1.Histiocytosis X: A Clinical Study
Nam Hyun KIM ; Deok Soon OH ; Byoung Soo KIM
The Journal of the Korean Orthopaedic Association 1982;17(1):60-68
Letterer-Siwe disease, Hand-Schuller-Christian disease and eosinophilic granuloma of the bone are merely different clinical expressions of one disease. Lichtenstein grouped these three clinical syndromes and proposed that this disease be termed histiocytosis X. This grouping was based on the histologic similarities and the possibility of transformation of one syndrome into another. The cause of histiocytosis X remains unknown. Histiocytosis X is a condition that presents single or multiple lesions, distributed in the soft tissue, lymph nodes, various organ and bones, especially in the areas of marked reticuloendothelial activity. The authors reviewed the clinical findings, radiographs and the treatment of the twenty-six patients with histiocytosis X diagnosed on the base of pathologic findings at Severance Hospital, between January, 1971 and December, 1980. Among the twenty-six patients, twenty-one patients could be followed, ranging from one month to six years, with an average follow-up of 1.6 years. The results obtained were as follows: 1. There was a slight male predominance (61.6%). The age ranged from 2 months to 42 years (average 8.2 years). Sixty-five percents of patients were the child under 4 years of age. 2. Hand-Schuller-Christian disease (50%) was the most common form of this disease. Letterer-Siwe disease developed in the youngest (average 1.2 years) and eosinophilic granuloma in the eldest (average 20.4 years). 3. The common manifestations were hepatomegaly, skin rashes and anemia in Letterer-Siwe disease; palpable mass, pain and exophthalmos in Hand-Schuller-Christian disease; pain and mass in eosinophilic granuloma. 4. The common sites of the skeletal lesions were skull, spine and femur, etc. 5. The patients with single skeletal lesion improved regardless of the methods of treatment. 6. Vinblastine, methotrexate and/or prednisone were valuable agents for the multiply involved patients. 7. Prognosis was poor for the patients who were young at onest, or who had multiple systemic involvements, but in case only with skeletal involvement the prognosis was good. Eosinophilic granuloma is the most benign variant, while Letterer-Siwe disease is the most malignant type.
Anemia
;
Child
;
Clinical Study
;
Eosinophilic Granuloma
;
Exanthema
;
Exophthalmos
;
Femur
;
Follow-Up Studies
;
Hepatomegaly
;
Histiocytosis
;
Histiocytosis, Langerhans-Cell
;
Humans
;
Lymph Nodes
;
Male
;
Methotrexate
;
Prednisone
;
Prognosis
;
Skull
;
Spine
;
Vinblastine
2.A Clinical Study on the Fractures of the Calcaneus
Byeong Mun PARK ; Nam Hyun KIM ; Dae Young HAN ; Deok Soon OH
The Journal of the Korean Orthopaedic Association 1982;17(4):697-703
The os calcis is fractured more frequently than any other tarsal bone. Fractures involving subtalar joint can, be associated with prolonged and severe disability. So there is no universal agreement in the treatment of these fractures. Calcaneal fractures of 64 feet in 56 patients who were treated at Severance Hospital, Yonsei University College of Medicine from Jan. 1971 to Dec. 1980 were analyzed in clinical and radiological aspects. The results obtained from this study were as follows; 1. Of 56 patients, 46 patients were male and 10 female. 2. The main cause of fractures of calcaneus was a fall from a height in 71.4 percents of cases, and spine injury was associated in 15 patients (26.8%) with calcaneal fractures. 3. The fractures were almostly closed (89.1%). 4. Fractures involving subtalar joint were in 52 feet (81.3%) and Rowe's type 5 were 38 fractures (39.4%). Of these type 5 fractures, 31 fractures were treated by closed reduction and axial pin fixation and then favourable results were obtained. 5. The most common complication after treatment was persistant foot pain. Pain beneath the lateral malleolus was the most common (8 feet), and correlated with the decrease of Bohler's angle.
Calcaneus
;
Clinical Study
;
Female
;
Foot
;
Humans
;
Male
;
Spine
;
Subtalar Joint
;
Tarsal Bones
3.Scintigraphic Analysis of Left Ventricular Diastolic Function in Coronary Artery Disease.
