Clear-cell chondrosarcoma, a recently specified entity, is a low-grade malignant tumor and has characteristic clinical, roentgenographic and pathologic findings which separate it from conventional chondrosarcoma and other benign tumors. Therefore, correct diagnosis is important from the viewpoint of both prognosis and therapeutic approach. We report a case of typical recurrent clear-cell chordirosarcoma. Typical round cells with clear cytoplasm, large nuclei, and small nucleoli were wellnoted. The clear cytoplasm was faintly positive in PAS staining. Electronmicroscopic study showed that these cells were of chondroid origin, showing indented nuclei, large dilated endoplasmic reticulum cisternae, bundles of actin-like filaments and a few glycogen particles.
Chondrosarcoma/*pathology/ultrastructure ; Female ; Femoral Neoplasms/*pathology/ultrastructure ; Humans ; Microscopy, Electron ; Middle Aged ; Neoplasm Recurrence, Local/*pathology/ultrastructure

Intracranial complications of sinusitis are known as serious illness, however, they are often neglected because their initial symptoms are not definitively remarkable. Although the incidence is progressively decreasing since the development of antibiotics, these intracranial complications are still very dangerous to death until now. Brain abscess, along with meningitis, is regarded as one of the most common intracranial complication of sinusitis. Brain abscess of sinus origin develops most commonly in the frontal lobe and usually secondary to infection in the frontal or ethmoid sinus either as isolated infection or part of pansinusitis. Both craniotomy and sinus surgery as well as administration of massive intravenous antibiotics are necessary for complete eradication of sinogenic brain abscess. However, little information has been available on the appropriate management of sinogenic multiple brain abscesses. We have experienced a case of multiple brain abscesses secondary to acute pansinusitis in 17 year-old female patient. So we report a case of sinogenic multiple brain abscesses treated by craniotomy and endoscopic sinus surgery with massive intravenous antibiotics.
Adolescent ; Anti-Bacterial Agents ; Brain Abscess* ; Craniotomy ; Ethmoid Sinus ; Female ; Frontal Lobe ; Humans ; Incidence ; Meningitis ; Sinusitis

BACKGROUND AND OBJECTIVES: The influence of anterior inferior cerebellar artery (AICA) loop on sudden sensorineural hearing loss (SSHL) remains controversial. The objective of this study was to evaluate the correlation between the anatomical type of AICA loop and SSHL. SUBJECTS AND METHOD: We reviewed the medical records of 69 ears from 60 patients with SSHL between January 2005 and April 2008, retrospectively. AICA loops were classified according to the Chavda classification method by magnetic resonance imaging. According to the extension depth of the loop in the internal auditory canal, it was classified as type I, II and III. The loop was classified as S (small diameter) and L (large diameter) by comparing the thickness of the loop with adjacent facial nerves. RESULTS: The predominant type of AICA loop was type I (68.1%) and type S (78.3%). There was no significant correlation between the pretreatment hearing level, extension depth and diameter. There was also no significant correlation between the rate of hearing recovery by Siegel's criteria and diameter. However, there was significant correlation between the rate of hearing recovery by Siegel's criteria and the types of the extension depth (p< 0.05). The ears with type II and III of AICA loop presented higher rates of hearing recovery by Siegel's criteria than those with type I. CONCLUSION: This study suggests that the type II and III of AICA loop may be considered a good prognostic factor in SSHL.
Arteries ; Ear ; Facial Nerve ; Hearing ; Hearing Loss, Sensorineural ; Humans ; Magnetic Resonance Imaging ; Medical Records ; Retrospective Studies

BACKGROUND AND OBJECTIVES:Extranasal approach has been emphasized treatment of choice in inverted papilloma of nasal cavity and paranasal sinuses until several years ago. However, nowadays conservative transnasal endoscopic surgery is done in properly selected cases of inverted papilloma. The aim of this study was to compare the long-term outcomes of transnasal endoscopic and extranasal surgical management of inverted papilloma. MATERIALS AND METHODS: Among 33 patients who were pathologically diagnosed as inverted papilloma from January 1990 to August 1997, we reviewed the medical records and CT scans of 25 patients who underwent surgical treatment and were available for the follow up at least more than 2 years, retrospectively. RESULTS: Thirteen patients were treated via transnasal endoscopic approach and twelve patients by extranasal approach. According to Skolnik(1966)'s stage classification, 20 patients showed stage T3. Eleven patients of them were treated via transnasal endoscopically and 9 patients extranasally. Four minor postoperative complications, such as epiphora, septal perforation, vestibular pain and facial parasthesia, were noted in extranasal approach group. One case(7.7%) recurred in conservative transnasal endoscopic surgery group during mean 38 months follow up period. However, no recurrence was found in extranasal approach group during mean 60 months follow up period. CONCLUSION: If endoscopic surgery is performed by experienced surgeons in adequately selected patients, conservative transnasal endoscopic surgery can be considered as an alternative surgical modality in inverted papilloma of nasal cavity and paranasal sinuses.
Classification ; Follow-Up Studies ; Humans ; Lacrimal Apparatus Diseases ; Medical Records ; Nasal Cavity* ; Papilloma, Inverted* ; Paranasal Sinuses* ; Postoperative Complications ; Recurrence ; Retrospective Studies ; Tomography, X-Ray Computed

Bronchioloalveolar carcinoma is originated from the periphery of the lung and can be mistaken for lobar pneumonia or atypical pneumonia clinically and at gross examination. Recently the authors experienced a 67-year-old woman who had slowly progressed pulmonary lesions for four years. At first, she visited this hospital for intermittent chest pain four years before. And she visited other hospitals for the same problem and had a series of evaluation including two times of biopsy but did not have any conclusive diagnosis. With aggravation of chest pain, she was referred to this hospital again and the lesion was reexamined and confirmed as bronchioloalveolar carcinoma by ultrasonography-guided needle biopsy. Being performed left lower lobectomy, she kept good condition without any complication.
Adenocarcinoma, Bronchiolo-Alveolar ; Aged ; Biopsy ; Biopsy, Needle ; Chest Pain ; Diagnosis ; Female ; Humans ; Lung ; Pneumonia

PURPOSE: Calcium ionophore (CI) is used to generate dendritic cells (DCs) from progenitor cells, monocytes, or leukemic cells. The aim of this study was to determine the optimal dose of CI and the appropriate length of cell culture required for acute myeloid leukemia (AML) cells and to evaluate the limitations associated with CI. MATERIALS AND METHODS: To generate leukemic DCs, leukemic cells (4 x 10(6) cells) from six AML patients were cultured with various concentrations of CI and/or IL-4 for 1, 2 or 3 days. RESULTS: Potent leukemic DCs were successfully generated from all AML patients, with an average number of 1.2 x 10(6) cells produced in the presence of CI (270 ng/ml) for 2 days. Several surface molecules were clearly upregulated in AML cells supplemented with CI and IL-4, but not CD11c. Leukemic DCs cultured with CI had a higher allogeneic T cell stimulatory capacity than untreated AML cells, but the addition of IL-4 did not augment the MLR activity of these cells. AML cells cultured with CI in the presence or absence of IL-4 showed increased levels of apoptosis in comparison to primary cultures of AML cells. CONCLUSION: Although CI appears to be advantageous in terms of time and cost effectiveness, the results of the present study suggest that the marked induction of apoptosis by CI limits its application to the generation of DCs from AML cells.
Apoptosis ; Calcium* ; Cell Culture Techniques ; Cost-Benefit Analysis ; Dendritic Cells ; Humans ; Interleukin-4 ; Leukemia, Myeloid, Acute ; Monocytes ; Stem Cells