=0.014) were also significantly higher in PGATx than in TAU at the end of treatment, while the remission rate was numerically higher in PGATx than in TAU groups without statistical difference (45.5% vs. 25.6%, p=0.071). The reason for early drop-out associated with adverse events was also numerically higher in TAU (n=9, 50.0%) than in PGATx (n=4, 30.8%). CONCLUSION: The present study clearly demonstrate that PGATx may be a better treatment option in the treatment of MDD in terms of effectiveness and tolerability; however, study shortcomings may limit a generalization. Adequately-powered, well-designed, subsequent studies should be mandatory to prove its practicability and clinical utility for routine practice.
Antidepressive Agents ; Depression ; Depressive Disorder ; Depressive Disorder, Major* ; Drug Therapy ; Generalization (Psychology) ; Humans ; Precision Medicine

BACKGROUND: Although research has established the existence of an association between smoking and depression among adolescents, researchers have not reached consensus on the nature of the association. OBJECTIVES: The purpose of this paper is to review the literature, to examine the nature of the relationship between smoking and depression in adolescence, and to suggest future research directions. METHOD: A literature search was conducted from the following six databases: (a) Ovid MEDLINE, (b) CINAHL, (c) PubMed Unrestricted, (d) PsycINFO, (e) ERIC, and (f) Sociological Abstracts. The combinations of the words, "depression," "smoking," "tobacco," "adolescent," and "teen" were used for keyword searches to find relevant articles. RESULTS: In 47 of 57 studies, significant associations between smoking and depression were found. However, these significant relationships may either be spurious or unrelated to depression because a substantial number of studies did not adjust for confounders or did not use validated instruments to measure depression. Additionally, if the relationship is causal, its direction remains controversial. Five relationships have been suggested: (a) Depression causes smoking, (b) smoking causes depression, (c) there is a bidirectional relationship between smoking and depression, (d) smoking and depression occur due to confounders, and (e) subgroups with different relationships between the two conditions exist. CONCLUSIONS: It is necessary to further explore the relationship between smoking and depression. Future research should consider the need for: (a) longitudinal research designs, (b) more accurate measurement of depression, and (c) the control of confounders between smoking and depression.
Adolescent ; Age of Onset ; Causality ; Depressive Disorder/*epidemiology/psychology ; Disease Progression ; Humans ; Smoking/*epidemiology/psychology

This study aimed at exploring the psychometric characteristics of the Korean Version of the Depression and Somatic Symptoms Scale (DSSS) in a clinical sample, and investigating the impact of somatic symptoms on the severity of depression. Participants were 203 consecutive outpatients with current major depressive disorders (MDD) or lifetime diagnosis of MDD. The DSSS was compared with the Montgomery-Åsberg Depression Rating Scale (MADRS) and the 17-items Hamilton Depression Rating Scale (HAMD). The DSSS showed a two-factor structure that accounted for 56.8% of the variance, as well as excellent internal consistency (Cronbach’s alpha = 0.95), concurrent validity (r = 0.44–0.82), and temporal stability (intraclass correlation coefficient = 0.79). The DSSS had a high ability to identify patients in non-remission (area under receiver operating characteristic [ROC] curve = 0.887). Maximal discrimination between remission and non-full remission was obtained at a cut-off score of 22 (sensitivity = 82.1%, specificity = 81.4%). The number of somatic symptoms (the range of somatic symptoms) and the scores on the somatic subscale (SS, the severity of somatic symptoms) in non-remission patients were greater than those in remission patients. The number of somatic symptoms (slope = 0.148) and the SS score (slope = 0.472) were confirmed as excellent predictors of the depression severity as indicated by the MADRS scores. The findings indicate that the DSSS is a useful tool for simultaneously, rapidly, and accurately measuring depression and somatic symptoms in clinical practice settings and in consultation fields.
Depression* ; Depressive Disorder, Major ; Diagnosis ; Discrimination (Psychology) ; Humans ; Outpatients ; Psychometrics ; ROC Curve ; Sensitivity and Specificity