Eun Seok JEON ; Deok Kyung KIM ; Byung Hee OH ; June Key CHUNG ; Myoung Mook LEE ; Young Bae PARK ; Jung Don SEO ; Young Woo LEE ; Chang Soon KOH
Korean Circulation Journal 1987;17(2):289-298
To evaluate left ventricular diastolic function in patients with coronary artery disease, gate radionuclide ventriculography was performed prospectively in 42 patients who were admitted to Seoul National University Hospital from November 1985 to August 1986 because of anterior chest pain. All patients had no valvular heart disease, congenital heart disease, cardiomyopathy and arrhythmia, and no abnormal vall motion in gated nuclide ventriculography and contrast left ventriculography. 25 patients with more than 50% of stenosis in coronary arteriography were compared with 17 control subjects without stenosis. The following results were obtained; 1) There were no significant differences between normal controls and patients with coronary artery disease in the analysis of the parameters of the left ventricular systolic function, such as ejection fraction (EF), peak ejection rate (PER), time to peak ejection rate (TPER) and ejection time (TES, TES/BCL). 2) Same results were found with those of the left vnetricular diastolic function, such as peak filling rate (PFR), diastolic time interval (DTI, DTI/BCL), rapid diastolic filling interval and time to late diastolic filling (TLDF). 3) The percent contribution of late diastolic filling to stroke volume (%LDF/SV) was more increased in patients with coronary artery disease than the normal control subjects (38.2+/-12.4% vs 28.3+/-7.8%, P<0.01). 4) As the results of above, it can be concluded that the percent contribution of late diastolic filling to stroke volume (%LDF/SV) obtained by using the non-invasive method of gated radionuclide ventriculography can be a sensitive parameter for early evaluation of the left ventricular diastolic dysfunction in coronary artery disease.
Angiography
;
Arrhythmias, Cardiac
;
Cardiomyopathies
;
Chest Pain
;
Constriction, Pathologic
;
Coronary Artery Disease*
;
Coronary Vessels*
;
Gated Blood-Pool Imaging
;
Heart Defects, Congenital
;
Heart Valve Diseases
;
Humans
;
Prospective Studies
;
Radionuclide Ventriculography
;
Seoul
;
Stroke Volume
4.A Clinical Study on Respiratory Intensive Cares in Critically Ill Patients (The Third Report).
Kwang Woo KIM ; Seong Deok KIM ; Yong Seok OH ; Dae Soon CHO
Korean Journal of Anesthesiology 1981;14(1):64-71
A clinical study was analyzed on respiratory care of 919 critically ill patients who admitted between 1976 and 1979, which was 4.3% of 16,617 patients in post-operative recovery room of Seoul National University Hospital. 1) The patients who need respiratory cares were annually increased 76 in 1979, 115 in 1977, 289 in 1978 and 439 in 1979, and their overall mortality was 16.8%. 2) Among 439 patients, male were 267(60.8%), and female 172(39.2%) in 1979. 3) The highest age group was 1 to 10 year of age, 142 patients in number(32.4%). 4) The duration of ventilatory assistance was the longest(144.02 hours) for patients of abdominal surgery and 17.5 hours for patients of open heart surgery. 5) Major causes of deaths(84cases) in respiratory care patients of respiratory intensive care units were brain injuries(29 cases) and low cardiac output syndromes(28cases). 6) Types of airway in ventilatory assistance were orotracheal routes(345 cases) and tracheostomy routes(81 cases). 7) Importances of hemodynamic monitorings including Swan-Ganz catheterizations and blood gases and measurements of colloid osmotic pressure for critically ill patients in respiratory care units were literarily discussed.
Brain
;
Cardiac Output, Low
;
Catheterization
;
Catheters
;
Clinical Study*
;
Colloids
;
Critical Illness*
;
Female
;
Gases
;
Hemodynamics
;
Humans
;
Intensive Care Units
;
Male
;
Mortality
;
Osmotic Pressure
;
Recovery Room
;
Respiratory Care Units
;
Seoul
;
Thoracic Surgery
;
Tracheostomy
5.First Report of Nocardia farcinica Bursitis in a Patient with Diabetes Mellitus.
Soon Deok PARK ; Han Jun KIM ; In Ho JANG ; Young UH ; Juwon KIM ; Kap Joon YOON ; Jin Rok OH
Annals of Laboratory Medicine 2014;34(3):252-255
No abstract available.
Aged
;
Anti-Bacterial Agents/therapeutic use
;
Bursitis/*diagnosis/drug therapy/microbiology
;
Cefoperazone/therapeutic use
;
Diabetes Mellitus, Type 2/complications/*diagnosis
;
Humans
;
Male
;
Nocardia/genetics/*isolation & purification
;
Polymerase Chain Reaction
;
RNA, Ribosomal, 16S/chemistry/genetics
;
Sequence Analysis, RNA
;
Sulbactam/therapeutic use
6.Stenosis of the Colon Due to Chronic Pancreatitis Mimicking Colon Cancer.
