Objective To explore the optimum chest compression frequency and influencing factors of compression quality so as to provide reference and guidance for guaranteeing the high quality of CPR and related training.Methods A total of 1 75 new nurses attended a training on theory and skills of CPR for 3 days.And then,they were divided into 5 groups (1 control group +4 experimental groups)by random number method. Nurses in control group performed chest compression for 2 minutes without guidance for the frequency.In contrast,nurses in 4 experimental groups performed chest compression with the frequency of 1 00,1 1 0,1 20, 1 40 beats per minute (BPM)for 2 minutes guided by metronome.Results Compression quality indicators of 3 experimental groups (1 00,1 1 0,1 20 BPM)were better than that of control and 1 experimental groups (1 40 BPM).Compression frequency and weight of chest compression providers could collectively explain 1 3%, 1 0%,1 1 %,1 1 % of the variation in average compression depth,percentage of compression with sufficient depth,the ratio of time on compression and recoil,time to fatigue.Conclusions The optimum frequency is 1 00 -1 20 BPM.Compression frequency and weight of chest compression provider are influencing factors of compression quality.