PURPOSE: This study was designed to examine the relation of trait anger and anger expression to blood pressure, cholesterol, and depression in middle-aged Korean women. METHODS: This descriptive correlational design was conducted using a convenient sample taken from the health center of K University Hospital located in Kyungki province, Korea. The subjects were 252 women aged 40 to 64 years. Spielberger's state trait anger expression inventory - Korean version and Beck's depression inventory were used for measuring trait anger, state anger, anger expression and depression. Data was analyzed by descriptive statistics, t-test, Pearson correlation, two-way ANOVA, and cluster analysis using a pc-SAS program. RESULTS: The anger expression types by cluster analysis were Anger out/in type, Low anger expression type, and Anger control type. The level of cholesterol and depression were significantly higher in women with high anger in and high trait anger. In addition, the level of depression was significantly higher in women with a high anger temperament. CONCLUSIONS: Trait anger and anger in might be related to cholesterol and depression in women. However, this study does not reveal the relation between blood pressure and trait anger and anger expression.
Middle Aged ; Humans ; Female ; *Expressed Emotion ; Depressive Disorder/physiopathology/*psychology ; *Blood Pressure ; Anger/*physiology ; Adult

Onychotillomania, named by Alkiewicz, is a rare psychocutaneous disorder of the nails, and various psychological factors predispose the development of this condition. There has been no report of onychotillomania in Korea. We herein report two cases of onychotillomania seen in the nail clinic of our outpatient department. The first case was a 72 year old woman, who presented with a varying degree of dystrophic change to the first, second and third toenails on her right foot. She had a history of a depressive disorder and hypochondriasis. The second case was a 70 year old woman, who presented with complete destruction of the big toenail on her right foot, plus the 3rd and 4th fingernails of her right hand.
Aged ; Depressive Disorder ; Female ; Foot ; Hand ; Humans ; Hypochondriasis ; Korea ; Nails ; Outpatients ; Psychology

Based on the limitation of biomedical model of tinnitus, more attention has been paid to personalities or psychological aspects. Depressive disorder, anxiety disorder, and sleep disturbance were comorbid illnesses of tinnitus and research showed that neurobiological mechanisms such as dysfunction of limbic system or HPA axis were common in tinnitus and affective disorders and that comorbid psychiatric disorders enhanced the negative outcome of tinnitus. Recently, more attention is being paid to the relation of tinnitus with personality and the role of stress. Although the causal relation of personality and tinnitus is unclear, stress in itself showed that it can be a trigger in the development of tinnitus, and stress of tinnitus can cause adverse effects. Since the effect of fear-related cognition such as catastrophic thought about tinnitus was revealed more recently, its therapeutic implication should be explored. This review will describe the product of previous research and discuss future direction about psychological factors related to tinnitus.
Anxiety Disorders ; Cognition ; Depressive Disorder ; Limbic System ; Mood Disorders ; Psychology* ; Tinnitus*

OBJECTIVETo explore the correlation between depressive disorder and breast cancer, and to study the features of depressive disorder in patients before and after suffering breast cancer.

METHODSWhether 40 breast cancer patients had depressive disorder and their degrees were assessed by filling in Hamilton Depression Rating Scale (HAM-D) at Department of Oncology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences. The correlation between depressive disorder and the occurrence and progression of breast cancer, as well as its features were studied.

RESULTSThe occurrence of general depressive disorder in breast cancer patients before they suffered from breast cancer was 72.5% (29/40 cases). The occurrence of confirmed depression was 2.5% (1/40 cases). The total depressive disorder rate was 75.0% (30/40 cases).They were 60. 0% (24/40 cases), 7.5% (3/40 cases), and 67. 5% (27/40 cases) in breast cancer patients after they suffered from breast cancer.

CONCLUSIONBreast cancer patients have depressive disorder to various levels before and after suffering from breast cancer, which should raise clinical attention and corresponding intervention.

Depressive Disorder, Major ; drug therapy ; psychology ; Humans ; Placebos ; therapeutic use ; Prescriptions ; Treatment Outcome

OBJECTIVE: To investigate the correlation betwen varying degrees of non-acute tinnitus and anxiety and depression. METHOD: Seventy-seven outpatients with non-acute tinnitus as their in chief complaint were submitted to Tinnitus Handicap Inventory(THI), Self-Rating Anxiety Scale(SAS), and Self-Rating Depression Scale (SDS). RESULT: THI and its three subscales were found to have significant correlations with SAS and SDS. The group (THI ≥ 38) had more anxiety and depression than the mild (THI < 38). Significant correlations were also observed between THI, SAS and SDS in the group with THI ≥ 38, in contrast with the group of THI < 38. CONCLUSION Patients with THI ≥ 38 suffered from severe anxiety and depression than the mild. Doctors should pay more attention to these patients, especially their psychological disorders.
Anxiety ; complications ; Depression ; Depressive Disorder ; Humans ; Personality Inventory ; Stress, Psychological ; Surveys and Questionnaires ; Tinnitus ; complications ; psychology