Young Deok CHO ; Su Jin HONG ; Jong Ho MOON ; Jin Oh KIM ; Joo Young CHO ; Joon Seong LEE ; Moon Sung LEE ; Chan Sup SHIM
Korean Journal of Gastrointestinal Endoscopy 1998;18(4):605-610
Obstruction of the gastrointestinal tract by the progressive fibrotie process of chronic pancreatitis is being recognized with increasing frequency. The structures commonly affected are parapancreatic in location and include the common bile duct in its intrapancreatic portion, the second and third portion of the duodenum and the colon, most commonly the transverse segment. Colonic involvement of varying severity is less common and not well recongnized, and stenosing lesions of the colon are a rare and confusing sequale to pancreatitis. Some cases of colonic stenosis complicated by pancreatitis cannot be differentiated radiologically from carcinoma. The clinical history, enzyme studies and location of the stenosis in the left colon may alert the clinician to this rare diagnosis. We report a patient with stenosis of the colon due to chronic pancreatitis in whom the initial presenting symptoms and radiologic finding resemble colon cancer.
Colon*
;
Colonic Neoplasms*
;
Common Bile Duct
;
Constriction, Pathologic*
;
Diagnosis
;
Duodenum
;
Gastrointestinal Tract
;
Humans
;
Pancreatitis
;
Pancreatitis, Chronic*
7.Macrolide Resistance of Mycoplasma pneumoniae and Its Detection Rate by Real-Time PCR in Primary and Tertiary Care Hospitals.
Young UH ; Joo Hee HONG ; Ki Jin OH ; Hyun Mi CHO ; Soon Deok PARK ; Juwon KIM ; Kap Jun YOON
Annals of Laboratory Medicine 2013;33(6):410-414
BACKGROUND: This study aimed to evaluate the prevalence of Mycoplasma pneumoniae in primary and tertiary care hospitals and its macrolide resistance rate. METHODS: Nasopharyngeal swabs were collected from 195 pediatric patients in primary and tertiary care hospitals from October to November 2010. The AccuPower MP real-time PCR kit (Bioneer, Korea) was used for the detection of M. pneumoniae. Direct amplicon sequencing was performed to detect point mutations conferring resistance to macrolides in the 23S rRNA gene. RESULTS: Among the 195 specimens, 17 (8.7%) were M. pneumoniae positive, and 3 of the strains (17.6%) obtained from these 17 specimens displayed the A2063G mutation in 23S rRNA. Three macrolide-resistant M. pneumoniae isolates were isolated from patients hospitalized at the primary care hospital. The positive rates of M. pneumoniae for the primary and tertiary care hospitals were 12.1% (15/124) and 2.8% (2/71), respectively (P=0.033). CONCLUSIONS: The positive rate of M. pneumoniae in the primary care hospital was higher than that in the tertiary care hospital. Simultaneous detection of M. pneumoniae and macrolide-resistant mutation genes in the 23S rRNA by real-time PCR is needed for rapid diagnosis and therapy of M. pneumoniae infections.
Anti-Bacterial Agents/*pharmacology
;
Child, Preschool
;
Drug Resistance, Bacterial/*drug effects
;
Female
;
Humans
;
Infant
;
Infant, Newborn
;
Macrolides/*pharmacology
;
Male
;
Mycoplasma pneumoniae/genetics/*isolation & purification
;
Nasopharynx/microbiology
;
Pneumonia, Mycoplasma/epidemiology/microbiology
;
Primary Health Care
;
RNA, Ribosomal, 23S/analysis
;
Reagent Kits, Diagnostic
;
Real-Time Polymerase Chain Reaction
;
Tertiary Healthcare
8.Endoscopic Photodynamic Diagnosis (PDD) Using Oral 5-aminolevulinic Acid in Gastrointestinal Cancer and Dysplastic Lesions.
Young Koog CHEON ; Young Deok CHO ; Jin Oh KIM ; Joo Yong CHO ; Joon Seong LEE ; Yun Soo KIM ; Moon Sung LEE ; Chan Sup SHIM
Korean Journal of Gastrointestinal Endoscopy 2003;26(2):73-78
BACKGROUND/AIM: Endoscopic screening for the detection of premalignant high-grade dysplasia remains time consuming and is subject to sampling error. We performed this study to determine the clinical usefulness of laser endoscopic spectra analyzer (LESA-7) in gastrointestinal cancer and dysplastic lesions. METHODS: Seventeen patients with histologically proven carcinoma or adenoma with or without high-grade dysplasia were treated with oral administration of 5-ALA (20 mg/kg). PDD was performed 4 hours later. The fluorescence was excited by a helium-neon laser with emission at 637 nm. The generated fluorescence light was collected and fed into a multi-channel analyzer and the full spectrum was displayed in real time (LESA-7). RESULTS: In most of malignant tumors, a clear protoporphyrin IX-related dual-peaked fluorescence signal at about 635 and 700 nm was identified in the fluorescence spectra. However, it was not fully identified in bile duct cancers. In PDD of post-EMR in order to detect residual lesions (gastric flat adenoma 1, early gastric cancer 2), a dual spectra was not identified. CONCLUSIONS: PDD with 5-ALA might be useful for the detection of dysplasia and carcinoma in the gastrointestinal tract.
Adenoma
;
Administration, Oral
;
Bile Duct Neoplasms
;
Diagnosis*
;
Fluorescence
;
Gastrointestinal Neoplasms*
;
Gastrointestinal Tract
;
Humans
;
Mass Screening
;
Selection Bias
;
Stomach Neoplasms
9.A Comparative Study for Usefulness of a Variable-Stiffness Colonoscope to a Conventional Colonoscope.
Young Koog CHEON ; In Sup JUNG ; Young Deok CHO ; Jin Oh KIM ; Moon Sung LEE ; Chan Sup SHIM
Korean Journal of Gastrointestinal Endoscopy 2002;25(3):132-136
BACKGROUND/AIMS: Loop formation during colonoscopy can adversely effect on completion rates, speed of intubation and patient tolerance of the procedure. The ability to vary endoscope shaft flexibility may help insertion to the cecum. The aim was to compare a variable colonoscope with adjustable shaft stiffness to a conventional colonoscope (CC). METHODS: Consecutive patients attending for day case colonoscopy were randomized for examination with either the conventional colonoscope (Olympus CF200Z) or a variable stiffness (VS) colonoscope (CFQ240AL). The time to the cecum, inserted length of scope at cecum, need for abdominal compression, need for rotation of body position and pain scores of patient were analyzed. RESULTS: Of 158 cases, 69 were performed with the CC, and 89 with VS. There was no difference in intubation time between VS (mean 5.15+/-2.61 min) and CC (6.01+/-3.31 min) in experienced group. However, intubation time was quicker with VS than with CC (VS: 8.48+/-5.59, CC: 11.58+/-4.70, p=0.039) and number of loop formation was less with VS (mean 1.20) than with CC (mean 1.84) (p=0.043) in trainee group. There were no significant differences in inserted length of scope at cecum, need for abdominal compression, pain score or need for patient rotation between VS and CC in two groups. CONCLUSIONS: There was no significant difference in cecal intubation time between two groups in experienced group. However, in trainee group, the intubation time was quicker and the number of loop formation were lower in VS group than CC group.
Cecum
;
Colonoscopes*
;
Colonoscopy
;
Endoscopes
;
Humans
;
Intubation
;
Pliability
10.A Case of Acute Recurrent Pancreatitis Caused by Branch Duct Type IPMN and Ampulla of Vater Adenoma with High Grade Dysplasia.
Chang Kyo OH ; Ki Deok YOO ; Ho Soon CHOI ; Kang Nyeong LEE ; Gun Woo KOO ; Seung LEE ; Ki Seok JANG
Korean Journal of Medicine 2014;87(5):579-584
Acute pancreatitis is an inflammatory disease that can extend to extra-pancreatic tissues and distant organs. Detecting the underlying cause is important because it helps provide an appropriate treatment plan and improve prognosis. An underlying cause cannot be identified after initial evaluation in 10-30% of patients with acute pancreatitis, and they are diagnosed with idiopathic acute pancreatitis. Here, we report a case of a 77-year-old woman with acute recurrent pancreatitis caused by a branch duct-type intraductal papillary mucinous neoplasm (IPMN) and an ampulla of Vater adenoma. Abdominal computed tomography and magnetic resonance cholangiopancreatography revealed only IPMN. However, endoscopic retrograde cholangiopancreatography revealed a mucosal abnormality of the ampulla of Vater. The mucosal abnormality was documented to be an ampulla of Vater adenoma with high-grade dysplasia.
Adenoma*
;
Aged
;
Ampulla of Vater*
;
Cholangiopancreatography, Endoscopic Retrograde
;
Cholangiopancreatography, Magnetic Resonance
;
Female
;
Humans
;
Mucins
;
Pancreatitis*
;
Prognosis